Synthesis and Characterization of Derivatives of the Antifungal Peptoid RMG8-8.

Cryptococcal meningitis, caused by the fungal pathogen Cryptococcus neoformans, is a devastating disease with a mortality rate of over 80%. Due to the increasing prevalence of resistance to antifungals and the high mammalian toxicity of current treatments, the development of new antifungal therapies is vital. In an effort to improve the biological properties of a previously discovered antifungal peptoid, termed RMG8-8, an iterative structure-activity relationship study was conducted. This three-round study sought to optimize the structure of RMG8-8 by focusing on three main structural components: the lipophilic tail, aliphatic side chains, and aromatic side chains. In addition to antifungal testing against C. neoformans, cytotoxicity testing was also performed on all derivatives against human liver cells, and select promising compounds were tested for hemolytic activity against human red blood cells. A number of derivatives containing unique aliphatic or aromatic side chains had antifungal activity similar to RMG8-8 (MIC = 1.56 µg/mL), but all of these compounds were more toxic than RMG8-8. While no derivative was improved across all biological tests, modest improvements were made to the hemolytic activity with compound 9, containing isobutyl side chains in positions 2 and 5, compared to RMG8-8 (HC10 = 130 and 75 µg/mL, respectively). While this study did not yield a dramatically optimized RMG8-8 derivative, this result was not totally unexpected given the remarkable selectivity of this compound from discovery. Nonetheless, this study is an important step in the development of RMG8-8 as a viable antifungal therapeutic.

Recycled water acceptance: Data from two Spanish regions with opposite levels of scarcity.

The dataset presented in this paper were collected for testing a perceptive-axiological model of recycled water acceptance for low and high contact uses. Participants were selected by proportional random sampling by sex and age the two Spanish communities with the most extreme values of water stress (Galicia, the rainiest region and Murcia, the driest). Data were collected by a company specialized in market research using an online survey housed on Qualtrics. Participants who matched the specified profile were contacted by email. The company compensated them financially. The final sample size consisted of 726 valid responses. The survey collected data on a variety of variables related to three conceptual dimensions: the diagnosis of the environmental situation, the axiological influence and the public perceptions regarding recycled water. The survey also collected demographic data from respondents. The survey was designed and reviewed by four experts in social psychology and two experts in methodology. The dataset featured in this article provides the raw survey data plus sociodemographic distribution, survey items, and other statistical data. This is the first and most comprehensive set of comparative data known to the authors on public acceptance of water reuse for high and low contact uses comparing regions with and without water scarcity. The authors have published an open access paper based on this data set, which are linked to this paper. Water industry professionals, policymakers, researchers and other stakeholders aiming to implement wastewater reuse systems in society may be interested in using the data as a point of comparison for their own study on public acceptance of water reuse or examining the data for relationships not yet explored in the literature.

From scarcity problem diagnosis to recycled water acceptance: A perceptive-axiological model (PAM) of low and high contact uses.

Water scarcity is a major problem that affects a greater number of countries every year. A possible solution is using recycled water systems. However, to implement the use of recycled water, public acceptance is needed. In this study, we propose a perceptive-axiological model (PAM) to understand the reasons for public acceptance or rejection of recycled water. This is the first model to jointly consider three conceptual dimensions: the diagnosis of the environmental situation, the axiological influence and the public perceptions regarding recycled water. The sample in this study consisted of 726 randomly selected participants who completed an online questionnaire. A key factor considered was the type of water use (low- or high-contact). Additionally, the model's ability to predict acceptance in regions of high and low water stress was tested. The model showed good fit and predictive capacity for both low (R2 = .272) and high (R2 = .501) contact uses and partial equivalence between regions. Threat perception was the most distal variable in the model which, together with identity, affected the attribution of responsibility. These variables, along with trust in scientists, affected the three direct predictors of acceptance: perceived health risks, moral obligation, and cost-benefit analysis. Perceived health risk was the most important predictor in both types of contact (ß = -.642 in high-contact, ß = -.388 in low-contact uses). Moral obligation had a greater impact in high-contact (ß = .170) than in low-contact (ß = .099) uses; the opposite outcome occurred with respect to costs-benefit analysis (ß = .067 in high-contact, ß = .219 in low-contact uses). The PAM offers a general framework that identifies the importance of the three dimensions and how they interact with each other, which facilitates the development of strategies to increase acceptance. On the one hand, the PAM works as a tool to assess the profile of a specific population and, on the other hand, it highlights the specific factors which are the best suited for interventions to increase public acceptance.

Multidimensional Model of Environmental Attitudes: Evidence Supporting an Abbreviated Measure in Spanish.

We conducted three independent studies to support the Spanish version of the Environmental Attitudes Inventory (EAI). The first study consisted of translating and pre-testing on a sample of 125 college students. The second consisted of testing the EAI on a sample of 225 university students in several undergraduate courses. Student data were collected using two different methods, through an online teaching platform and in the classroom. The findings were symmetrical in terms of precision and dimensionality. The third study completed the aforementioned ones testing the items on a representative sample from the general population in Spain. The participants were 630 citizens from 17 regions and responded to the EAI using an online platform. The results of the factor analysis led us to propose a measurement model, with 18 items and six first-order factors: environmental movement activism, conservation motivated by anthropocentric concern, confidence in science and technology, personal conservation behaviour, human dominance over nature, and support for population growth policies. External validity evidence was assessed by the correlation with the following variables: neuroticism, ecological behaviour, limits to economic growth, economic liberalism, sustainability, altruism, and social desirability. These estimations stayed away from demographic and personal aspects such as age, sex, political ideology, and region.

Psychological and Situational Variables Associated with Objective Knowledge on Water-Related Issues in a Northern Spanish City.

This study brings together the level of objective knowledge on water-related issues and other variables of psychological and situational nature. A random sample of 459 participants was employed, selected proportionally based on sex and age. In this sample, knowledge on the water-related issues tended to be low, particularly related to the direct source of water in the household, the type of services involved in the management, and consumption itself. In order to understand both the relationship with knowledge on water and the relative importance of all the other factors, a regression model was formulated. The highest standardised effect was for sex, followed by occupation, political leaning, and water-related emotions. The best level of knowledge was attained if the residents were male, if they were actively employed or unemployed, if their political leaning was towards the left, and if they demonstrated greater emotional involvement with the water use. Consequently, the design of programmes would need to consider that the information flow must be greater for citizens as a whole, particularly for certain groups such as women and students. It should contribute to the realistic perception of water as a problem and to seek emotional involvement.

Broad cognitive complaints but subtle objective working memory impairment in fibromyalgia patients.

BACKGROUND: Cognitive dysfunction in fibromyalgia (FM) encompasses objective cognitive difficulties, as measured in neuropsychological tests, and self-reported cognitive complaints. Although it has been suggested that FM patients display problems in working memory, the data are inconsistent, and the overall working memory status of the patients is unclear. It is also not clear whether the working memory problems are related to cognitive complaints or how the dyscognition is affected by the characteristic clinical symptoms of FM. METHODS: To clarify these aspects, we explored the neuropsychological performance for different components of working memory and the subjective self-perception of cognitive status in a sample of 38 women with FM. They were compared with a matched group of 32 healthy women. RESULTS: Our findings suggested that the FM patients do not differ from healthy controls in their overall working memory functioning. Only a poor performance was found in a single task of visuospatial working memory, mediated by the presence of depressive symptoms, fatigue and pain. The FM patients also displayed a higher level of perception of cognitive difficulties than healthy controls, and this difference was mediated by depression and fatigue. Furthermore, cognitive complaints in FM patients were only associated with a lower verbal WM capacity. DISCUSSION: FM patients have a subtle specific impairment in their working memory functioning, as well as elevated concern about their cognitive status. These findings suggest a disconnection between neuropsychological performance and subjective complaints. In FM patients, clinical variables such as pain, fatigue, and depression play an important role in dyscognition, as assessed by both objective and subjective measures, and should be taken into account in future research.

Factor structure of mood over time frames and circumstances of measurement: Two studies on the Profile of Mood States questionnaire.

This paper presents the results of two studies on the invariance of the Profile of Mood States questionnaire across response time frames and circumstances of administration. We applied Spanish versions of the instrument to gather data from 1146 athletes. In the first study (N = 700), we tested the factor structure of the questionnaire in training sessions by using two different time frames: 'right now' (n = 350) and 'past week' (n = 350). In the second study (N = 446), we compared the factor structure of the questionnaire with data collected using the instruction 'right now' at two different circumstances: 'training' (n = 223) and 'competition' (n = 223). Data analysis was similar in both studies. We conducted multi-group confirmatory factor analyses and applied the scaled difference chi-square statistic to examine whether discrepancies in successive constrained models were significant. We observed configural equivalence between the two time frames. Furthermore, we observed metric equivalence but not scalar invariance between the different circumstances of measurement. The findings highlight the need for studies of equivalence before using a single self-report with more than one set of instructions, or under diverse circumstances. Invariance of mood scores should be examined and taken into account when interpreting individual and group mood state assessments.

Persistencia con estatinas en prevención primaria de enfermedad cardiovascular: resultados en una cohorte de trabajadores españoles / Persistence with statins in primary prevention of cardiovascular disease: findings from a cohort of spanish workers

Introducción y objetivos: El objetivo de este estudio es analizar el patrón de persistencia con estatinas en prevención primaria de enfermedad cardiovascular en una cohorte de trabajadores españoles. Métodos: Este estudio descriptivo se llevó a cabo en el marco del estudio prospectivo longitudinal Aragon Workers'Health Study (n = 5.400). Se identificó a los nuevos usuarios de estatinas varones a partir de datos recogidos en el sistema de información de consumo farmacéutico de Aragón. Se analizaron los patrones de persistencia con estatinas prescritas en prevención primaria cardiovascular, así como los potenciales predictores. Resultados: De los 725 nuevos usuarios de estatinas, menos de un tercio habían persistido durante el año de seguimiento. Alrededor de un 15% de los usuarios no persistentes interrumpieron la terapia con estatinas tras la dispensación de la primera receta y, el 42,1% de ellos no reiniciaron el tratamiento durante el resto del año. La mayor edad (HR = 0,55; IC95%, 0,39-0,77) y el cotratamiento con fármacos antihipertensivos (HR = 0,68; IC95%, 0,56-0,82) redujeron la probabilidad de que se interrumpiera el tratamiento. No se observó asociación entre la persistencia con el tratamiento y la toma concomitante de fármacos antidiabéticos o antitrombóticos, las concentraciones basales de lipoproteínas de baja densidad o las de colesterol total. Sin embargo, la persistencia sí estuvo influida por el tipo de la primera estatina prescrita. Conclusiones: Nuestro análisis en una cohorte de trabajadores varones sanos muestra una baja persistencia con estatinas. Estos resultados reflejan la necesidad de comprender mejor los patrones de utilización de estatinas, especialmente por individuos aparentemente sanos, y de incorporar la conducta del paciente a las decisiones de prescripción (AU)

Introduction and objectives: The aim of this study was to assess patterns of treatment persistence in a cohort of male Spanish workers receiving statin therapy for primary prevention of cardiovascular disease. Methods: This descriptive study was conducted within the framework of the prospective longitudinal Aragon Workers'Health Study (N = 5400). Incident male statin users were identified based on data collected from the regional government's medication consumption information system. Patterns of treatment persistence with statins prescribed for primary cardiovascular disease prevention were assessed and the relevance of potential predictors explored. Results: Among the 725 new statin users, less than one third remained persistent during the 1 year of follow-up. About 15% of nonpersistent users discontinued statin therapy after dispensation of the first prescription; of these, 42.1% did not recommence treatment within the following year. Factors reducing the likelihood of treatment discontinuation were older age (HR, 0.55; 95%CI, 0.39-0.77) and cotreatment with antihypertensive drugs (HR, 0.68; 95%CI, 0.56-0.82). No association was observed between treatment persistence and cotreatment with antidiabetic or antithrombotic drugs, baseline low-density lipoprotein levels, or total cholesterol levels. However, persistence was influenced by the type of statin first prescribed. Conclusions: Our analysis of a cohort of healthy male workers revealed poor statin persistence. These findings underscore the need for a better understanding of patterns of statin use, especially in apparently healthy individuals, and for the incorporation of patient behavior into prescribing decisions (AU)

Microfluidics technology for drug delivery: A review.

Microfluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory bench-top technology on a miniature chip-scale device. In the area of drug delivery science, microfluidics offers advantages, such as precise dosage, ideal delivery, target-precise delivery, sustainable and controlled release, multiple dosing, and slight side effects. These advantages bring significant assets to the drug delivery systems. Microfluidic technology has been progressively used for fabrication of drug carriers, direct drug delivery systems, high-throughput screening, and formulation and immobilization of drugs. This review discusses the recent technological progress, outcomes and available opportunities for the usage of microfluidics systems in drug delivery systems.

Persistence With Statins in Primary Prevention of Cardiovascular Disease: Findings From a Cohort of Spanish Workers.

INTRODUCTION AND OBJECTIVES: The aim of this study was to assess patterns of treatment persistence in a cohort of male Spanish workers receiving statin therapy for primary prevention of cardiovascular disease. METHODS: This descriptive study was conducted within the framework of the prospective longitudinal Aragon Workers' Health Study (N = 5400). Incident male statin users were identified based on data collected from the regional government's medication consumption information system. Patterns of treatment persistence with statins prescribed for primary cardiovascular disease prevention were assessed and the relevance of potential predictors explored. RESULTS: Among the 725 new statin users, less than one third remained persistent during the 1 year of follow-up. About 15% of nonpersistent users discontinued statin therapy after dispensation of the first prescription; of these, 42.1% did not recommence treatment within the following year. Factors reducing the likelihood of treatment discontinuation were older age (HR, 0.55; 95%CI, 0.39-0.77) and cotreatment with antihypertensive drugs (HR, 0.68; 95%CI, 0.56-0.82). No association was observed between treatment persistence and cotreatment with antidiabetic or antithrombotic drugs, baseline low-density lipoprotein levels, or total cholesterol levels. However, persistence was influenced by the type of statin first prescribed. CONCLUSIONS: Our analysis of a cohort of healthy male workers revealed poor statin persistence. These findings underscore the need for a better understanding of patterns of statin use, especially in apparently healthy individuals, and for the incorporation of patient behavior into prescribing decisions.

Drug Delivery and Cosmeceutical Applications of Poly- Lactic Acid Based Novel Constructs - A Review.

BACKGROUND: Poly (lactic acid) (PLA) based novel constructs have been engineered for targeted applications in various biomedical sectors of the modern world. In this context, a special focus has been given to pharmaceutical and cosmeceutical industries. METHODS: In this review, we extensively reviewed, analyzed and compiled salient information from the authentic bibliographic sources including PubMed, Scopus, Elsevier, Springer, Bentham Science and other scientific databases. A focused review question and inclusion/exclusion criterion were adopted to appraise the quality of retrieved peer-reviewed research literature. RESULTS: Recently, bio-based constructs are being engineered for target applications in different bio- and non-bio sectors of the modern world to address the growing human health-related serious concerns. The utilization of properly designed and structured materials thus allows the creation of a well-defined environment that induces a series of directed measures, and so on. Over the last few years, PLA-based novel constructs have received exceptional attention as potential candidates for various biotechnological and biomedical applications at large and drug delivery in particular. Owing to their unique characteristics including biocompatibility, together with the adjustable thermomechanical and tunable control drug release, PLA has raised interesting applications in many sectors of the medical world. So far, many of such PLA-based bio-constructs have been exploited in drug delivery systems, cosmeceutical products, and therapeutic uses. In recent years, many new applications have been reported for PLA-based materials at the micro- and nano- level, resulting in novel requests for specific drug delivery and cosmeceutical sectors. CONCLUSIONS: In summary, this review summarizes recent research on different aspects of PLA and PLA-based novel constructs and their potential biomedical applications. Moreover, with the aid of nanotechnology, PLA has made a positive impact in emerging sectors such as cosmetics, drug delivery technologies, and healthcare advances.

Effect of Supercritical Carbon Dioxide Extraction Parameters on the Biological Activities and Metabolites Present in Extracts from Arthrospira platensis.

Arthrospira platensis was used to obtain functional extracts through supercritical carbon dioxide extraction (SFE-CO2). Pressure (P), temperature (T), co-solvent (CX), static extraction (SX), dispersant (Di) and dynamic extraction (DX) were evaluated as process parameters through a Plackett-Burman design. The maximum extract yield obtained was 7.48 ± 0.15% w/w. The maximum contents of bioactive metabolites in extracts were 0.69 ± 0.09 µg/g of riboflavin, 5.49 ± 0.10 µg/g of α-tocopherol, 524.46 ± 0.10 µg/g of ß-carotene, 1.44 ± 0.10 µg/g of lutein and 32.11 ± 0.12 mg/g of fatty acids with 39.38% of palmitic acid, 20.63% of linoleic acid and 30.27% of γ-linolenic acid. A. platensis extracts had an antioxidant activity of 76.47 ± 0.71 µg GAE/g by Folin-Ciocalteu assay, 0.52 ± 0.02, 0.40 ± 0.01 and 1.47 ± 0.02 µmol TE/g by DPPH, FRAP and TEAC assays, respectively. These extracts showed antimicrobial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Candida albicans ATCC 10231. Overall, co-solvent was the most significant factor for all measured effects (p < 0.05). Arthrospira platensis represents a sustainable source of bioactive compounds through SFE using the following extraction parameters P: 450 bar, CX: 11 g/min, SX: 15 min, DX: 25 min, T: 60 °C and Di: 35 g.

Television viewing time as a risk factor for frailty and functional limitations in older adults: results from 2 European prospective cohorts.

BACKGROUND: Sedentariness is an important risk factor for poor health. The main objective of this work was to examine the prospective association between television viewing time and indicators of physical function, mobility, agility, and frailty. METHODS: Data came from two independent cohorts of community-dwelling older adults: the Seniors-ENRICA (n = 2392, 3.5 year follow-up), and the ELSA (n = 3989, 3.9 year follow-up). At baseline, television viewing and other sedentary behaviors were ascertained using interviewer-administered questionnaires. In the Seniors-ENRICA cohort overall physical function at baseline and follow-up was assessed using the physical component summary (PCS) of the SF-12 Health Survey. Measures for incident mobility and agility limitations in both cohorts were based on standardized questions, and incident frailty was measured with the Fried criteria. Analyses were adjusted for the main confounders, including physical activity at baseline. Results across cohorts were pooled using a random effects model. RESULTS: Lower (worse) scores in the PCS were observed among those in the highest (vs. the lowest) tertile of television viewing time (b-coefficient:-1.66; 95% confidence interval:-2.81,-0.52; p-trend = 0.01). Moreover, the pooled odds ratios (95% CIs) for mobility limitations for the second and third (vs. the lowest) tertile of television viewing were 1.00 (0.84, 1.20) and 1.17 (1.00, 1.38); p-trend = 0.12, respectively. The corresponding results for agility limitations were 1.18 (0.97, 1.44) and 1.25 (1.03, 1.51); p-trend = 0.02. Results for incident frailty were 1.10 (0.80, 1.51) and 1.47 (1.09, 1.97); p-trend = 0.03. No association between other types of sedentary behavior (time seated at the computer, while commuting, lying in the sun, listening to music/reading, internet use) and risk of functional limitations was found. CONCLUSIONS: Among older adults, longer television viewing time is prospectively associated with limitations in physical function independently of physical activity.

Using high hydrostatic pressures to retain the antioxidant compounds and to reduce the enzymatic activity of a pitaya-pineapple (Stenocereus sp.-Fragaria ananassa) beverage.

Pitaya (Stenocereus sp.) is a fruit native to arid and semiarid areas of Mexico. It has high antioxidant activity mainly due to its contents of betalains and phenolics, but its consumption is limited due to very short shelf-life and not very recognized flavor. A beverage of pitaya and pineapple was formulated to improve sensory properties. A high hydrostatic pressure (HHP) study at 400-600 MPa and 25 °C for 2-10 min was applied in the beverage and the effect on the contents of vitamin C, total phenolics and betalains, and the pectin methylesterase (PME) activity of pitaya-pineapple beverages, was evaluated. The effect of the come up time (CUT) was also studied. Vitamin C contents increased from 5% at 600 MPa-CUT to 64% at 400 MPa/CUT. Total phenolic concentrations decreased (20-48%) at all processing conditions tested at 400 MPa/CUT, total betacyanins were retained. At 500 MPa/10 min losses of betaxanthins of up to 6% occurred. The maximum PME activity decrease was 23% at 600 MPa 5 min, but an increase of PME activity 7% was observed at 400 MPa/10 min. HHP seem to be a good option to retain most of the antioxidant compounds in pitaya-pineapple beverage, but more studies are necessary to inactivate PME.

Advancement of green process through microwave-assisted extraction of bioactive metabolites from Arthrospira Platensis and bioactivity evaluation.

Bioactivity and functional properties of cyanobacterial extract mostly depends on process of extraction, temperature and solvent used (polar or non-polar). To evaluate these parameters a design of experiment (DOE; using a 2k design) was performed with Arthrospira platensis. Extraction process was optimized through microwave-assisted extraction considering solvent ratio, temperature and time of extraction with polar (PS) and non-polar (NPS). Maximum extract yield obtained was 4.32±0.25% and 5.26±0.11% (w/w) respectively for PS and NPS. Maximum content of bioactive metabolites in PS extracts were thiamine (846.57±14.12µg/g), riboflavin (101.09±1.63µg/g), C-phycocyanin (2.28±0.10µg/g) and A-phycocyanin (4.11±0.03µg/g), while for NPS extracts were α-tocopherol (37.86±0.78µg/g), ß-carotene (123.64±1.45µg/g) and 19.44±0.21mg/g of fatty acids. A. platensis PS extracts showed high antimicrobial activity and PS extracts had antioxidant activity of 0.79±0.12µmolTE/g for FRAP assay, while for NPS extracts 1.03±0.08µmol α-TE/g for FRAP assay.

Marine-Derived Bioactive Peptides for Biomedical Sectors: A Review.

Marine-based resources such as algae and other marine by-products have been recognized as rich sources of structurally diverse bioactive peptides. Evidently, their structural characteristics including unique amino acid residues are responsible for their biological activity. Several of the above-mentioned marine-origin species show multi-functional bioactivities that are useful for a new discovery and/or reinvention of biologically active ingredients, nutraceuticals and/or pharmaceuticals. Therefore, in recent years, marine-derived bioactive peptides have gained a considerable attention with high-value biomedical and/or pharmaceutical potentials. Furthermore, a wider spectrum of bioactive peptides can be produced through proteolytic-assisted hydrolysis of various marine resources under controlled physicochemical (pH and temperature of the reaction media) environment. Owing to their numerous health-related beneficial effects and therapeutic potential in the treatment and/or prevention of many diseases, such marine-derived bioactive peptides exhibit a wider spectrum of biological activities such as anti-cancerous, anti-proliferative, anti-coagulant, antibacterial, antifungal, and anti-tumor activities among many others. Based on emerging evidence of marine-derived peptide mining, the above-mentioned marine resources contain noteworthy levels of high-value protein. The present review article mainly summarizes the marine-derived bioactive peptides and emphasizing their potential applications in biomedical and/or pharmaceutical sectors of the modern world. In conclusion, recent literature has provided evidence that marine-derived bioactive peptides play a critical role in human health along with many possibilities of designing new functional nutraceuticals and/or pharmaceuticals to clarify potent mechanisms of action for a wider spectrum of diseases.

Factores de estado de ánimo precompetitivo en adolescentes de deportes colectivos y satisfacción con el rendimiento / Pre-competitive mood states in adolescents in team sports and satisfaction with performance / Factores de estado de humor pré-competitivo em adolescentes de desportos colectivos e satisfação com o rendimento

Esta investigación estuvo guiada por el modelo teórico de Lane y Terry (2000) y se realizó con el objetivo de estudiar el perfil de estado de ánimo en deportistas adolescentes, así como su vínculo con el rendimiento posterior en competición. Participaron en el estudio 212 deportistas, 82.5% hombres y 17.5% mujeres, con edades comprendidas entre 13 y 18 años (M = 15.44; DE = 1.14). Todos respondieron al cuestionario de estados de ánimo POMS y a 2 indicadores subjetivos de rendimiento. En base a sus puntuaciones en el factor de Estado Deprimido, la muestra de participantes fue dividida en 2 grupos, No-Deprimido (n = 104) y Deprimido (n = 108). El grupo Deprimido informó de valores significativamente más altos en los factores Tensión, Cólera y Fatiga, y significativamente más bajos en Vigor. En cuanto a la magnitud de las correlaciones entre factores, el coeficiente global fue más alto para el grupo Deprimido; aunque la diferencia observada no resultó estadísticamente significativa. Por último, en el grupo No-Deprimido encontramos relaciones significativas entre el factor Amistad del POMS y el nivel de satisfacción con el rendimiento

This research was driven by Lane and Terry’s (2000) theoretical model, and was carried out with the aim of studying the profile of mood states in adolescent athletes, in addition to the relationship between mood dimensions and sports performance. 212 athletes (82.5% men, 17.5% women) with an average age of 15.44 (SD = 1.14) took part. All of them completed the POMS questionnaire on mood states and 2 subjective performance indicators. On the basis of scores on Depressed Mood, the sample of participants was divided up into 2 groups, Non-Depressed (n = 104) and Depressed (n = 108). The Depressed group reported significantly higher values for Tension, Anger, and Fatigue, and significantly lower values for Vigour. With respect to the size of the correlations amongst factors, the overall coefficient was higher in the Depressed-mood group, although the difference observed was not statistically significant. Finally, we found significant relationships between the POMS Friendship factor and satisfaction with performance in the Non-Depressed group

Esta investigação teve por base o modelo teórico de Lane e Terry (2000) e foi realizada com o objectivo de estudar o perfil de estados dehumor em desportistas adolescentes, assim como o seu vínculo com o rendimento posterior em competição. Participaram no estudo 212 desportistas,82,5% homens e 17.5% mulheres, com idades compreendidas entre os 13 e os 18 anos (M = 15.44; DP = 1.14). Todos responderam ao questionário deestados de humor POMS e a 2 indicadores subjectivos de rendimento. Com base nas suas pontuações no factor Estado Deprimido, a amostra de partici-pantes foi dividida em dois grupos, Não--Deprimido (n = 104) e Deprimido (n = 108). O grupo Deprimido apresentou valores significativamente maiselevados nos factores Tensão, Hostilidade e Fadiga, e significativamente mais baixos para o Vigor. Quanto à magnitude das correlações entre factores,o coeficiente global foi mais elevado para o grupo Deprimido; embora não sendo diferença observada estatisticamente significativa. Por último, nogrupo Não-Deprimido verificamos relações significativas entre o factor Amizade do POMS e o nível de satisfação com o rendimento

Versión breve en español del cuestionario POMS para deportistas adultos y población general / Abbreviated version in spanish of the Poms questionnaire for adult athletes and general population

Este artículo ofrece una versión breve del cuestionario de perfil de estados de ánimo POMS en español. Se trata de un nuevo estudio sobre la validez interna de este instrumento con deportistas y presenta evidencia favorable para extender su uso a la población general no-deportista. Los participantes respondieron a la forma del cuestionario para adultos, con 44 ítems y 6 factores de primer orden, denominados Cólera, Fatiga, Vigor, Amistad, Tensión, y Estado Deprimido (Andrade et al., 2010). En la muestra de deportistas (n = 400), los resultados del análisis factorial confirmatorio fueron aceptables, aunque proporcionaron pautas para refinar el modelo de medida. Así, se procedió a reducir el número de ítems, manteniendo sólo 5 por cada dimensión teórica, aquellos que fueron estadística y sustantivamente más apropiados. De este modo también se consiguió un incremento significativo de la bondad de ajuste del modelo. En una segunda fase se realizó el análisis factorial confirmatorio del patrón obtenido en una muestra de población general (n = 400). Finalmente, empleamos la aproximación multigrupo para comprobar la invarianza del modelo a dos niveles, configuración y equivalencia métrica (AU)

This paper reports on an abbreviated Spanish form of the questionnaire for the profile of mood states, POMS. It is a new study on the internal validity of this instrument with athletes, and offers evidence to extend its use to the general population. The participants completed the POMS adult version, with 44 items and 6 first-order factors labelled Anger, Fatigue, Vigour, Friendliness, Tension, and Depressed Mood (Andrade et al., 2010). In the athletes’ sample (n = 400), the results of the confirmatory factor analysis were acceptable, although they provided guidelines to refine the measurement model. Thus, we proceeded to reduce the number of items, keeping only 5 for each theoretical dimension: the most statistically and substantively appropriate ones. This way we also achieved a significant increase in the goodness-of-fit of the model. Subsequently, we carried out confirmatory factor analysis of the same pattern in the general population sample (n = 400). Finally, we used a multi-group approach to test the invariance of the model on two levels, configuration and metric equivalence (AU)

Adaptation of the Athlete Burnout Questionnaire in a Spanish sample of athletes.

In this paper, we offer a general version of the Spanish adaptation of Athlete Burnout Questionnaire (ABQ) designed to measure the syndrome of burnout in athletes of different sports. In previous works, the Spanish version of ABQ was administered to different samples of soccer players. Its psychometric properties were appropriate and similar to the findings in original ABQ. The purpose of this study was to examine the generalization to others sports of the Spanish adaptation. We started from this adaptation, but we included three alternative statements (one for each dimension of the questionnaire), and we replaced the word "soccer" with the word "sport". An 18-item version was administered to a sample of 487 athletes aged 13 and 29 years old. Confirmatory factor analyses replicated the factor structure, but two items modification were necessary in order to obtain a good overall fit of the model. The internal consistency and test-retest reliability of the questionnaire were satisfactory.

Adaptation of the athlete burnout questionnaire in a spanish sample of athletes

In this paper, we offer a general version of the Spanish adaptation of Athlete Burnout Questionnaire (ABQ) designed to measure the syndrome of burnout in athletes of different sports. In previous works, the Spanish version of ABQ was administered to different samples of soccer players. Its psychometric properties were appropriate and similar to the findings in original ABQ. The purpose of this study was to examine the generalization to others sports of the Spanish adaptation. We started from this adaptation, but we included three alternative statements (one for each dimension of the questionnaire), and we replaced the word «soccer» with the word «sport». An 18-item version was administered to a sample of 487 athletes aged 13 and 29 years old. Confirmatory factor analyses replicated the factor structure, but two items modification were necessary in order to obtain a good overall fit of the model. The internal consistency and test-retest reliability of the questionnaire were satisfactory (AU)

En el presente estudio se ofrece una versión genérica de la adaptación española del Athlete Burnout Questionnaire (ABQ) para medir el síndrome de burnout en diversas modalidades deportivas. En investigaciones anteriores, la versión española del ABQ fue aplicada a diferentes muestras de futbolistas españoles, logrando unas propiedades psicométricas adecuadas, similares a las encontradas en el ABQ original. El objetivo de este trabajo consistió en comprobar el grado de generalización a otros deportes de la adaptación española. Se partió de esta adaptación a la que se le añadieron tres ítems con enunciados alternativos (uno para cada dimensión del cuestionario) y se sustituyó la palabra fútbol por deporte. Este cuestionario de 18 ítems fue aplicado a 487 deportistas con un rango de edad entre los 13 y los 29 años. Análisis factoriales confirmatorios replicaron la estructura factorial, pero fueron necesarias dos re-especificaciones para conseguir un buen ajuste. En cuanto a la fiabilidad, se refirieron valores aceptables tanto de consistencia interna como de estabilidad (AU)