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Rev Neurol ; 68(1): 1-6, 2019 Jan 01.
Article in Spanish | MEDLINE | ID: mdl-30560982

ABSTRACT

INTRODUCTION: There is great interest in studies on the implications that gut microbiota exerts on the behavior of people with autism spectrum disorders (ASD), through the microbiota-gut-brain axis. Most studies on microbiota are focused on the possible involvement of bacteria on people with ASD, but few of them are focussed on the effect of microorganisms in the Fungi kingdom. SUBJECTS AND METHODS: The present study performs a systematic review of the presence of Candida spp. in people with ASD using the PRISMA method. RESULTS: A total of three articles were found after applying the exclusion and inclusion criteria of the systematic review. Two studies coincided in reporting significant differences in the increase in the frequency of the Candida spp. genus in people with ASD. while the third study did not report significant differences of Candida spp. genus between people with ASD. CONCLUSIONS: Although there is a clear lack of investigation of both the Candida ssp. genus and the whole Fungi kingdom in people with ASD, the studies point to an important presence of this genre in this group. Specifically, in the results found in this review, the highest prevalence of the C. albicans in children with ASD stands out. However, little is still known about the involvement of Candida spp., and other types of fungi, on gastrointestinal symptoms and ASD symptoms, in children with ASD.


TITLE: Candida spp. en la microbiota intestinal de las personas con autismo: revision sistematica.Introduccion. Existe gran interes en los estudios sobre las implicaciones que la microbiota intestinal ejerce en el comportamiento de personas con trastornos del espectro autista (TEA) a traves del eje microbiota-intestino-cerebro. La mayoria de los estudios sobre microbiota estan enfocados en la posible implicacion de las bacterias sobre personas con TEA, pero pocos versan sobre el efecto de los microorganismos del reino Fungi. Sujetos y metodos. Se realiza una revision sistematica mediante el protocolo PRISMA de la presencia de Candida spp. en las personas con TEA. Resultados. Se encontro un total de tres articulos tras aplicar los criterios de exclusion e inclusion de la revision sistematica. Dos estudios coincidieron en mostrar diferencias significativas en el aumento de la frecuencia del genero Candida spp. en personas con TEA, mientras que en otro no se hallaron diferencias. Conclusiones. Pese a que existe una clara falta de investigacion tanto del genero Candida ssp. como de todo el reino Fungi en las personas con TEA, los estudios apuntan a una importante presencia de dicho genero en este colectivo. Concretamente, en los resultados encontrados se destaca la mayor prevalencia del genero C. albicans en los niños con TEA. Sin embargo, aun se sabe poco sobre la implicacion de Candida spp. y otros tipos de hongos sobre los sintomas gastrointestinales y la sintomatologia del autismo en niños con TEA.


Subject(s)
Autistic Disorder/microbiology , Candida , Gastrointestinal Microbiome , Humans
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