ABSTRACT
Background: Cardiovascular disease (CVD) is one of the principal causes of death in antineutrophil cytoplasmic antibody-(ANCA)-associated vasculitis (AAV). Objectives: To evaluate the mortality and it's causes and CVD and its vascular risk factors (VRFs) in AAV patients in Andalusia. Methods: A multicenter cohort of 220 AAV patients followed-up from 1979 until June 2020 was studied in Andalussia, south of Spain. The information, including socio-demographic and clinical data was recorded retrospectively through chart review. Data was analysed using Chi2, ANOVA and Cox proportional hazards regresion as uni and multivariate test with a 95% confidence interval (CI). Results: During a mean ± standard deviation follow-up of 96.79 ± 75.83 months, 51 patients died and 30 presented at least one CVE. Independent prognostic factors of mortality were age (HR 1.083, p=0.001) and baseline creatinine (HR 4.41, p=0.01). Independent prognostic factors of CVE were age [hazard ratio (HR) 1.042, p=0.005] and the presence of hypertension (HTN) six months after diagnosis (HR 4.641, p=0.01). HTN, diabetes and renal failure, all of these important VRFs, are more prevalent in AAV patients than it is described in matched general population. Conclusions: Age and baseline renal function, but not CVEs, are predictors of mortality and age and early HTN are independent predictors for having a CVE. CVD screening in AAV patients is demanded.(AU)
Introducción: La enfermedad cardiovascular (ECV) es una de las principales causas de muerte en las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilos (ANCA) (VAA). Objetivos: Evaluar la mortalidad y sus causas, entre ellas la ECV y sus factores de riesgo vascular (FRV) en pacientes con VAA en Andalucía. Métodos: Se estudió una cohorte multicéntrica de 220 pacientes con VAA seguidos desde 1979 hasta junio de 2020 en Andalucía. La información, incluidos los datos sociodemográficos y clínicos, se registró retrospectivamente a través de la revisión de historias clínicas. Los datos se analizaron mediante Chi2, ANOVA y regresión de riesgos proporcionales de Cox de forma uni y multivariante con un intervalo de confianza (IC) del 95%. Resultados: Durante un seguimiento medio y desviación estándar de 96,79 ± 75,83 meses, 51 pacientes fallecieron y 30 presentaron al menos un ECV. Los factores pronósticos independientes de mortalidad fueron la edad (HR 1,083, p=0,001) y la creatinina basal (HR 4,41, p=0,01). Los factores pronósticos independientes de ECV fueron la edad [hazard ratio (HR) 1,042, p=0,005] y la presencia de hipertensión arterial (HTA) seis meses después del diagnóstico (HR 4,641, p=0,01). La prevalencia de HTA, diabetes e insuficiencia renal fue elevada o muy elevada en comparación con la población general emparentada, todos FRCV determinantes para el pronóstico de estos pacientes. Conclusiones: La edad y la función renal basal son predictores de mortalidad y la edad y la HTA de aparición precoz son predictores independientes de tener ECV. Se recomienda el cribado de FRCV en pacientes con vasculitis ANCA.(AU)
Subject(s)
Humans , Male , Female , Cardiovascular Diseases/mortality , Hypertension , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Spain , Cohort Studies , Risk FactorsABSTRACT
BACKGROUND: Cardiovascular disease (CVD) is one of the principal causes of death in antineutrophil cytoplasmic antibody-(ANCA)-associated vasculitis (AAV). OBJECTIVES: To evaluate the mortality and it's causes and CVD and its vascular risk factors (VRFs) in AAV patients in Andalusia. METHODS: A multicenter cohort of 220 AAV patients followed-up from 1979 until June 2020 was studied in Andalussia, south of Spain. The information, including socio-demographic and clinical data was recorded retrospectively through chart review. Data was analysed using Chi2, ANOVA and Cox proportional hazards regresion as uni and multivariate test with a 95% confidence interval (CI). RESULTS: During a mean ± standard deviation follow-up of 96.79 ± 75.83 months, 51 patients died and 30 presented at least one CVE. Independent prognostic factors of mortality were age (HR 1.083, p=0.001) and baseline creatinine (HR 4.41, p=0.01). Independent prognostic factors of CVE were age [hazard ratio (HR) 1.042, p=0.005] and the presence of hypertension (HTN) six months after diagnosis (HR 4.641, p=0.01). HTN, diabetes and renal failure, all of these important VRFs, are more prevalent in AAV patients than it is described in matched general population. CONCLUSIONS: Age and baseline renal function, but not CVEs, are predictors of mortality and age and early HTN are independent predictors for having a CVE. CVD screening in AAV patients is demanded.
Subject(s)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Cardiovascular Diseases , Hypertension , Humans , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/epidemiology , Antibodies, Antineutrophil Cytoplasmic , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/etiology , Heart Disease Risk Factors , Hypertension/complications , Hypertension/epidemiology , Kidney , Retrospective Studies , Risk Factors , Spain/epidemiologyABSTRACT
No disponible
Subject(s)
Male , Middle Aged , Humans , Amyloidosis/diagnosis , Pleural Effusion/etiologySubject(s)
Cocaine-Related Disorders/complications , Pulmonary Edema/chemically induced , Renal Insufficiency/chemically induced , Cocaine-Related Disorders/diagnostic imaging , Cocaine-Related Disorders/therapy , Humans , Male , Middle Aged , Pulmonary Edema/diagnostic imaging , Pulmonary Edema/therapy , Radiography, Thoracic , Renal Insufficiency/therapy , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Adult , Aged , Male , Female , Humans , Thoracoscopy , Thyroidectomy , Thyroid Gland , HIV Infections , Treatment Outcome , Carcinoma, Papillary , Diagnosis, Differential , Facial Paralysis , Thyroid Neoplasms , Pleural NeoplasmsABSTRACT
Sweet's syndrome, or febrile neutrophilic dermatosis, is a process characterized by fever, red tender plaques, neutrophilia and neutrophilic dermal infiltrate with papilar edema in the absence of vasculitis. The association with intestinal inflammatory disease is inusual, a new case associated with ulcerative colitis is reported, and we perform a literature review of Sweet's associated intestinal inflammatory disease.
Subject(s)
Inflammatory Bowel Diseases/complications , Sweet Syndrome/complications , Female , Humans , Middle AgedABSTRACT
El síndrome de Sweet o dermatosis neutrofílica aguda febril es un proceso caracterizado por fiebre, placas eritematosas dolorosas, neutrofilia y un infiltrado dérmico constituido por neutrófilos con edema papilar sin vasculitis. Su asociación con la enfermedad inflamatoria intestinal es inusual, presentamos un nuevo caso de síndrome de Sweet asociado a colitis ulcerosa, y realizamos una revisión de los casos descritos en la literatura asociados a enfermedad inflamatoria intestinal (AU)
No disponible
Subject(s)
Middle Aged , Female , Humans , Inflammatory Bowel Diseases , Sweet SyndromeSubject(s)
Anti-Bacterial Agents/therapeutic use , Endocarditis, Bacterial/drug therapy , Q Fever/drug therapy , Anti-Infective Agents/administration & dosage , Anti-Infective Agents/therapeutic use , Doxycycline/therapeutic use , Drug Therapy, Combination/therapeutic use , Humans , Lincomycin/therapeutic use , Quinolones/administration & dosage , Quinolones/therapeutic useABSTRACT
No disponible
Subject(s)
Aged , Male , Humans , Somatostatin , Thyrotropin , Peptides, Cyclic , Prolactin , Antineoplastic Agents , Adenoma , Pituitary NeoplasmsABSTRACT
Embolism is very frequently found in patients with infective endocarditis (IE), fundamentally in cerebral arteries. An early diagnosis and possible complications seem to be related to morbidity and mortality. Echocardiography has a considerable function in early diagnosis, and, also, when we evaluate the risk of major cerebral embolism. However there is no agreement in the second aspect: for some authors echocardiography only slightly aids, but others consider it of great value in identifying high-risk patients. We describe a patient who suffers infective endocarditis by Staphylococcus aureus with significant neurological complications in its evaluation. Vegetation was disclosed by transesophageal echocardiography (TEE), whereas transthoracic echocardiography (TTE) was unable to do so. This is why we underline the role of TEE in the diagnosis and description of vegetation features (size, mobility and implantation) which seem to be linked to the risk of cerebral complications.
Subject(s)
Echocardiography, Transesophageal , Endocarditis, Bacterial/diagnostic imaging , Intracranial Embolism and Thrombosis/diagnostic imaging , Staphylococcal Infections/diagnostic imaging , Adult , Endocarditis, Bacterial/complications , Humans , Intracranial Embolism and Thrombosis/etiology , Male , Risk Assessment , Staphylococcal Infections/complicationsABSTRACT
A case of ampullary cancer, the first clinical manifestation of which was two episodes of acute pancreatitis is presented with review of the literature on the possible role of this type of cancer as a causal agent of episodes of acute pancreatitis. We support the use of ERCP in all patients with acute idiopathic pancreatitis with the aim of discarding the possibility of a tributary ampullary tumor of curative removal.
