ABSTRACT
AIM: This paper describes the experience at a district general hospital of coping with an abrupt onset of calcification of Hydroview intraocular lens (IOL) implants requiring exchange surgery mostly for symptoms of glare, even though the visual acuities were relatively good. METHODS: In this retrospective study, the operative details of 174 consecutive lens exchanges by one surgeon were retrieved from the surgeon's notes. Of these, pre and post-operative details of 106 consecutive patients were obtained from the hospital notes. RESULTS: Of the 174 lens exchanges, all were sutureless except one and 31 eyes (18%) had had previous capsulotomies. Of 143 eyes with intact posterior capsules, eight (5.6%) needed anterior vitrectomy. Lens replacements were in the bag in 136 (95%), in the sulcus in five (3.5%), and in the anterior chamber in two (1.5%). Of the 31 eyes with previous capsulotomies, 10 (32%) needed anterior vitrectomy. Lens replacements were in the bag in 22 (71%) and in the sulcus in the remaining nine cases (29%). Postoperatively the best-corrected visual acuity was improved in 53%, remained the same in 35%, and deteriorated in 12%. CONCLUSION: The lens exchange procedure was mostly predictable with satisfactory visual results allowing preoperative counselling of risks to be similar to that for cataract surgery. The onset and resolution of the period of implantation of lenses requiring exchange has not been explained.
Subject(s)
Calcinosis/etiology , Device Removal/methods , Lenses, Intraocular/adverse effects , Aged , Aged, 80 and over , Device Removal/economics , Device Removal/statistics & numerical data , Fatty Acids/metabolism , Female , Follow-Up Studies , Hospitals, District , Humans , Hydrogel, Polyethylene Glycol Dimethacrylate/metabolism , Lenses, Intraocular/standards , Liability, Legal , Male , Middle Aged , Prosthesis Failure , Reoperation/methods , Retrospective Studies , Visual AcuityABSTRACT
AIM: To describe a new technique of suturing a tear in the anterior capsulorhexis. METHODS: Continuous curvilinear capsulorhexis (CCC) with lens removal was done in five fresh cadaver eyes. The diameter of the CCC was measured with a calliper. Using the same calliper a tear of the CCC was created while opening the calliper's arms. The distance between the calliper's arms needed to tear the CCC was documented. Using 9-0 Ethilon 9011, CS 160-6 sutures in two eyes, 9-0 Prolene, D-8229, CTC-6L sutures in two eyes, and 10-0 Prolene, 9090, CTC-6 suture in one eye, the tears were sutured. A tear in the CCC was created again in the same way as the first tear. The distance between the calliper's arms needed to tear the CCC was documented again. RESULTS: Suturing of the tear restored some of the strength/elasticity of the CCC. Better results were found while using the 9-0 Prolene, D-8229, CTC-6L sutures than with the two others sutures. CONCLUSIONS: Suturing of a broken CCC can restore at least some of the strength/elasticity of the CCC. This can be important before intraocular lens (IOL) implantation for the safety of the implantation or after the implantation to ensure proper fixation of the IOL.
Subject(s)
Capsulorhexis/methods , Intraoperative Complications/surgery , Suture Techniques , Biomechanical Phenomena , Elasticity , Humans , SuturesABSTRACT
AIM: To describe unique linear deposits on the surface of posterior chamber intraocular lenses (IOLs) occurring after implantation through a hexagonal cartridge. METHODS: Five ACR6D SE IOLs (Corneal Laboratories, Pringy, France) were injected/implanted through hexagonal cartridges. Two of these were injected into a petri dish and the remaining three were inserted into the evacuated capsular bag of cadaver eyes. In addition, three other ACR6D SE IOLs were injected into a petri dish through round cartridges. The latter served as controls. RESULTS: All lenses that were injected/implanted through the hexagonal cartridges demonstrated linear deposits on the posterior surface of the IOL optic component. The IOLs that were injected through the round cartridges had no deposits. All the hexagonal cartridges showed signs of internal cracking. None of the round cartridges were cracked. CONCLUSION: Implantation of at least one IOL model, the ACR6D SE IOL, through a hexagonal cartridge can result in linear deposits on the posterior optical surface of the IOL. The shape of the cartridge appears to be a significant factor in causing the depositions.
Subject(s)
Lens Implantation, Intraocular/instrumentation , Lenses, Intraocular , Artifacts , Humans , Lens Implantation, Intraocular/methods , Methacrylates , Microscopy, Electron, Scanning , Prosthesis Failure , Surface PropertiesABSTRACT
PURPOSE: To report histologic findings in 14 AlphaCor artificial corneas implanted during clinical trials and subsequently explanted from human subjects following complications, so as to evaluate biointegration within the device skirt. METHODS: Explants were fixed and sectioned in paraffin. Histologic findings related to the device skirt were compared with earlier histologic results from animal studies and correlated with clinical histories. RESULTS: Two devices had been removed due to complications related to the optic alone, 11 following stromal melting overlying the biointegratable sponge skirt and 1 due to a retroprosthetic membrane. All devices demonstrated normal skirt porosity. Biointegration was similar to that found in animal studies but qualitatively appeared reduced in the affected areas in patients with overlying stromal melting prior to explantation. Patients with a longer history of melting prior to explantation demonstrated presence of inflammatory cells around the device. CONCLUSIONS: Histologic findings of the AlphaCor skirt in humans are consistent with earlier animal studies. This study confirms that biointegration by host fibroblastic cells, with collagen deposition occurs after AlphaCor implantation in humans. In cases in which stromal melting had occurred, biointegration is seen to be reduced. On correlating preoperative clinical factors with biointegration observed histologically, preoperative vascularization appears not to be required for AlphaCor biointegration.
Subject(s)
Cornea/pathology , Prostheses and Implants/ultrastructure , Prosthesis Implantation/instrumentation , Aged , Aged, 80 and over , Animals , Cornea/surgery , Female , Follow-Up Studies , Humans , In Vitro Techniques , Male , Middle Aged , Prosthesis Design , RabbitsABSTRACT
PURPOSE: To report and compare clinical and pathological features of hydrophilic acrylic intraocular lenses (IOLs) of three major designs, explanted from patients who had visual disturbances caused by opacification of the lens optic. METHODS: Eighty-seven hydrophilic acrylic IOLs (25 Hydroview, 54 SC60B-OUV, and 8 Aqua-Sense lenses) were explanted and sent to our center. Most patients became symptomatic during the second year after cataract surgery. A fine granularity was observed on the surface of the lens optic in the case of Hydroview. With the SC60B-OUV and Aqua-Sense lenses, the opacity resembled a nuclear cataract. Gross examination, light microscopy and staining with alizarin red and the von Kossa method (for calcium) were performed. Some lenses were submitted for scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). RESULTS: Light microscopic and SEM analyses revealed the presence of irregular granular deposits on the external optical surfaces of Hydroview lenses. With the SC60B-OUV lenses, the opacity was caused by the presence of multiple fine, granular deposits within the lens optic, distributed in a line parallel to the anterior and posterior curvatures of the optic, with a clear zone just beneath its external surfaces. The Aqua-Sense lenses exhibited both patterns simultaneously. The deposits in all cases stained positive with alizarin red and von Kossa method. EDS also demonstrated the presence of calcium and phosphates within the deposits. CONCLUSION: Differences in the water content of the hydrophilic acrylic materials used in the manufacture of these three lens designs may be responsible for the different patterns of calcium precipitation. Careful clinical follow up of patients implanted with these lenses is necessary to determine if this phenomenon is rare and sporadic or may be more widespread.
Subject(s)
Calcinosis/etiology , Cataract/etiology , Lenses, Intraocular , Prosthesis Failure , Aged , Aged, 80 and over , Cataract/pathology , Humans , Hydrogel, Polyethylene Glycol Dimethacrylate , Microscopy, Electron, Scanning , Middle Aged , Prosthesis Design , Risk FactorsABSTRACT
We describe different methods to prepare postmortem human or animal eyes used at the Center for Research in Ocular Therapeutics and Biodevices at the Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA. These techniques have been utilized for performing different surgical procedures (phacoemulsification, extracapsular cataract extraction, etc.), and for training of surgeons in-transition. Performing these techniques in the wet-laboratory contributed to improve surgical skills to perform the critical steps of the phacoemulsification surgery. Pathological evaluation of pseudophakic postmortem human eyes using the Miyake-Apple posterior view and histology was helpful to analyze postoperative complications of cataract surgery (anterior capsule opacification and posterior capsule opacification) secondary to postoperative proliferation of lens epithelial cells into the capsular bag. Modifications in the surgical techniques and/or lens design may be helpful to reduce these postoperative complications. Implantation of various aphakic and phakic intraocular lenses in postmortem human eyes as well as animal eyes was helpful to analyze the sizing and fitting of new lens designs within the eye.
Subject(s)
Anterior Eye Segment/surgery , Cataract Extraction/education , Cataract Extraction/methods , Animals , Cadaver , Cataract Extraction/adverse effects , Coloring Agents , Humans , Lenses, Intraocular , Postoperative Complications/diagnosisSubject(s)
Artifacts , Myelin Sheath/diagnostic imaging , Optic Disk/pathology , Aged , Autopsy , Eye Enucleation , Humans , Male , UltrasonographyABSTRACT
PURPOSE: The objective of this study is to evaluate the use of a topical non-steroidal anti-inflammatory drug in the treatment of induced diffuse lamellar keratitis (DLK) in an animal model. MATERIALS AND METHODS: A corneal flap was created in 40 eyes of 20 Dutch-belted rabbits using the ASC microkeratome. The interface was inoculated with either Pseudomonas Aeruginosa Lipopolysaccharide (LPS) endotoxin or Ultra Palmolive liquid dish washer. The rabbits were divided in two groups: Group I (n=20) treated with ketorolac tromethamine ophthalmic solution 0.5% 4 times a day and the group II (n=20) used as control. The rabbits were examined at the slit lamp at day 1, 3, 5 and 7 postoperatively. DLK was graded from I-IV. RESULTS: At the end of the study 31 eyes were available for evaluation. 28 eyes (90%) developed DLK: 86% of the treated group and 94% of the control group during the follow-up. The treated group showed a lower rate of DLK as well as a lower severity. However, no statistically significant difference was found when comparing both groups (P>0.05). CONCLUSION: Pseudomonas aeruginosa LPS endotoxin and Palmolive Ultra can induce DLK in rabbit eyes. The postoperative prophylactic treatment with a topical non-steroidal anti-inflammatory drug showed a tendency towards a lower DLK rate as well as the severity of the disease.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Keratitis/drug therapy , Ketorolac Tromethamine/therapeutic use , Animals , Keratitis/prevention & control , Keratomileusis, Laser In Situ , Models, Animal , Ophthalmic Solutions , Rabbits , Surgical FlapsABSTRACT
BACKGROUND: The potentially accommodative intraocular lens (IOL) is a new development in IOL design METHODS: We evaluated the new Humanoptics 1CU accommodative IOL in a laboratory study with human post mortem autopsy eyes. Using the Miyake-Apple posterior view video technique, the movement pattern of the IOL was tested and observed from the posterior perspective. RESULTS. A circular bend at the level of the ciliary body applied slight circular force onto the sclera allowing the relaxation of the zonules. The shift of focus was demonstrated by using a reading target. In addition, viscoelastic was injected into the vitreous resulting in the same anterior movement of the IOL optic. CONCLUSIONS: The 1CU Humanoptics accommodative IOL showed potential accommodative behaviour in the laboratory. The accommodative (respectively pseudoaccommodative) effect was based on the anterior shift principle with anterior movement of the IOL-optic in the state of relaxing zonules. Whether this reflects the clinical situation, especially to this extent, must be further evaluated.
Subject(s)
Accommodation, Ocular , Lens Implantation, Intraocular , Lenses, Intraocular , Autopsy , Cataract Extraction , Ciliary Body , Humans , Movement , Prosthesis Design , Video RecordingABSTRACT
PURPOSE: The aim of this experimental ani-mal study was to induce diffuse lamellar keratitis (DLK), and investigate a prophylactic treatment with corticosteroids. MATERIALS AND METHODS: A corneal flap was cut in 40 eyes from 20 Dutch-belted rabbits and the interface inoculated with either Pseudomonas aeruginosa lipopolysaccharide (LPS) endotoxin ( n=21) or Palmolive Ultra soap ( n=19). Half of the eyes were treated with topical corticosteroids and the other half remained untreated. Slitlamp examinations were performed 1, 3, 5 and 7 days postoperatively and DLK was graded from I-IV. RESULTS: At the end of the study 33 eyes were available for evaluation and 94% of the non-treated eyes developed DLK. Out of those eyes treated with steroids 19% developed DLK during the 1 week follow-up period. This was statistically significantly lower ( P=0.018) when compared to the untreated group. CONCLUSION: Pseudomonas aeruginosa LPS endotoxin as well as Palmolive((R)) Ultra caused a very high rate of DLK in rabbit eyes. The postoperative prophylactic treatment with corticosteroids showed a statistically significant lower DLK rate in this rabbit eye model.
Subject(s)
Adrenal Cortex Hormones/therapeutic use , Keratitis/etiology , Keratitis/prevention & control , Keratomileusis, Laser In Situ , Postoperative Complications/etiology , Postoperative Complications/prevention & control , Adrenal Cortex Hormones/administration & dosage , Animals , Endotoxins , Follow-Up Studies , Keratomileusis, Laser In Situ/adverse effects , Lipopolysaccharides , Pseudomonas aeruginosa , Rabbits , Soaps , Time FactorsABSTRACT
Intraocular lens (IOL) implantation has no doubt been one of the most satisfying advances of medicine. Millions of individuals with visual disability or frank blindness from cataracts had and continue to have benefit from this procedure. It has been reported by ophthalmologists that the modern cataract-intraocular lens (IOL) surgery is safe and complication-free most of the time. This makes the watchword for any cataract surgeon to be 'implantation,' 'implantation,' 'implantation.' In the mid-1980s, as IOLs were evolving rapidly, the watchword of the implant surgeon was 'fixation,' 'fixation,' 'fixation.' Most techniques, lenses and surgical adjuncts now allow us to achieve the basic requirement for successful IOL implantation, namely long-term stable IOL fixation in the capsular bag. However despite this advancement some items 'slipped through cracks.' In this article, we would like to alert the reader to a new watchword, namely 'opacification,' 'opacification,' 'opacification.' Here we will be talking about the good, the bad, and the ugly. Examples of the 'good' include the recent successes now being achieved in reducing the incidence of posterior capsule opacification. Examples of the 'bad' include various proliferations of anterior capsule cells, problems caused by silicone oil adherence to IOLs and problems with piggyback IOLs. The 'ugly' include the sometimes striking and often visually disabling opacifications occurring on and within IOL optics, both on some modern foldable IOLs as well as a poly(methyl methacrylate) (PMMA) optic degradation occurring with some models a decade or more after implantation.
Subject(s)
Cataract Extraction , Cataract/etiology , Lens Implantation, Intraocular , Postoperative Complications/pathology , Cataract/pathology , Cataract/prevention & control , Humans , Postoperative Complications/prevention & control , Silicones/adverse effects , Time FactorsABSTRACT
On may 25th 2001 Sir Harold Ridley died at age 94. With him Ophthalmology lost one of the greatest and most influential Ophthalmologist of the post-war time. He is the founder of modern cataract surgery implanting the first intraocular lens after extracapsular cataract extraction 50 years ago. He pioneered in what became one of the most important success stories in Ophthalmology. His vision and concepts managed to succeed against strong opposition worldwide. Modern cataract surgery and modern refractive IOL surgery would not been possible without his contribution. Sir Harold Ridley reached a high age and was therefore able to see his visions become reality and finally receive all honours and awards he deserved over the past 15 years, including the knighthood by Queen Elisabeth II in the year 2000. The following article gives a summary of his biography and contributions to Ophthalmology.
Subject(s)
Lenses, Intraocular/history , Ophthalmology/history , Cataract Extraction/history , England , History, 20th Century , History, 21st Century , Humans , Lens Implantation, Intraocular/historyABSTRACT
Even though cataract surgery has been practiced for over 2000 years, modern cataract surgery started just some 50 years ago. with the first IOL implantation by Sir Harold Ridley. The development of intraocular lenses was accompanied by great successes and disasters. With the fast development of cataract surgical techniques over the past 15 years (ECCE, Phacoemulsification, Capsulorhexis) a successful marriage between IOL-developments and surgery was established. Indication profiles for cataract surgery and IOL implantation extended to more and more patient groups. At this time classical cataract surgery is further developing into refractive intraocular lens surgery to correct higher ametropia in clear lens or phakic eyes. This development was only possible because of the improvements of surgical techniques and implants in classical cataract surgery.
Subject(s)
Cataract Extraction/history , Lens Implantation, Intraocular/history , Lenses, Intraocular/history , Accommodation, Ocular , Capsulorhexis/history , History, 20th Century , Humans , Phacoemulsification/historyABSTRACT
BACKGROUND: Foldable intraocular lenses (IOL) have become increasingly preferred choice for IOL implantation after cataract removal. However, both foldable as well as rigid IOLs are not yet complication-free and may need explanation. MATERIAL AND METHODS: A total of 2663 explanted posterior chamber IOLs (PCIOLs) were accessioned at the Center for Research on Ocular Therapeutics and Biodevices between January 1988 and September 2000. The lenses were examined grossly using a Leitz/Wild M-8-Zoom stereomicroscope. The clinical reasons for explanation were documented for foldable as well as for rigid lenses. RESULTS: Of a total of 2663 explanted PCIOLs, 586 were foldable lenses and 2077 were rigid PMMA lenses The most frequent reason for explantation of all 2663 IOLs studied was decentration/dislocation. Optic and haptic damage and posterior capsule rupture were significantly more often a reason for explantation in several foldable designs compared to rigid PCIOLs. Whereas rigid designs lead more often to corneal decompensation. The percentage of explanted IOLs because of inflammatory reactions decreased significantly from 1994 to 2000. CONCLUSIONS: The complication profiles of rigid and foldable IOLs revealed some apparent differences due to the nature of the IOL biomaterials and designs. IOL optic/haptic damage was a common complication for foldable IOLs, whereas it was only discovered in single digits for rigid PMMA IOLs. The possible explanation for this is, that the soft and flexible biomaterials, from which all the foldable IOLs were manufactured, are easier to be damaged during folding, unfolding and insertion procedure. In our opinion this relative disadvantage of foldable IOLs is by far outweighed by the numerous advantages of the small incision cataract surgery. The decreasing inflammatory reactions can be explained by advances in surgical techniques, especially the secure in-the-bag fixation of IOLs.
Subject(s)
Lenses, Intraocular/adverse effects , Humans , Lens Implantation, Intraocular , Polymethyl Methacrylate , Risk FactorsABSTRACT
BACKGROUND: Sir Harold Ridley's first cataract extraction with implantation of an intraocular lens (IOL) marked the beginning of a major change in the practice of ophthalmology. MATERIAL AND METHODS: Two human autopsy globes implanted with original Ridley IOLs were grossly examined from behind with the Miyake-Apple photographic technique. The anterior segments were evaluated histologically. One Ridley IOL was examined by scanning electron microscopy. RESULTS: Both IOLs maintained a clear visual axis and had been placed in the capsular sac. The right lens was decentered inferiorly, the left IOL was well centered. The posterior capsule showed only minimal capsular opacification. Scanning electron microscopy (SEM) of the explanted IOL showed a smooth, well polished surface. CONCLUSIONS: In this patient Ridley IOLs maintained an ideal visual rehabilitation of 20/20 in both eyes, 22 and 18 years postoperatively. One surprising finding was the presence of a square, truncated optic edge geometry, very similar to that seen in some modern foldable IOLs. In our opinion the absence of posterior capsule opacification of the Ridley IOL may have partially been a result of this nearly sharp optic edge, that we confirmed by SEM. Even 22 years after implantation the Ridley IOL showed a high finish quality. Many of Sir Harold Ridley's early concepts like the IOL placement in the posterior chamber and endocapsular implantation are now the standard of modern cataract surgery.
Subject(s)
Autopsy , Eye/pathology , Lenses, Intraocular , Aged , Cornea/pathology , Humans , Lens Implantation, Intraocular , Male , Microscopy, Electron, Scanning , Time FactorsABSTRACT
BACKGROUND: The ongoing and fast evolution of foldable IOL designs established the necessity to evaluate the different abilities of each lens style. The large IOL database (over 16,500 specimens) acquired in our laboratory, has permitted us to perform a clinico-pathological analysis on pseudophakic autopsy globes provided from sources worldwide, especially many Lions Eye banks in the United States. MATERIAL AND METHODS: We analyzed 6 foldable IOL styles commonly implanted in the United States, using one type of rigid IOL design (1-piece design rigid PMMA optics) as a comparison group. Posterior capsule opacification (PCO) score, decentration, fixation, presence or absence of a Nd:YAG laser posterior capsulotomy and area and intensity of Soemmerring's ring formation was discerned by examination under an operating microscope using the Miyake-Apple posterior photographic technique. RESULTS: The four lenses with the lowest rates ranging between 3.8 % and 21.7 % are modern designs, mostly implanted after 1992. The two lenses with the higher rates ranging between 23.1 % and 30.4 %, were all older designs, already prevalent prior to 1992. IOL fixation with both haptics in the capsular bag showed the best centration values and PCO scores. Our studies to date have shown in a preliminary fashion that the AcrySoftrade mark IOL displays the the lowest (best) biocompatibility score. CONCLUSIONS: Entering the new millenium, with evolution of modern surgical techniques and IOL designs, the incidence of the two major complications of cataract surgery, decentration and PCO are now finally diminishing.
Subject(s)
Lens Implantation, Intraocular/methods , Lenses, Intraocular/adverse effects , Postoperative Complications/epidemiology , Pseudophakia/complications , Autopsy , Biocompatible Materials/adverse effects , Germany/epidemiology , Humans , Incidence , Lens Implantation, Intraocular/adverse effects , Lens Implantation, Intraocular/trends , Registries , United States/epidemiologyABSTRACT
Scedosporium prolificans is a soil saprophyte that is associated with a large variety of infectious processes and with respiratory colonization in immunocompetent and immunocompromised patients. We report the first described case of S. prolificans keratouveitis associated with the intraocular long-term retention of a contact lens in a 76-year-old female patient.
Subject(s)
Contact Lenses/adverse effects , Keratitis/microbiology , Mycetoma/microbiology , Scedosporium/isolation & purification , Uveitis/microbiology , Aged , Female , Humans , Time FactorsABSTRACT
PURPOSE: To compare the intraoperative pain scores during clear corneal phacoemulsification under no anesthesia, topical anesthesia, and topical plus intracameral anesthesia. SETTING: Dr. Agarwal's Eye Hospital and Eye Research Center, Chennai, India. METHODS: Seventy-five patients were randomized to have phacoemulsification under no anesthesia, topical anesthesia, or topical plus intracameral anesthesia. Uncooperative or illiterate patients and those with hard cataract, a shallow anterior chamber, or small pupils were excluded. A protocol was established for supplemental anesthesia in case of breakthrough pain during the surgery. Each patient was asked to grade the overall severity of intraoperative pain immediately after surgery on a 10-point visual analog scale. Also evaluated were the general discomfort during surgery, discomfort from the microscope lights, surgeon stress during surgery, and total surgical time. Comparison among the 3 groups was performed using an analysis of variance. RESULTS: No supplemental anesthesia was required in any group. No significant difference was noted in the mean scores of the subjective sensation of pain with or without topical anesthesia (P =.610). The mean scores of patient discomfort from the microscope lights and surgical time were also statistically insignificant. Patient discomfort and surgeon stress during surgery were significantly greater in the no-anesthesia group than in the topical and topical plus intracameral groups (P =.0235 and P = 0.0206, respectively). CONCLUSION: No-anesthesia clear corneal phacoemulsification was performed by a highly experienced, skilled surgeon without causing an unacceptable level of pain. However, this technique is not suitable for every cataract surgeon or patient.
Subject(s)
Anesthesia, Local/methods , Anesthetics, Local/administration & dosage , Anterior Chamber/drug effects , Cornea/surgery , Phacoemulsification/methods , Adult , Aged , Double-Blind Method , Female , Humans , Lens Implantation, Intraocular , Lenses, Intraocular , Lidocaine/administration & dosage , Male , Middle Aged , Pain Measurement , Patient Satisfaction , Prospective Studies , Silicone Elastomers , Surveys and QuestionnairesABSTRACT
PURPOSE: To evaluate surface properties of various intraocular lenses (IOLs), including a newly fabricated heparin-surface-modified (HSM) silicone IOL, with special reference to their efficiency in reducing potential silicone oil adherence to the IOL optics. SETTING: Center for Research on Ocular Therapeutics and Biodevices, Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA. METHODS: Five groups of rigid and foldable IOLs were analyzed in an in vitro test for the percentage of silicone oil adherence: a single-piece foldable hydrophilic-acrylic IOL (n = 9); a single-piece rigid poly(methyl methacrylate) (PMMA) IOL with HSM coating of the lens optic (n = 9); a 3-piece foldable silicone optic IOL with HSM coating of the optic (n = 10); a single-piece standard rigid PMMA IOL (n = 7); and a standard 3-piece foldable silicone optic IOL (n = 9). After the IOLs were immersed in water and then in silicone oil, gross photographs taken. Image analysis was performed to evaluate the percentage of silicone oil coverage of the anterior and posterior surfaces of each IOL optic. RESULTS: The mean silicone oil coverage of the hydrophilic-acrylic IOLs was 5.6% +/- 2.5% (SD); of the HSM PMMA IOLs, 6.2% +/- 4.3%; of the HSM silicone optic IOLs, 6.7% +/- 3.2%; and of the standard PMMA IOLs, 20.3% +/- 13.3%. The mean silicone oil coverage was greatest on the standard silicone optic IOLs, 98.2% +/- 3.1%. CONCLUSIONS: Intraocular lenses with a hydrophilic optic have less tendency toward adherence to silicone oil than more hydrophobic designs. A foldable silicone IOL with heparin surface modification can significantly reduce potential silicone oil adherence, comparable to the level achievable with the rigid HSM PMMA designs. Two new foldable IOL styles, the HSM silicone IOL and IOLs in the general class of hydrophilic-acrylic, were highly efficacious in reducing silicone oil adherence. There is now a real choice of foldable lenses for patients with actual or potential vitreoretinal diseases.