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1.
Emerg Infect Dis ; 25(1): 132-135, 2019 01.
Article in English | MEDLINE | ID: mdl-30561299

ABSTRACT

In the Brazilian Amazon, the suspected source of infection in an outbreak of acute Chagas disease involving 10 patients was Euterpe oleracea (açaí berry) juice. Patient blood and juice samples contained Trypanosoma cruzi TcIV, indicating oral transmission of the Chagas disease agent.


Subject(s)
Chagas Disease/transmission , Disease Outbreaks , Euterpe , Fruit and Vegetable Juices/parasitology , Trypanosoma cruzi/physiology , Adolescent , Adult , Aged , Brazil/epidemiology , Chagas Disease/parasitology , Female , Food Safety , Humans , Infant , Male , Middle Aged , Young Adult
2.
J Infect Dev Ctries ; 7(3): 243-52, 2013 Mar 14.
Article in English | MEDLINE | ID: mdl-23493003

ABSTRACT

INTRODUCTION: In remote areas of the Amazon Region, diagnosis of malaria by microscopy is practically impossible. This study aimed to evaluate the performance of two rapid diagnostic tests (RDTs) targeting different malaria antigens stored at room temperature in the Brazilian Amazon Region. METHODOLOGY: Performance of the OptiMal Pf/Pan test and ICT-Now Pf/Pan test was analyzed retrospectively in 1,627 and 1,602 blood samples, respectively. Tests were performed over a 15-month period. Kits were stored at room temperature in five community health centres located in the Brazilian Amazon Region. RDT results were compared with thick blood smear (TBS) results to determine sensitivity, specificity, and accuracy of the RDT. RESULTS: The sensitivities of the OptiMal Pf/Pan test were 79.7% for Plasmodium falciparum malaria diagnosis and 85.7% for non-P. falciparum infections. The results showed a crude agreement of 88.5% for P. falciparum, and 88.3% for non-P. falciparum infections (Kappa index = 0.74 and 0.75, respectively). For the ICT-Now Pf/Pan test (CI 95%), the sensitivities were 87.9% for P. falciparum malaria diagnosis and 72.5% for non-P. falciparum infection. Crude agreement between the ICT-Now Pf/Pan test and TBS was 91.4% for P. falciparum and 79.7% for non-P. falciparum infection. The Kappa index was 0.81 and 0.59 for the final diagnosis of P. falciparum and non-P. falciparum, respectively. Higher levels of parasitaemia were associated with higher crude agreement between RDT and TBS. CONCLUSIONS: The sensitivities of RDTs stored at room temperature over a 15-month period and performed in field conditions were lower than those previously reported.


Subject(s)
Antigens, Protozoan/blood , Diagnostic Tests, Routine/methods , Malaria, Falciparum/diagnosis , Plasmodium falciparum/isolation & purification , Specimen Handling/methods , Adolescent , Adult , Aged , Brazil , Child , Child, Preschool , Female , Humans , Immunoassay/methods , Infant , Male , Middle Aged , Plasmodium falciparum/immunology , Sensitivity and Specificity , Temperature , Time Factors , Young Adult
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