Subject(s)
Exanthema , Psoriasis , Child , Humans , Peroxidase , Psoriasis/genetics , Mutation , Chronic DiseaseSubject(s)
Antineoplastic Agents , Carcinoma, Basal Cell , Skin Neoplasms , Humans , Carcinoma, Basal Cell/drug therapy , Carcinoma, Basal Cell/pathology , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Anilides/therapeutic use , Pyridines/therapeutic use , Antineoplastic Agents/therapeutic useABSTRACT
INTRODUCTION: Sensitization to cat and dog allergens is common in patients with allergic respiratory diseases. The study objective was to determine the prevalence of immunoglobulin E (IgE) sensitization to specific cat and dog allergens using component-resolved diagnosis (CRD) in patients with allergic respiratory diseases plus cat and/or dog sensitization. METHODS: We included 87 patients aged 8-62 years, diagnosed with allergic asthma and/or rhinitis plus cat and/or dog sensitization, and attended at the allergy section of a tertiary hospital in Badalona (Catalonia, Spain). We used CRD to determine IgE sensitization to specific cat/dog allergens and skin prick tests (SPTs) to determine differences between diagnostic test results. RESULTS: Patients were monosensitized to cats (20.7%) or dogs (3.4%) or sensitized to both (75.9%). The highest positive allergen rates were for Fel d 1 (91.7%) and Fel d 4 (41%) in patients sensitized to cat allergens and for Can f 5 (80%) and Can f 1 (70%) in those sensitized to dog allergens. CRD and SPT results differed somewhat: 16.1% and 27.6% of patients CRD positive for cat or dog sensitization, respectively, were SPT negative, and 6.9% SPT positive for dog sensitization were CRD negative. Few statistically significant relationships were found between any allergen components and any respiratory disease characteristic or contact with furry animals. CONCLUSIONS: CRD may be used to determine the prevalence of IgE sensitization to specific cat and dog allergens in patients with allergic respiratory diseases plus cat and/or dog sensitization. As SPT may not correctly identify all patients sensitized to cats and dogs, our results support the use of CRD.
Subject(s)
Asthma , Hypersensitivity , Dogs , Cats , Animals , Allergens , Spain/epidemiology , Hypersensitivity/diagnosis , Hypersensitivity/epidemiology , Asthma/diagnosis , Asthma/epidemiology , Immunoglobulin E , Skin TestsSubject(s)
Melanoma , Melanosis , Skin Neoplasms , Humans , Melanoma/pathology , Melanosis/complications , Nivolumab/adverse effects , Skin Neoplasms/pathologySubject(s)
Brain Ischemia/complications , Stroke , Skin Ulcer/etiology , Stroke/complications , Trigeminal NerveSubject(s)
Brain Ischemia , Ischemic Stroke , Skin Ulcer , Stroke , Brain Ischemia/complications , Humans , Skin Ulcer/etiology , Stroke/complicationsABSTRACT
A 14-year-old girl who reported generalized scaling and hyperkeratosis since age 1 year presented with severe pruritus of several months' duration. Scabies mites were detected, and molecular genetic analysis subsequently revealed a rare pathogenic variant in the keratin 2 (KRT2) gene, confirming a diagnosis of superficial epidermolytic ichthyosis. Treatment with oral ivermectin led to complete remission of symptoms. Disorders of keratinization can mimic clinical signs of scabies, leading to a delay in diagnosis.