ABSTRACT
SARS CoV-2 virus has infected more than 200 million people worldwide and more than 4.4 million in Indonesia. The vaccination program has become one of the solutions launched by many countries globally, including Indonesia, to reduce the transmission rate of COVID-19. Various vaccination platforms are produced, such as inactivated, viral vector, mRNA, and protein subunit. The vaccination booster program with mRNA platform (Moderna) was launched by the Indonesian government to give better protection for health care workers, particularly from delta variant. In this case report, we discuss one of the typical side effects of Moderna vaccine, which is referred to as the COVID arm.
Subject(s)
Acetaminophen/administration & dosage , COVID-19 Vaccines , COVID-19/prevention & control , Drug-Related Side Effects and Adverse Reactions , Hypersensitivity, Delayed , Skin/pathology , 2019-nCoV Vaccine mRNA-1273 , Analgesics, Non-Narcotic/administration & dosage , Biopsy/methods , COVID-19/epidemiology , COVID-19 Vaccines/administration & dosage , COVID-19 Vaccines/adverse effects , Drug-Related Side Effects and Adverse Reactions/etiology , Drug-Related Side Effects and Adverse Reactions/physiopathology , Drug-Related Side Effects and Adverse Reactions/therapy , Female , Fever/drug therapy , Fever/etiology , Humans , Hypersensitivity, Delayed/chemically induced , Hypersensitivity, Delayed/physiopathology , Hypersensitivity, Delayed/therapy , Injection Site Reaction/diagnosis , Injection Site Reaction/etiology , Injection Site Reaction/physiopathology , Middle Aged , Physicians , SARS-CoV-2 , Treatment Outcome , Vaccination/methodsABSTRACT
Nail involvement in Langerhans cell histiocytosis (LCH) is very uncommon. We describe a 9-month-old boy with longitudinal purpuric bands, onychodystrophy, and paronychias on his fingernails and toenails, which antedated manifestations of recurrent bilateral spontaneous pneumothorax and elevated transaminases. The diagnosis of nail LCH was then confirmed by immunohistochemistry demonstrating positive S100 and CD1a staining in the epithelium of nail bed tissue. This case report affirms that nail involvement may be the initial manifestation of multisystem LCH and could portend an unfavorable prognosis.
