Synthesis of strontium oxide-zinc oxide nanocomposites by Co-precipitation method and its application for degradation of malachite green dye under direct sunlight.

Photocatalysts workable under direct sunlight are the safe and cost-effective option for water purification. The nanocomposites of strontium oxide and zinc oxide (SZ NCs) were synthesized using coprecipitation method. The respective precursors of SZ NCs were subjected to alkaline hydrolysis and subsequently thermally treated to yield SZ NCs. The SZ NCs with different ZnO composition was synthesized by varying the concentration of ZnO precursor from 0.2 to 1 M. The structural properties of SZ NCs evaluated using X-Ray diffraction (XRD), Thermogravimetric analysis (TGA), and Differential thermal analysis DTA). The optical properties of SZ NCs studied using ultraviolet-visible (UV-Vis) spectroscopic study. The trend observed in the intensity of XRD peaks indicated the occurrence of Zn doping in the crystalline lattice of SrO and the formation of SrO-ZnO composite. Upon incorporation of 1 M of ZnO precursor, the grain size of the SrO was decreased from 49.3 to 27.6 nm. The weight loss in the thermal analysis indicates the removal of carbonates from the sample upon heating and shows the formation of an oxide structure. UV-Vis spectra confirmed that the presence of SrO enhanced the sunlight absorption of SZ NCs. The increase in the composition of ZnO precursors increased the bandgap of SrO (2.09 eV) to the level of ZnO (3.14 eV). SZ NCs exhibited heterostructure morphology, where the nanosized domains with varying shapes (layered and rod-like) were observed. Under direct sunlight conditions, SZ NCs prepared using 1 M/0.6 M of SrO/ZnO precursors exhibited 15-20 % higher photocatalytic efficiency than neat SrO and ZnO. In precise, 1 mg of this SZ NC was degraded 98 % of malachite green dye dissolved in water (10 ppm) under direct sunlight. Additionally, the thermal stability results showed that 18 % decomposition was obtained due to the degradation impurities in SrO/ZnO catalysts and the XRD results revealed that no structural change is obtained in SrO/ZnO photocatalysts after stability test. The SZ NCs can be effectively used as safe and economic sunlight photocatalysts for water purification in remote areas without the electricity.

Phytochemical Analysis and Antioxidant Activity of Centella Asiatica Extracts: An Experimental and Theoretical Investigation of Flavonoids.

Centella asiatica (CA) is a medicinal plant widely used in the East, with many of its phytoconstituents remaining unexplored. In this study, compounds were extracted and identified from C. asiatica to determine its medicinal properties. Phytochemical screening was conducted on shoot, callus, and cell suspension extracts, revealing the presence of tannins, flavonoids, terpenoids, saponins, and steroids in all three cultures, with no alkaloids detected. IC50 values were determined to evaluate the antioxidant activity of the extracts, with the highest value observed for cell suspension culture (20 µg/mL), followed by shoot culture (19 µg/mL), and then callus extract (10 µg/mL), with ascorbic acid as the standard at an IC50 value of 26.25 µg/mL. Finally, density functional theory was used to analyze the structure-activity relationships of the identified compounds from C. asiatica extract. The results suggest that ultrasonic-assisted extraction yielded the highest recovery and antioxidant activity, with a scavenging activity of 79%. This study provides valuable insights into the phytochemical composition and antioxidant potential of C. asiatica, which may have implications for its use in traditional medicine and future drug development.

Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering.

Selective laser sintering (SLS) is an additive manufacturing process that has shown promise in the production of medical devices, including hip cups, knee trays, dental crowns, and hearing aids. SLS-based 3D-printed dosage forms have the potential to revolutionise the production of personalised drugs. The ability to manipulate the porosity of printed materials is a particularly exciting aspect of SLS. Porous tablet formulations produced by SLS can disintegrate orally within seconds, which is challenging to achieve with traditional methods. SLS also enables the creation of amorphous solid dispersions in a single step, rather than the multi-step process required with conventional methods. This review provides an overview of 3D printing, describes the operating mechanism and necessary materials for SLS, and highlights recent advances in SLS for biomedical and pharmaceutical applications. Furthermore, an in-depth comparison and contrast of various 3D printing technologies for their effectiveness in tissue engineering applications is also presented in this review.

Synthesis of Solar Light Active Reduced Graphene Oxide-ZnS Nanomaterial for Photocatalytic Degradation and Antibacterial Applications.

Good water quality is essential for life; therefore, decolorizing and detoxifying organic dye wastes (textile effluents) have gained immense environmental importance in recent years. Thus, the degradation of wastewater has become a potential need for our environment. This research aims to synthesize and investigate a ceramic-based nanomaterial catalyst for the degradation of dye solution under exposure to sunlight. A reduced graphene oxide-ZnS (rGO-ZnS) nanomaterial was qualitatively synthesized using a solvothermal method. The prepared nanomaterial was characterized using XRD, SEM, HR-TEM, EDX, XPS, and FT-IR techniques. The photocatalytic activity of the rGO-ZnS nanomaterial was checked using oxidative photocatalytic degradation of naphthol blue black dye (NBB) under direct sunlight irradiation. Here, the rGO/ZnS composite showed a significant photocatalytic performance to degraded NBB (93.7%) under direct solar light. Chemical Oxygen Demand (COD) measurements confirmed the mineralization of the dye. The influence of different radical scavengers on NBB degradation was studied. Optimum conditions for efficient degradation were determined. The antibacterial property of the prepared catalyst was studied.

Gel Polymer Electrolytes: Advancing Solid-State Batteries for High-Performance Applications.

Gel polymer electrolytes (GPEs) hold tremendous potential for advancing high-energy-density and safe rechargeable solid-state batteries, making them a transformative technology for advancing electric vehicles. GPEs offer high ionic conductivity and mechanical stability, enabling their use in quasi-solid-state batteries that combine solid-state interfaces with liquid-like behavior. Various GPEs based on different materials, including flame-retardant GPEs, dendrite-free polymer gel electrolytes, hybrid solid-state batteries, and 3D printable GPEs, have been developed. Significant efforts have also been directed toward improving the interface between GPEs and electrodes. The integration of gel-based electrolytes into solid-state electrochemical devices has the potential to revolutionize energy storage solutions by offering improved efficiency and reliability. These advancements find applications across diverse industries, particularly in electric vehicles and renewable energy. This review comprehensively discusses the potential of GPEs as solid-state electrolytes for diverse battery systems, such as lithium-ion batteries (LiBs), lithium metal batteries (LMBs), lithium-oxygen batteries, lithium-sulfur batteries, zinc-based batteries, sodium-ion batteries, and dual-ion batteries. This review highlights the materials being explored for GPE development, including polymers, inorganic compounds, and ionic liquids. Furthermore, it underscores the transformative impact of GPEs on solid-state batteries and their role in enhancing the performance and safety of energy storage devices.

One-Pot Hydrothermal Preparation of Hydroxyapatite/Zinc Oxide Nanorod Nanocomposites and Their Cytotoxicity Evaluation against MG-63 Osteoblast-like Cells.

In the present study, HAp-ZnO nanorod nanocomposites were successfully prepared using a customized hydrothermal reactor and studied for their compatibility against MG-63 osteoblast-like cells. The crystallinity, morphology, presence of chemical elements, and surface area properties were studied by XRD (X-ray diffraction), FE-SEM (field emission scanning electron microscopy), TEM (transmission electron microscopy), EDS (energy dispersive spectrum) and N2 adsorption/desorption isotherm techniques, respectively. Further, the mechanical strength and thermal analysis were carried out using the nanoindentation method and thermogravimetric/differential scanning calorimeter (TG/DSC) methods, respectively. Moreover, in vitro biocompatibility studies for the prepared samples were carried out against human osteosarcoma cell lines (MG-63). The crystalline nature of the samples without any impurity phases was notified from XRD results. The formation of composites with the morphology of nanorods and the presence of desired elements in the intended ratio were verified using FE-SEM and EDS spectra, respectively. The TG/DSC results revealed the improved thermal stability of the HAp matrix, promoted by the reinforcement of the ZnO nanorods. The nanoindentation study ensured a significant enhancement in the mechanical stability of the prepared composite material. Finally, it demonstrated that the HAp matrix's mechanical strength and thermal stability were improved by the reinforcement of ZnO, and the cytotoxicity evaluation affirmed the biocompatible nature of the biomimetic hydroxyapatite in the composite.

Preparation and Characterization of Salsalate-Loaded Chitosan Nanoparticles: In Vitro Release and Antibacterial and Antibiofilm Activity.

The controlled-release characteristic of drug delivery systems is utilized to increase the residence time of therapeutic agents in the human body. This study aimed to formulate and characterize salsalate (SSL)-loaded chitosan nanoparticles (CSNPs) prepared using the ionic gelation method and to assess their in vitro release and antibacterial and antibiofilm activities. The optimized CSNPs and CSNP-SSL formulation were characterized for particle size (156.4 ± 12.7 nm and 132.8 ± 17.4 nm), polydispersity index (0.489 ± 0.011 and 0.236 ± 132 0.021), zeta potential (68 ± 16 mV and 37 ± 11 mV), and entrapment efficiency (68.9 ± 2.14%). Physicochemical features of these nanoparticles were characterized using UV-visible and Fourier transform infrared spectroscopy and X-ray diffraction pattern. Scanning electron microscopy studies indicated that CSNPs and CSNP-SSL were spherical in shape with a smooth surface and their particle size ranged between 200 and 500 nm. In vitro release profiles of the optimized formulations showed an initial burst followed by slow and sustained drug release after 18 h (64.2 ± 3.2%) and 48 h (84.6 ± 4.23%), respectively. Additionally, the CSNPs and CSNP-SSL nanoparticles showed a sustained antibacterial action against Staphylococcus aureus (15.7 ± 0.1 and 19.1 ± 1.2 mm) and Escherichia coli (17.5 ± 0.8 and 21.6 ± 1.7 243 mm). Interestingly, CSNP-SSL showed better capability (89.4 ± 1.2% and 95.8 ± 0.7%) than did CSNPs in inhibiting antibiofilm production by Enterobacter tabaci (E2) and Klebsiella quasipneumoniae (SC3). Therefore, CSNPs are a promising dosage form for sustained drug delivery and enhanced antibacterial and antibiofilm activity of SSL; these results could be translated into increased patient compliance.

Structural Activity and HAD Inhibition Efficiency of Pelargonidin and Its Glucoside-A Theoretical Approach.

Anthocyanins are an important pharmaceutical ingredient possessing diet regulatory, antioxidant, anticancer, antidiabetic, anti-obesity, antimicrobial, and anti-inflammatory properties. Pelargonidin is an important anthocyanin-based orange-red flavonoid compound used in drugs for treating hypoglycemia, retinopathy, skeletal myopathy, etc. The main sources of pelargonidin are strawberries and food products with red pigmentation. There is a lack of evidence for supporting its use as an independent supplement. In the present study, pelargonidin and pelargonidin-3-O-glucoside are studied for their structural properties using quantum chemical calculations based on density functional theory. The results confirmed that the parent compound and its glycosylated derivative acted as good electron donors. Electrostatic potential, frontier molecular orbitals, and molecular descriptor analyses also substantiated their electron donating properties. Furthermore, based on the probability, a target prediction was performed for pelargonidin and pelargonidin-3-O-glucoside. Hydroxyacyl-coenzyme A dehydrogenase was chosen as an enzymatic target of interest, since the presence work focuses on glucuronidated compounds and their efficacy over diabetes. Possible interactions between these compounds and a target with nominable binding energies were also evaluated. Further, the structural stability of these two compounds were also analyzed using a molecular dynamics simulation.

Sorption based easy-to-use low-cost filters derived from invasive weed biomass for dye contaminated water cleanup.

Today, the development of functional nanostructured materials with specified morphologies utilizing environmentally friendly techniques is a very appealing topic in materials chemistry. Much emphasis has recently been paid to the utilization of biomass to make functional carbonaceous materials of varying forms, specifically carbon helices, with greater implications for the environment, economy, and society. A metal-catalyzed chemical vapour deposition technique has been developed for the fabrication of such carbon helices from nonrenewable hydrocarbons. Also, functionalization approaches were seen to necessitate high temperatures, hazardous gases, and multi-step processes. Herein, we have synthesized tendril-like functional carbon helices (HTCs) from toxic bio-weed, Parthenium hysterophorus as the carbon source by a greener solvothermal method employing deep eutectic solvent (DES) as both soft template and catalyst. Further, for the first time by taking advantage of the in-built chemical functionalities, HTCs were physically activated in an inert atmosphere at 900 °C (AHC) and functionalized with manganese oxide at room temperature by employing DES. Furthermore, the materials were characterized using FE-SEM, EDX, FT-IR, XRD, and BET analysis, where a surface area of 313.12 m2 g-1 was achieved with a robust removal of 99.68% of methylene blue (MB) dye with a flux rate of 7432.71 LMH in a simulated continuous flow system. The obtained material was also evaluated for its specificity towards contaminant removal from an aqueous medium. Thus, Mn3O4/AHC membranes exhibited great promise as an easy-to-use filter for organic contaminant cleanup, with about 91% rejection of MB even at the end of the 10th cycle, indicating its potential.

Restructuring thin film composite membrane interfaces using biopolymer as a sustainable alternative to prevent organic fouling.

Replacing polyamide (PA) layer in commercially successful thin film composite (TFC) membranes prepared via interfacial polymerization has been challenging task. Lately, PA is under scrutiny due to its increasing fouling propensity for highly contaminated waters. To mitigate the bio and organic fouling on PA layer in nanofiltration (NF) membranes in a long run, present study attempts to create a new interfacial thin film asymmetric structure using biopolymer chitosan as sustainable alternative. Herein, the effect of chitosan-silver on porous support structure and filtration performance were systematically investigated. Further, the membranes were characterized for their functionality and surface characteristics using ATR-IR, FESEM, AFM, UV-vis spectroscopy and contact angle measurements, respectively. New asymmetric membrane performances in cross flow process were evaluated in terms of pure water flux, NaCl (∼40 %), red brown/organic dye (>98 %) and tannery wastewater flux and rejection (>98 %). With a higher pure water flux (>100 L m-2 h-1) compared to control (40 L m-2 h-1) at 4 bar, membrane showed exceptional antifouling behaviors in comparison to commercial PA membrane. Further, surface characteristics of the membranes before and after rigorous testing were evaluated using AFM micrographs and SEM imaging.

Biomass-derived carbon helices induced phase transition in poly(N-ispropylacrylamide): A sustainable tailoring of coil-globule transition in thermoresponsive polymer.

Functional carbon helices (FCHs) containing various oxygenated functionalities derived directly from lignocellulosic biomass is proved to be a potential eco friendly candidate for biomolecules. No study reports the effect of biomass derived platform molecules on the thermoresponsive behavior of polymers, which have been proved potential candidates in carrying various drug delivery applications, gels, and tissue engineering in this vast area of research. Poly(N-isopropylacrylamide) (PNIPAM) is a thermoresponsive polymer that has been found to be a prevailing tool in carrying various aforesaid applications. This study reports a powerful impact on the thermoresponsive behavior of PNIPAM by a non-hazardous alternative form of a herbecious plant Parthenium hysterophorus. Fluorescence spectroscopy was deployed to study the microenvironment provided by carbon helices around the polymer structure. The results obtained are directly correlating with the increased polarity with higher concentration of FCHs and further confirmed a decrease in fluorescence intensity. Moreover, for better understanding of interactions between PNIPAM and FCHs, Fourier transform infrared spectroscopy (FTIR) was employed. The analysis of hydrodynamic diameter (dH) was carried out by dynamic light scattering (DLS) and the aggregate size of PNIPAM was found to increase in higher concentration of FCHs. A decrease from 34.7 °C to 29.0 °C in the lower critical solution temperature (LCST) of PNIPAM in FCHs was further confirmed by differential scanning calorimetry (DSC). Field emission scanning electron microscopy (FESEM) and Transmission electron microscopy (TEM) were also taken into account to understand the morphological changes of PNIPAM in presence of biomass derived carbon helices. The micrographs of PNIPAM-biomass are representing a perturbed morphology of PNIPAM during interaction with FCHs. In this study, high degree of oxygenated functionalities on the carbon helices has a meaningful impact on the conformational phase behavior of PNIPAM. The tendril like functional carbon helices (TLFCHs) are uniquely causing a decrease in the lower critical solution temperature (LCST) of PNIPAM. Our combined study indicates that biomass derived carbon helices significantly decrease the LCST of PNIPAM by 5 °C. Ultimately, the polymer achieves compact globule conformational and complete aggregated state.