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Magn Reson Imaging ; 51: 69-78, 2018 09.
Article in English | MEDLINE | ID: mdl-29704561

ABSTRACT

PURPOSE: In this study, we aimed to determine the usefulness of diffusion kurtosis imaging (DKI) as a noninvasive method for evaluation of the histologic grade and lymph node metastasis in patients with oral carcinoma. MATERIALS AND METHODS: Twenty-seven patients with oral carcinoma were examined with a 3-T MR system and 16-channel coil. DKI data were obtained by a single-shot echo-planar imaging sequence with repetition time, 10,000 ms; echo time, 94 ms; field of view, 250 × 204.25 ms; matrix, 120 × 98; section thickness, 4 mm; four b values of 0, 500, 1000, and 2000 s/mm2; and motion-probing gradients in three orthogonal directions. Diffusivity (D) and kurtosis (K) were calculated using the equation: S = S0 ∙ exp(-b ∙ D + b2 ∙ D2 ∙ K/6). Conventional apparent diffusion coefficient (ADC) was also calculated. The MR images were compared with the histopathologic findings. RESULTS: Relative to the histologic grades (Grades 1, 2, and 3) of the 27 oral carcinomas, D values showed a significant inverse correlation (r = -0.885; P < 0.001) and K values showed a significant positive correlation (r = 0.869; P < 0.001), whereas ADC values showed no significant correlation (r = -0.311; P = 0.115). When comparing between metastatic and non-metastatic lymph nodes, significant differences in the D values (P < 0.001) and K values (P < 0.001), but not the ADC values (P = 0.110) became apparent. CONCLUSIONS: In patients with oral carcinoma, DKI seems to be clinically useful for the evaluation of histologic grades and lymph node metastasis.


Subject(s)
Carcinoma, Squamous Cell/diagnostic imaging , Diffusion Magnetic Resonance Imaging/methods , Image Interpretation, Computer-Assisted/methods , Mouth Neoplasms/diagnostic imaging , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/pathology , Correlation of Data , Echo-Planar Imaging/methods , Female , Gingival Neoplasms/diagnostic imaging , Gingival Neoplasms/pathology , Humans , Lymph Nodes/diagnostic imaging , Lymphatic Metastasis/diagnostic imaging , Lymphatic Metastasis/pathology , Male , Middle Aged , Mouth Floor/diagnostic imaging , Mouth Floor/pathology , Mouth Neoplasms/pathology , Neoplasm Grading , Tongue/diagnostic imaging , Tongue/pathology , Tongue Neoplasms/diagnostic imaging , Tongue Neoplasms/pathology
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