ABSTRACT
Cell suspension consisting of cells from immature nervous and hemopoietic tissues was transplanted subarachnoidally to patients with craniocerebral injury aftereffects. In some patients cell therapy led to immune sensitization to donor antigens, detected by the leukocyte migration inhibition test. No signs of tissue-destructive autoimmune reactions were detected in patients receiving cell therapy. Follow-up of 56 patients showed that cell therapy was associated with significant improvement of the neurological status. No serious complications of this treatment modality were observed. Presumably, cell therapy is a safe method which can be used in the treatment of craniocerebral injury aftereffects.
Subject(s)
Craniocerebral Trauma/immunology , Craniocerebral Trauma/therapy , Hematopoietic Stem Cell Transplantation , Neurons/transplantation , Adolescent , Adult , Aged , Cell Migration Inhibition , Fetal Tissue Transplantation , Humans , Middle Aged , Tissue Transplantation , Treatment OutcomeABSTRACT
We demonstrated that liquor from adult humans can maintain proliferative activity of cells of immature nervous tissue in vitro. The paper presents the results of a retrospective clinical study of the efficiency of cell therapy in the treatment of II-III degree comatose patients with severe brain injury. Cell suspension consisting of cells derived from immature nervous and hemopoietic tissues was injected into the recipient subarachnoidal space through a cerebrospinal puncture. The mortality in the study group was 8% vs. 56% in the control group. The 1.5-year follow-up demonstrated significantly better quality of life in patients receiving cell therapy in comparison with patients of the control group. Cell therapy proved to be ineffective for patients in a comatose state caused by hypoxic encephalopathy. The study demonstrated the efficiency of cell therapy in patients with severe brain injury during the acute period of the disease.
Subject(s)
Cell- and Tissue-Based Therapy/methods , Coma, Post-Head Injury/therapy , Diffuse Axonal Injury/pathology , Fetal Tissue Transplantation/methods , Hematopoietic Stem Cell Transplantation/methods , Hypoxia, Brain/therapy , Neurons/transplantation , Adult , Case-Control Studies , Cell Extracts/pharmacology , Cell Proliferation/drug effects , Electroencephalography , Evaluation Studies as Topic , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Subarachnoid Space , Treatment Outcome , Ultrasonography, DopplerABSTRACT
Cell suspension consisting of cells from immature nervous and hemopoietic tissues was subarachnoidally transplanted to 10 patients with brain stroke consequences. Clinical effect of different degree was attained in all patients. Six months after cell therapy functional activity significantly increased in contrast to clinically comparable control group. No serious complications of cell therapy were observed. Presumably, cell therapy is a more or less safe method of treatment, which can be effectively used in the treatment of brain stroke consequences.
