Respiratory Function of Mitochondria in Patients with Coronary Heart Disease with Implantable Cardioverter-Defibrillator.

We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history of ventricular tachyarrhythmias required cardioverter-defibrillator implantation. The measurements were carried out in incubation buffers with different oxidation substrates (succinate and pyruvate-malate mixture). In pyruvate-malate incubation buffer, oxygen consumption rate and respiratory control coefficients in patients with triggered device did not differ significantly from those in patients without cardioverter-defibrillator triggering. At the same time, respiratory control coefficients were below the reference values. In succinate buffer, values of mitochondrial parameters were significantly lower in patients with triggered devices. Our findings indicate that mitochondria of patients with non-triggered cardioverters-defibrillators have better functional and metabolic plasticity. It was concluded that activity of respiratory processes in mitochondria could be an indicator that should be taken into the account when assessing the risk of developing ventricular tachyarrhythmias.

[Effect of coamide on the morpho-functional state of the pancreatic islands in irradiated animals]. / Vliianie koamida na morfo-funktsional'noe sostoianie pankreaticheskikh ostrovkov u obluchennykh zhivotnykh.

X-Irradiation of animals with a dose of 6 Gy brings about fatty degeneration of the liver and a concurrent destruction of the morphological status in functional activity of the insular apparatus. The administration of coamide promotes the recovery of the morphological and physiological status of the pancreas.