ABSTRACT
OBJECTIVE: To design a new method for oral preparation of urine for sperm retrieval after retrograde ejaculation (RE) and to test the motility of sperm exposed to prepared and unprepared urine. DESIGN: In vitro testing of urine conditions and sperm motility. SETTING: Assisted conception unit at a teaching hospital in the United Kingdom. PATIENT(S): Ten healthy volunteers to provide urine and sperm specimens from men attending the unit for semen analysis. INTERVENTION(S): Various solutions of sodium bicarbonate and sodium chloride were drunk by a single subject until a suitable regimen was achieved. This regimen (called the Liverpool solution) was then tested on 10 volunteers. Samples of sperm were then added to prepared urine, unprepared urine, and culture medium, and the motility was analyzed. MAIN OUTCOME MEASURE(S): Urinary pH and osmolarity, sperm motility. RESULT(S): Urine produced by the 10 volunteers had a mean pH of 7.47 (range, 7.23-7.79) and a mean osmolarity of 289 mOsmol/L (range, 225-412 mOsmol/L), similar to that of medium. The progressive motility of sperm exposed to the unprepared urine was reduced (42.4% of sperm in medium), whereas that in the prepared urine was similar to that in the control medium. CONCLUSION(S): Liverpool solution can be used in any unit treating couples with RE, and it is a noninvasive and inexpensive regimen that may optimize urine pH and osmolarity for sperm survival after RE.
Subject(s)
Drinking , Ejaculation , Infertility, Male/therapy , Sodium Bicarbonate/administration & dosage , Sodium Chloride/administration & dosage , Sperm Motility , Spermatozoa , Administration, Oral , Culture Media/chemistry , Humans , Hydrogen-Ion Concentration , Infertility, Male/physiopathology , Infertility, Male/urine , Male , Osmolar Concentration , Sodium Bicarbonate/urine , Sodium Chloride/urine , Time Factors , Urine/chemistry , Urine/cytologyABSTRACT
We report a case of tubercular prostatic abscess in a patient who had undergone intravesical bacillus Calmette-Guérin immunotherapy for bladder carcinoma in situ. The abscess required surgical drainage and antituberculous treatment.
Subject(s)
Abscess/chemically induced , BCG Vaccine/adverse effects , Carcinoma, Transitional Cell/therapy , Immunotherapy/adverse effects , Prostatitis/chemically induced , Tuberculosis, Male Genital/chemically induced , Urinary Bladder Neoplasms/therapy , Abscess/microbiology , Abscess/surgery , Adjuvants, Immunologic/administration & dosage , Adjuvants, Immunologic/adverse effects , Administration, Intravesical , BCG Vaccine/administration & dosage , Carcinoma, Transitional Cell/pathology , Humans , Male , Middle Aged , Mycobacterium bovis/isolation & purification , Prostatectomy , Prostatitis/microbiology , Prostatitis/surgery , Tuberculosis, Male Genital/microbiology , Tuberculosis, Male Genital/surgery , Urinary Bladder Neoplasms/pathologyABSTRACT
OBJECTIVE: To describe the use of a Malecot catheter as a stent after radical trachelectomy (RT). DESIGN: Case report. SETTING: Assisted conception unit at a teaching hospital in the United Kingdom. PATIENT(S): A 36-year-old woman undergoing IVF after her cervix had been excised for cervical carcinoma. Previous attempts at embryo transfer (ET) had been very traumatic and required a transmyometrial transfer on one occasion. INTERVENTION(S): A Malecot catheter was inserted into the uterine cavity after a dilatation procedure had been performed and removed before ovarian stimulation. MAIN OUTCOME MEASURE(S): Ease of ET. RESULT(S): The subsequent ET was much more straightforward. CONCLUSION(S): This technique can facilitate ET after RT if the passage is found to be stenosed.
Subject(s)
Catheters, Indwelling , Embryo Transfer/instrumentation , Gynecologic Surgical Procedures/instrumentation , Adult , Female , Gynecologic Surgical Procedures/methods , HumansABSTRACT
Incompetence of the internal urethral sphincter causes semen to pass into the bladder. Infertility can be successfully treated by restoring normal ejaculation or by sperm retrieval techniques.
Subject(s)
Ejaculation , Infertility, Male/etiology , Urethral Diseases/complications , Humans , Hydrogen-Ion Concentration , Infertility, Male/diagnosis , Infertility, Male/therapy , Male , Urethral Diseases/diagnosis , Urethral Diseases/therapy , Urine/chemistryABSTRACT
OBJECTIVE: To describe a potential new use of gonadotropin-releasing hormone (GnRH) antagonists. DESIGN: Case report. SETTING: Assisted conception unit at a teaching hospital in the United Kingdom. PATIENT(S): A 37-year-old woman undergoing in vitro fertilization (IVF) who accidentally stopped using GnRH agonists after starting ovarian stimulation. INTERVENTION(S): A GnRH antagonist was used to avoid a luteinizing hormone (LH) surge and hence "rescue" the cycle. RESULT(S): Successful oocyte retrieval was carried out, two embryos transferred, and a viable twin pregnancy ensued. CONCLUSION(S): This may be a new indication for the use of GnRH antagonists.
Subject(s)
Buserelin/administration & dosage , Fertilization in Vitro , Gonadotropin-Releasing Hormone/antagonists & inhibitors , Accidents , Adult , Embryo Transfer , Female , Gonadotropin-Releasing Hormone/agonists , Humans , Luteinizing Hormone/antagonists & inhibitors , Male , Oocytes , Patient Compliance , Pregnancy , Pregnancy, Multiple , Sperm Injections, Intracytoplasmic , Tissue and Organ Harvesting , TwinsABSTRACT
This report describes an asymptomatic perforation with the GyneFix intrauterine contraceptive implant. A review of all other reports of this complication has been performed. Analysis of these reports suggests prolonged amenorrhoea secondary to continuous progestogen use as a possible common predisposing factor.
