ABSTRACT
This case report details the management of a 10-year-old female pediatric patient with Harlequin ichthyosis (HI), a challenging skin disorder characterized by the production of 40 times the normal skin without trifats, leading to recurrent splits and fissures. Conventional treatments were ineffective until the introduction of nanobubbles. Encouraged by successful cases, the family engaged in a 100-hour medical trial conducted three days a week at the dermatologist's office, witnessing positive outcomes after the initial 20-minute session. The nanobubble's success inspired the creation of the White Water Company in 2016, developing the first portable nanobubbler. Nanobubble technology not only addressed excessive skin production but also played a crucial role in biofilm remediation, offering a solution to an additional challenge. The 100-hour medical trial demonstrated commitment to the patient's well-being. The nanobubble bath completed the scratch-itch cycle by shedding skin during the bath and moisturizing the skin from the inside out, providing a holistic solution to the challenges posed by HI.