1.
Org Biomol Chem
; 15(34): 7227-7234, 2017 Aug 30.
Article
in English
| MEDLINE
| ID: mdl-28816328
ABSTRACT
Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate.
Subject(s)
Alkenes/chemistry , Nucleosides/chemistry , Organophosphonates/chemistry , Organophosphonates/chemical synthesis , Palladium/chemistry , Amination , Catalysis , Chemistry Techniques, Synthetic
2.
J Org Chem
; 81(12): 5217-21, 2016 06 17.
Article
in English
| MEDLINE
| ID: mdl-27182738
ABSTRACT
A formal enantioselective synthesis of nectrisine, a potent α-glucosidase inhibitor, was carried out starting from butadiene monoepoxide through a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, dihydroxylation, and cyclization.