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Nat Commun ; 12(1): 4841, 2021 08 17.
Article in English | MEDLINE | ID: mdl-34404770

ABSTRACT

RAS proteins are GTPases that lie upstream of a signaling network impacting cell fate determination. How cells integrate RAS activity to balance proliferation and cellular senescence is still incompletely characterized. Here, we identify ZNF768 as a phosphoprotein destabilized upon RAS activation. We report that ZNF768 depletion impairs proliferation and induces senescence by modulating the expression of key cell cycle effectors and established p53 targets. ZNF768 levels decrease in response to replicative-, stress- and oncogene-induced senescence. Interestingly, ZNF768 overexpression contributes to bypass RAS-induced senescence by repressing the p53 pathway. Furthermore, we show that ZNF768 interacts with and represses p53 phosphorylation and activity. Cancer genomics and immunohistochemical analyses reveal that ZNF768 is often amplified and/or overexpressed in tumors, suggesting that cells could use ZNF768 to bypass senescence, sustain proliferation and promote malignant transformation. Thus, we identify ZNF768 as a protein linking oncogenic signaling to the control of cell fate decision and proliferation.


Subject(s)
Cellular Senescence/genetics , Genes, ras/genetics , Transcription Factors/genetics , Transcription Factors/metabolism , Carcinogenesis , Cell Cycle , Cell Differentiation , Cell Proliferation , Cell Transformation, Neoplastic , DNA Replication , Gene Expression Regulation, Neoplastic , Gene Knockdown Techniques , Genomics , HeLa Cells , Humans , Oncogenes , Phenotype , Phosphoproteins , Phosphorylation , Repression, Psychology , Signal Transduction , ras Proteins/genetics
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