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Clin Infect Dis ; 50(3): 387-90, 2010 Feb 01.
Article in English | MEDLINE | ID: mdl-20047481

ABSTRACT

We report the selection of enfuvirtide-resistant human immunodeficiency virus type 1 in cerebrospinal fluid, resulting in subsequent loss of viral suppression in the plasma. This case report emphasizes the potential danger of low-level penetration of entry inhibitors into the central nervous system.


Subject(s)
Anti-HIV Agents/pharmacology , Cerebrospinal Fluid/virology , Drug Resistance, Viral , HIV Envelope Protein gp41/pharmacology , HIV Infections/drug therapy , HIV-1/drug effects , Peptide Fragments/pharmacology , Anti-HIV Agents/therapeutic use , Enfuvirtide , HIV Envelope Protein gp41/therapeutic use , HIV Infections/virology , HIV-1/isolation & purification , Humans , Male , Middle Aged , Peptide Fragments/therapeutic use , Selection, Genetic , Treatment Failure
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