ABSTRACT
Kallman syndrome develops as a result of impaired migration of neuronal (gonadotropin-releasing hormone) -producing cells from the medial olfactory zone of the brain into the preoptic nuclei of the hypothalamus. Currently, the connection between the development of olfactogenital dysplasia and a mutation of a gene located in the region of the p. 22.3 of the X chromosome has been proved. Clinically, olfactogenital dysplasia in women is manifested by primary amenorrhea and, as a result, by primary infertility. On examination, a physique of the eunuchoid type can be detected, moderate development of the mammary glands is rarely observed. In men - hypoplastic testicles, eunuchoid appearance is formed by adolescence (high growth, prepubertal testicles, infantile penis, complete absence of secondary sexual characteristics). This article presents the own results of a patient with Kallman syndrome.
