[Neurochemical analysis of the amygdala basolateral nucleus of rats during anxiety tests]. / Neirokhimicheskii analiz bazolateral'nogo iadra mindaliny v razlichnykh testakh trevogi u krys.

Chlordiazepoxid, phenibut, indoter, campiron, campironin, when administered into the amygdala, improve the anxiety condition of rats in avoidance tests and resemble by their effects dophamine, GABA, or serotonin. Observed differences in the anxiolytic effects between anxiosedative and anxioselective agents seem to be due to an unequal contribution of the monoamin- and aminoacidotergic transmitters into the mechanisms of heteromodal aversive anxiety genesis in the basolateral area of the amygdalar complex.

[The neurochemical mechanisms of the central amygdaloid nucleus and the anxiolytic action of tranquilizers in different models of anxiety states]. / Neirokhimicheskie mekhanizmy tsentral'nogo iadra mindalevidnogo kompleksa i anksioliticheskoe deistvie trankvilizatorov v razlichnykh modeliakh trevozhnykh sostoianii.

Chemical stimulation of the central nucleus of the amygdalar complex was carried out in rats during performance of tests of avoidance of "lighted square" and "threatening situation". Microinjections of monoamines, GABA, glutamate, some of their receptor agonists and antagonists revealed neurochemical heterogeneity of the structure and functional ambiguity of neurotransmitter systems in genesis of anxiety of different aversive modes. Chlordiazepoxid, phenibut, indoter, campiron, campironin decrease anxiety in the tests of avoidance of "lighted square" and "threatening situation", their effects being similar to those of dopamine, GABA, or serotonin. A conclusion is made that distinctions in spectra of anxiosedative and anxioselective drugs under study may be caused by unequal contribution of monoamine and amino acid transmitter mechanisms of the central region of the amygdalar complex in genesis of heteromodal aversive anxiety.

[The functional role of monoaminergic and amino acid-ergic mechanisms of the locus coeruleus in anxiety from different aversive origins]. / Funktsional'naia rol' monoamin- i aminokislotergicheskikh mekhanizmov locus coeruleus v trevoge razlichnogo aversivnogo geneza.

Dopamine and glutamine acid microinjection in the locus coeruleus of rats does not influence the alarm state in the test of "Threatening situation" avoidance, but weakens the state of alarm in the test of "illuminated site" avoidance. The local injection of GABA and noradrenaline mesatone effect imitators in this brain formation weakens the alarm state in the test of "threatening situation" avoidance but is not effective in the test of "illuminated site" avoidance. On the contrary, the chemical stimulation of locus coeruleus by serotonin influences the anxiolytic effect in two different experimentally modelled states of alarm. The participation of locus coeruleus and acidergic mechanisms in anxiety of diverse aversive genesis is discussed.