The Lip Flip for Beautification and Rejuvenation of the Lips.

BACKGROUND: The lower third of the face, especially the lips, offer a pivotal contribution to the overall facial appearance. Hyaluronic acid fillers are widely used for lower face support and beautification. OBJECTIVE: This study presents a novel perioral rejuvenation technique. Methods: 70 females were enrolled in the study. The injection technique utilized cannula with bilateral single-entry points. Two different evaluation systems were used. RESULTS: In the upper white lip area, the distances exhibited significant shortening difference before and after treatment in both age groups (P<0.001 for all measurements). Improvement was generally higher among patients injected more than one session. In the lower white lip and chin, the agreement level by physician and patients was fair (P<0.001) while by observers and patients was moderate (P<0.001). CONCLUSIONS: The lip flip technique is a novel, safe and effective additive for perioral rejuvenation. J Drugs Dermatol. 2022;21(1):71-76. doi:10.36849/JDD.6344R1.

The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea.

BACKGROUND: Erythematotelangiectatic rosasea is a common,chronic, relapsing disease characterized mainly by vascular components, for which many therapies may exist but with limited efficacy. OBJECTIVES: We decided to test the efficacy of tranexamic acid when applied topically on the affected areas.,Tranexamic acid is an antifibrinolytic,thus we considered it could be effective at this type of rosacea. METHODS: This is an unblinded study. We included 20 patients, having erythematotelangiectatic rosacea. All patients were women between 27 and 65 years-old. We divided the patients in two groups,the first group was treated only with tranexamic acid solution (Transamin inj/sol 500 mg/5 mL) infused wet dressing for 20 minutes, and the second group was treated with microneedling simultaneously with tranexamic acid solution topical application followed by tranexamic acid solution infused dressing therapy,every 15 days for four sessions. RESULTS: The improvement assecion was outlined according to the Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) and the use of clinical photos and dermoscopy. All patients were improved in the end of the therapy. There was statistically significant improvement, 2 units IGA-RSS in the first group, whereas 3 units IGA-RSS in the second group. The improvement lasted more than four months. The tolerability of the use of tranexamic acid was also asessed. CONCLUSIONS: According to our results a new really promising simple, safe and cheap treatment option targeting mainly to the vascular net and the erythema of rosacea is proposed.