Actigraphy-based sleep and activity measurements in intensive care unit patients randomized to ramelteon or placebo for delirium prevention.

Patients in the ICU often sleep poorly for various reasons, which may predispose to delirium. We previously conducted a clinical trial in which we tested the efficacy of ramelteon, a melatonin-receptor agonist used to treat insomnia, versus placebo, in preventing ICU delirium in patients who underwent elective pulmonary thromboendarterectomy (PTE) surgery. Here we examine sleep, activity, and circadian patterns, measured with actigraphy, to understand changes in these metrics with our intervention and in those with and without delirium. Participants wore wrist actigraphy devices while recovering post-operatively in the ICU. For sleep analysis, we extracted total sleep time and sleep fragmentation metrics over the 22:00 to 06:00 period nightly, and daytime nap duration from the daytime period (0:600 to 22:00) for each participant. For activity analyses, we extracted the following metrics: total daytime activity count (AC), maximum daytime AC, total nighttime AC, and maximum nighttime AC. Next, we performed a nonparametric circadian analysis on ACs over each 24-h day and extracted the following: interdaily stability (IS), intra-daily variability (IV), relative amplitude (RA), and low and high periods of activity (L5 and M10) as well as their start times. These metrics were compared between patients who received ramelteon versus placebo, and between patients who became delirious versus those who did not develop delirium. We additionally made comparisons between groups for daytime and nighttime light levels. No differences in sleep, activity, circadian metrics or light levels were found between drug groups. Delirious patients, when compared to those who were never delirious, had a lower IS (0.35 ± 0.16 vs. 0.47 ± 0.23; P = 0.006). Otherewise, no differences in IV, L5, M10, or RA were found between groups. L5 and M10 activity values increased significantly over the post-extubation for the whole cohort. No differences were found for daytime or nighttime light levels between groups. Overall, ramelteon did not impact sleep or circadian metrics in this cohort. Consistent with clinical experience, delirious patients had less inter-daily stability in their rest-activity rhythms. These data suggest that actigraphy might have value for individual assessment of sleep in the ICU, and for determining and detecting the impact of interventions directed at improving sleep and circadian activity rhythms in the ICU.Trial registration: REGISTERED at CLINICALTRIALS.GOV: NCT02691013. Registered on February 24, 2016 by principal investigator, Dr. Robert L. Owens.

Impact of Nares Swabs in the Operative Management of Distal Lower Extremity Infections.

Associations between nares surveillance cultures and lower extremity wound cultures remains a topic of discussion in the literature and in clinical practice. Reports are limited due to the questionable accuracy of bedside foot cultures. A retrospective review of our institution's lower extremity wounds requiring surgical management distal to the tibial tuberosity was conducted. Deep intraoperative tissue cultures collected in a sterile operating field were referenced against nares cultures from the same hospitalization. Accuracy, sensitivity, and specificity of nares cultures for predicting methicillin-resistant Staphylococcus aureus (MRSA) infection were determined. Four hundred and forty unique patients with both nares and wound cultures met inclusion criteria. Comorbid diagnoses revealed 66.82%, 30.68%, and 32.27% of patients had diabetes mellitus, chronic kidney disease, and/or peripheral arterial disease, respectively. Sensitivity and specificity were found to be 53.13% and 96.13%, respectively. Prevalence of MRSA in a lower extremity wound was 14.9%, and accuracy of nares culture was 90.04% (CI: 86.91%-92.65%). A review of 30 false negative cases was conducted. Using exclusion criteria of a hospital admission within 60 days of presentation, history of MRSA infection, and/or presentation from a long-term care facility, negative predictive value of MRSA nares colonization was 99.51%. A case of necrotizing fasciitis accounted for one outlier. This data demonstrates that nares surveillance swabs have excellent diagnostic performance in ruling out MRSA infections in foot and ankle wounds. Further analysis is required to determine whether this performance is improved in specialized subgroups or dependent on temporal proximity.