[The efficacy of bacteriophage preparations in treating inflammatory urologic diseases]. / Effektivnost' preparatov bakteriofagov pri lechenii vospalitel'nykh urologicheskikh zabolevanii.

Urinary infection is the most commonly encountered hospital infection. Antibacterial therapy promotes selection and dissemination of polyresistant microorganism strains, development of intestinal dysbacteriosis, reduction of intestinal contamination resistance. Clinical and bacteriological efficacy of urinary infection treatment with bacteriophage preparations (pyocyanic, proteus, staphylococcal, coliphage, combined pyobacteriophage) was studied. Sensitivity of the infective agent phage isolated from urological patients was tested before treatment. The preparations were adapted to recently isolated agents from urological patients to raise phage sensitivity of the strains. A total of 293 strains were studied. Phage sensitivity made up 68.9%. Bacteriophage preparations were used both locally and orally in 46 patients with acute and chronic urogenital inflammation. Bacteriological efficacy amounted to 84%, clinical one to 92%. It is inferred that phagotherapy is effective and safe therapeutic modality in the treatment of urinary infection in monotherapy and in combination with antibiotics.

[Effect of the conditions for dynamic homogeneous batch stab cultivation on the reproductive process in Shigella sonnei bacteriophages]. / Vliianie uslovii periodicheskogo dinamicheskogo gomogennogo glubinnogo kul'tivirovaniia na protsess reproduktsii bakteriofagov SHigella sonnei.

The use of the bacterial population, exponentially multiplying in the newly developed cultivation process, ensures the optimum conditions for the dynamic batch cultivation of S. sonnei bacteriophages. The yield of bacteriophage biomass has been found to depend on the concentration of bacterial cells, the oxygen saturation of the medium and the concentration of glucose and amino acids in the medium.