Deep Learning Capabilities for the Categorization of Microcalcification.

Breast cancer is the most common cancer in women worldwide. It is the most frequently diagnosed cancer among women in 140 countries out of 184 reporting countries. Lesions of breast cancer are abnormal areas in the breast tissues. Various types of breast cancer lesions include (1) microcalcifications, (2) masses, (3) architectural distortion, and (4) bilateral asymmetry. Microcalcification can be classified as benign, malignant, and benign without a callback. In the present manuscript, we propose an automatic pipeline for the detection of various categories of microcalcification. We performed deep learning using convolution neural networks (CNNs) for the automatic detection and classification of all three categories of microcalcification. CNN was applied using four different optimizers (ADAM, ADAGrad, ADADelta, and RMSProp). The input images of a size of 299 × 299 × 3, with fully connected RELU and SoftMax output activation functions, were utilized in this study. The feature map was obtained using the pretrained InceptionResNetV2 model. The performance evaluation of our classification scheme was tested on a curated breast imaging subset of the DDSM mammogram dataset (CBIS-DDSM), and the results were expressed in terms of sensitivity, specificity, accuracy, and area under the curve (AUC). Our proposed classification scheme outperforms the ability of previously used deep learning approaches and classical machine learning schemes.

Fractional Model with Social Distancing Parameter for Early Estimation of COVID-19 Spread.

COVID-19 disease has come up as a life-threatening outbreak at end of 2019. It has impacted almost all countries in the world. The major source of COVID-19 is a novel beta coronavirus. COVID-19 had a great impact on world throughout the year 2020. Now, the situation is becoming normal due to the invention of the vaccine. All major countries started large vaccination drives. Mathematical models are used to study the impact of different measures used to decrease pandemics. Mathematical models such as susceptible-infected-removed model and susceptible-exposed-infected-removed are used to predict the spread of diseases. But these models are not suitable to predict COVID-19 spread due to various preventive measures (social distancing and quarantine) applied to reduce spread. Hence, in the present manuscript, a novel fractional mathematical model with a social distancing parameter has been proposed to provide early COVID-19 spread estimation. Fractional calculus provides flexibility in choosing arbitrary order of derivative which controls data sensitivity. The model has been validated with real data set. It has been observed that the proposed model is highly accurate in spread estimation.

Kalman filter based short term prediction model for COVID-19 spread.

Corona Virus Disease 2019 (COVID19) has emerged as a global medical emergency in the contemporary time. The spread scenario of this pandemic has shown many variations. Keeping all this in mind, this article is written after various studies and analysis on the latest data on COVID19 spread, which also includes the demographic and environmental factors. After gathering data from various resources, all data is integrated and passed into different Machine Learning Models in order to check its appropriateness. Ensemble Learning Technique, Random Forest, gives a good evaluation score on the tested data. Through this technique, various important factors are recognized and their contribution to the spread is analyzed. Also, linear relationships between various features are plotted through the heat map of Pearson Correlation matrix. Finally, Kalman Filter is used to estimate future spread of SARS-Cov-2, which shows good results on the tested data. The inferences from the Random Forest feature importance and Pearson Correlation gives many similarities and few dissimilarities, and these techniques successfully identify the different contributing factors. The Kalman Filter gives a satisfying result for short term estimation, but not so good performance for long term forecasting. Overall, the analysis, plots, inferences and forecast are satisfying and can help a lot in fighting the spread of the virus.

Globally supported radial basis function based collocation method for evolution of level set in mass segmentation using mammograms.

Computer-aided detection systems play an important role for the detection of breast abnormalities using mammograms. Global segmentation of mass in mammograms is a complex process due to low contrast mammogram images, irregular shape of mass, speculated margins, and the presence of intensity variations of pixels. This work presents a new approach for mass detection in mammograms, which is based on the variational level set function. Mesh-free based radial basis function (RBF) collocation approach is employed for the evolution of level set function for segmentation of breast as well as suspicious mass region. The mesh-based finite difference method (FDM) is used in literature for evolution of level set function. This work also showcases a comparative study of mesh-free and mesh-based approaches. An anisotropic diffusion filter is employed for enhancement of mammograms. The performance of mass segmentation is analyzed by computing statistical measures. Binarized statistical image features (BSIF) and variants of local binary pattern (LBP) are computed from the segmented suspicious mass regions. These features are given as input to the supervised support vector machine (SVM) classifier to classify suspicious mass region as mass (abnormal) or non-mass (normal) region. Validation of the proposed algorithm is done on sample mammograms taken from publicly available Mini-mammographic image analysis society (MIAS) and Digital Database for Screening Mammography (DDSM) datasets. Combined BSIF features perform better as compared to LBP variants with the performance reported as 97.12% sensitivity, 92.43% specificity, and 98% AUC with 5.12 FP/I on DDSM dataset; and 95.12% sensitivity, 92.41% specificity, and 95% AUC with 4.01FP/I on MIAS dataset.