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1.
Dent Mater J ; 41(1): 78-86, 2022 Feb 01.
Article in English | MEDLINE | ID: mdl-34483201

ABSTRACT

The aim of this study was to compare the local and systemic effects of current pulp capping materials containing resin with those of traditional materials in an animal study. A total of 48 rats were used: a control group (n=12) (sub-control and negative control), a resin-containing group (n=18) (Calcimol LC, Theracal LC, Activa-BioActive Base/Liner), and a traditional group (n=18) (Biodentine, ProRoot MTA, Dycal). The materials which had been placed in polyethylene tubes were implanted in subcutaneous pockets. The rats were sacrificed at 1, 2, or 4 weeks. Evaluations were made of subcutaneous connective tissue, the left kidney, liver, and blood samples. Of all the study groups, MTA demonstrated biocompatibility at a level close to that of the control groups. Inflammation was observed to be more severe in resin-containing materials, but Activa Base/Liner showed a more successful local and systemic tissue response.


Subject(s)
Dental Pulp Capping , Pulp Capping and Pulpectomy Agents , Aluminum Compounds , Animals , Calcium Compounds , Dental Pulp , Oxides , Pulp Capping and Pulpectomy Agents/pharmacology , Rats , Silicates/pharmacology
2.
Oral Health Prev Dent ; 16(6): 525-532, 2018.
Article in English | MEDLINE | ID: mdl-30511051

ABSTRACT

PURPOSE: To qualitatively and quantitatively compare the cytotoxic potentials of five different one-step self-etching adhesives: Prime&Bond One-Select (PB-OS), Optibond All-in-One (OB-AIO), G-Bond (GB), Clearfil Universal Bond (CUB), Single Bond Universal (SBU). MATERIALS AND METHODS: During the first stage of the study, the cytotoxic activities of the test materials were evaluated qualitatively using the direct contact method. In this method, the test materials were placed directly into a monkey kidney epithelial cell culture medium. Reaction zones which occurred in the culture medium were evaluated, in addition to the density and changes in the morphology of the cells. During the second stage, the cytotoxic potential of four different dilutions (1%, 0.1%, 0.01%, 0.001%) of the test materials on L929 rat fibroblast cells was quantitatively evaluated at three different time periods (24 h, 48 h, 72 h) with the MTT tetrazolium-based assay. RESULTS: In the first stage, a zone exceeding 1 cm was observed around or below SBU, CUB, GB and OB-AIO. In PB-OS, the zone borders were approximately 1 cm. In the second stage after the MTT assay, CUB was the most cytotoxic after 24 h, GB and SBU after 48 h, and OB-AIO after 72 h. CONCLUSION: All adhesives tested showed different degrees of cytotoxicity, which statistically significantly increased with dose. Changes were seen related to time.


Subject(s)
Dental Cements/toxicity , Materials Testing , Acid Etching, Dental , Animals , Bisphenol A-Glycidyl Methacrylate/toxicity , Cells, Cultured , Evaluation Studies as Topic , Haplorhini , Methacrylates/toxicity , Polymethacrylic Acids/toxicity , Qualitative Research , Rats , Resin Cements/toxicity , Toxicity Tests/methods
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