ABSTRACT
The study aims to observe whether subjects with a primary affective disease and manic attacks show modifications of serum concentration of creatine-kinase conferring it the role of a biologic marker. Serum concentration of creatine-kinase was determined for 122 men with mono- and bipolar affective disease during the different stages as well as for schizophrenic men with different clinical forms excepting the affective form. The control group included 60 men. Data indicated that enzyme concentration can constitute a biological marker for a primary affective disease also showing the differences between the different stages of the disease (mania, hypomania, depression and the symptom-free intervals).
Subject(s)
Bipolar Disorder/diagnosis , Clinical Enzyme Tests , Creatine Kinase/blood , Adult , Biomarkers/blood , Humans , Male , Reference Values , Schizophrenia/diagnosisABSTRACT
Carried out on 57 outpatients, the study was aimed to prove the existence of a disgammaglobulinemia in Down's syndrome. The event could not be attributed to hospitalization. Data indicate increased A and G immunoglobulinemias. In agreement with other authors Ig A level was found to be very high especially after the age of 5. Ig M titre in patients was reduced in comparison with that of the controls, regardless of the age group. Increase timing of IgA and Ig G concentrations tends to be more marked for the Ig A fraction. In patients ranging from 0 to 5 years the Ig A serum level is deficient.
Subject(s)
Antibody Formation/immunology , Down Syndrome/immunology , Hospitalization , Adolescent , Age Factors , Child , Child, Preschool , Female , Humans , Immune Tolerance/immunology , Immunoglobulins/analysis , Infant , MaleABSTRACT
Immunoglobulin levels (A, G, M) were measured with Mancini's radial immunodiffusion technique (RID). IgA and IgG levels showed a statistically significant increase in schizoaffective patients compared to normals, and schizophrenics, but no modification in comparison with the affective patients. IgM also showed a statistically significant increase which may constitute a trait marker for the schizoaffective disease.
Subject(s)
Antibody Formation/immunology , Bipolar Disorder/immunology , Depressive Disorder/immunology , Immunoglobulins/analysis , Schizophrenia/immunology , Adolescent , Adult , Bipolar Disorder/diagnosis , Depressive Disorder/diagnosis , Female , Humans , Middle Aged , Schizophrenia/diagnosisABSTRACT
Quantitative determination of serum immunoglobulins (A, G, M) was made in patients with primary bipolar affective disorders (PBAD) and adequate control samples. Considering the modified immunoglobulin levels, the immune factors may be incriminated in the etiopathogenesis of the disease.
Subject(s)
Bipolar Disorder/immunology , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Adult , Biomarkers/blood , Female , Humans , Immunodiffusion , Male , Middle Aged , Recurrence , Sex CharacteristicsABSTRACT
The paper aims at finding whether the serum creatine-kinase activity may be considered as a biological state or a trait-marker in major depression. The study performed in 76 patients (males and females) led to the conclusion that significant increases of the enzymic activity as compared with controls are present in depressive and not in euthymic patients. The same significant increase was found when comparing the depressive and euthymic patients (but not in the group of monopolar depressive females). There were no significant differences between the monopolar and the bipolar form of the disease. The data reported by the authors show that serum creatine-kinase is not a trait-marker in primary affective illness, but it may be taken for a state-marker in this disease. However, the enzyme is not a biochemical discriminant for the type of depression.
Subject(s)
Clinical Enzyme Tests , Creatine Kinase/blood , Depressive Disorder/diagnosis , Adult , Biomarkers/blood , Bipolar Disorder/diagnosis , Diagnosis, Differential , Female , Humans , MaleABSTRACT
Hippocampic and brain stem levels of amino acids were determined in audiogenic seizure-susceptible rats following habituation by repeated exposure to the acoustic stimulus. The biochemical determinations were performed in the brains of 42 habituated animals and 23 not habituated seizure susceptible rats used as controls. It was found that the habituation process is associated with: a) increased levels of aspartate in hippocampus and pons; b) significantly decreased levels of glycine in the hippocampus and pons; c) decreased concentration of glutamate in the pons; d) no significant changes in the GABA concentrations in hippocampus and brain stem. The changes of the excitatory and inhibitory amino acids in the brain of the habituated rats cannot explain the fall in epileptic susceptibility associated with habituation.
Subject(s)
Amino Acids/physiology , Brain/physiopathology , Habituation, Psychophysiologic/physiology , Seizures/physiopathology , Acoustic Stimulation , Animals , Brain Mapping , RatsABSTRACT
The beta-glycerophosphatase (GP), p-nitrophenyl phosphatase (PNFP) and beta-glucuronidase (BG) activities in four neocortical rabbit areas have been determined in six successive electrocorticographic stages of postnatal ontogenetic development of epileptic reactivity. The lysosomal enzyme activity decreases gradually from rabbits aged 1 day to adult ones and is similar within the four neocortical areas. The activity of the three lysosomal enzymes is not parallel. Statistically significant decreases in beta-glycerophosphatase activity are present in rabbits at the age of 30 days versus adult age in all the areas investigated while beta-glucuronidase is higher at the same developmental stage only in beta retrosplenial (III) and motor (II) areas. Correlation of the electrophysiological and biochemical data cannot provide explanation for the particular phenomena of the epileptogenic reactivity in rabbit cerebral neocortex.
Subject(s)
Aging/metabolism , Brain/enzymology , Epilepsy/enzymology , Lysosomes/enzymology , 4-Nitrophenylphosphatase/analysis , 4-Nitrophenylphosphatase/metabolism , Animals , Brain Chemistry/physiology , Electroencephalography , Epilepsy/etiology , Glucuronidase/analysis , Glucuronidase/metabolism , Lysosomes/analysis , Male , Phosphoric Monoester Hydrolases/analysis , Phosphoric Monoester Hydrolases/metabolism , RabbitsSubject(s)
Autistic Disorder/etiology , Asphyxia Neonatorum/complications , Autistic Disorder/metabolism , Autistic Disorder/pathology , Bacterial Infections/complications , Birth Injuries/complications , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Nervous System Diseases/complications , Pregnancy , Pregnancy Complications , Virus Diseases/complicationsSubject(s)
Brain Ischemia/epidemiology , Adult , Age Factors , Female , Humans , Male , Middle Aged , RiskABSTRACT
In a group of 38 epileptics, 13.1 % had alterations of serum lipids before administration of antiepileptic therapy. An inverse relation was found between the level of serum lipids and that of drug concentration : on minimal daily doses, phenobarbital attained disproportionally high concentrations in a patient with hypocholesterolemia + hypotriglyceridemia, while on large daily doses phenobarbital and/or diphenylhydantoin attained low concentrations in the patients with hypercholesterolemia alone or accompanied by hypertriglyceridemia.
