1.
ChemMedChem
; 18(4): e202200526, 2023 02 14.
Article
in English
| MEDLINE
| ID: mdl-36367256
ABSTRACT
Paracetamol and valproic acid are standalone drugs with leading position in the world drug market. The phosphonate analogues of these drugs were synthesized and were tested inâ vivo. N-(4-hydroxyphenylcarbamoyl)phosphonic acid was four times more potent than paracetamol in preventing acetic acid-induced writhing. Phosphonate derivative of valproic acid, (2-propylpentanoyl)phosphonic acid, had similar inâ vivo activity to valproic acid in the pentylenetetrazole-induced kindling mouse model.