Transmission optimized LWIR metalens.

Thermal imaging at the infrared wavelength regime has long been applied to different areas such as agriculture and defense industries. Metasurfaces, 2D engineered ultra-thin structures, have attracted much attention due to their compact size, superior performance, and different functionalities at optical frequencies. This work details the design and fabrication of high transmission metalenses operating at the long-wave infrared (LWIR) spectrum. We minimize the reflection losses through anti-reflection coating (ARC) while maintaining the full wavefront control at the central wavelength 9.07 µm. Our unit cell structure provides an average transmission of 97.5%. We experimentally verify our results and show that the fabricated metalenses perform diffraction-limited imaging at the design wavelength.

Six shades lighter: a bit-serial implementation of the AES family.

Recently, cryptographic literature has seen new block cipher designs such as PRESENT, GIFT or SKINNY that aim to be more lightweight than the current standard, i.e., AES. Even though AES family of block ciphers were designed two decades ago, they still remain as the de facto encryption standard, with AES-128 being the most widely deployed variant. In this work, we revisit the combined one-in-all implementation of the AES family, namely both encryption and decryption of each AES-128/192/256 as a single ASIC circuit. A preliminary version appeared in Africacrypt 2019 by Balli and Banik, where the authors design a byte-serial circuit with such functionality. We improve on their work by reducing the size of the compact circuit to 2268 GE through 1-bit-serial implementation, which achieves 38% reduction in area. We also report stand-alone bit-serial versions of the circuit, targeting only a subset of modes and versions, e.g., AES-192 and AES-256. Our results imply that, in terms of area, AES-192 and AES-256 can easily compete with the larger members of recently designed SKINNY family, e.g., SKINNY-128-256, SKINNY-128-384. Thus, our implementations can be used interchangeably inside authenticated encryption candidates such as SKINNY-AEAD/-HASH, ForkAE or Romulus in place of SKINNY.

Rotationally tunable varifocal 3D metalens.

Varifocal optics have a variety of applications in imaging systems. Metasurfaces offer control of the phase, transmission, and polarization of light using subwavelength engineered structures. However, conventional metasurface designs lack dynamic wavefront shaping which limits their application. In this work, we design and fabricate 3D doublet metalenses with a tunable focal length. The phase control of light is obtained through the mutual rotation of the singlet structures. Inspired by Moiré lenses, the proposed structure consists of two all-dielectric metasurfaces. The singlets have reverse-phase profiles resulting in the cancellation of the phase shift in the nominal position. In this design, we show that the mutual rotation of the elements produces different wavefronts with quadratic radial dependence. Thus, an input plane wave is converted to spherical wavefronts whose focal length depends on the rotation. We use a combination of a nanopillar and a phase plate as the unit cell structure working at a wavelength of 1500 nm. Our design holds promise for a range of applications such as zoom lenses, microscopy, and augmented reality.

Hybrid metasurfaces for simultaneous focusing and filtering.

This work presents the design and fabrication of polymeric, structural optical filters that simultaneously focus light. These filters represent a novel, to the best of our knowledge, design at the boundary between diffractive optics and metasurfaces that may provide significant advantages for both digital and hyperspectral imaging. Filters for visible and near-infrared wavelengths were designed using finite-difference time-domain (FDTD) simulations. Prototype filters were fabricated using two-photon lithography, a form of nanoscale 3D printing, and have geometries suitable to replication by molding. The experimentally measured spectral transmission and focused spot size of each filter show excellent agreement with simulation.

Treatment of patients with multiple myeloma over 65 yr: more tolerability or better response?

OBJECTIVE: Two-thirds of newly diagnosed patients with multiple myeloma (MM) are over 65 yr and/or physically unfit. Such patients are not eligible for high-dose chemotherapy or stem cell transplantation. The treatment aims in these patients should be to prolong survival by obtaining the best possible response, while maintaining good tolerability. The aim of our study was to evaluate the response to treatment and treatment-related toxicities in patients treated with conventional and novel protocols. METHODS: The records of 138 elderly (≥65 yr) patients with MM were retrospectively evaluated. RESULTS: The median overall survival(OS) of the patients was 46 months. The median progression-free survival (PFS) was 18 months. The OS and PFS of the patients treated with the conventional protocols did not differ significantly from those treated with the novel protocols. The statistical analysis of the quality of the response to the treatment with the conventional and novel therapies showed that complete remission (CR), combined with a very good partial response (VGPR), was significantly higher in the latter. However, the toxicities were higher in the novel treatment group. CONCLUSION: The novel drug protocols significantly increased the quality of the responses of elderly patients with MM to therapy, but they did not increase the patients' tolerability.