Laser diode based THz-TDS system with 133 dB peak signal-to-noise ratio at 100 GHz.

Terahertz time-domain spectroscopy (THz-TDS) has emerged as a powerful and versatile tool in various scientific fields. These include-among others-imaging, material characterization, and layer thickness measurements. While THz-TDS has achieved significant success in research environments, the high cost and bulky nature of most systems have hindered widespread commercialization of this technology. Two primary factors contributing to the size and cost of these systems are the laser and the optical delay unit (ODU). Consequently, our group has focused on developing THz-TDS systems based on compact monolithic mode-locked laser diodes (MLLDs). The ultra-high repetition rate (UHRR) of the MLLD has the added benefit that it allows us to utilize shorter ODUs, thereby reducing the overall cost and size of our systems. However, achieving the necessary precision in the ODU to acquire accurate terahertz time-domain signals remains a crucial aspect. To address this issue, we have developed and enhanced an interferometric extension for UHRR-THz-TDS systems. This extension is inexpensive, compact, and easy to incorporate. In this article, we present the system setup, the extension itself, and the algorithmic procedure for reconstructing the delay axis based on the interferometric reference signal. We evaluate a dataset comprising 10,000 signal traces and report a standard deviation of the measured terahertz phase at 1.6 THz as low as 3 mrad. Additionally, we demonstrate a remaining peak-to-peak jitter of only 20 fs and a record-high peak signal-to-noise ratio of 133 dB at 100 GHz after averaging. The method presented in this paper allows for simplified THz-TDS system builds, reducing bulk and cost. As a result, it further facilitates the transition of terahertz technologies from laboratory to field applications.

Group velocity dispersion in high-performance BH InAs/InP QD and InGaAsP/InP QW two-section passively mode-locked lasers.

High-performance buried heterostructure (BH) C-band InAs/InP quantum dot (QD) and L-band InGaAsP/InP quantum well (QW) two-section passively mode-locked lasers (MLLs) are investigated. From the irregularity of the longitudinal mode spacing in the comb spectra, we confirm that under stable passive mode locking, both devices have strong group velocity dispersion (GVD) and corresponding GVD-induced pulse width broadening. After compensation with anomalous dispersion fibers (SMF-28), short pulse trains with sub-ps pulse widths are achieved for both devices. This observation demonstrates our ability to generate high peak power sub-ps pulses using QD MLLs and QW MLLs for many photonic applications of optical communications.

Repetition frequency tunability and stability of BH InAs/InP QD and InGaAsP/InP QW two-section mode-locked laser diodes.

Ultra-high repetition rate (UHRR) mode-locked laser diodes (MLLD) have shown promising results for applications based on optical sampling such as asynchronous optical sampling (ASOPS), optical sampling by repetition-rate tuning (OSBERT), and optical ranging. Important metrics to consider are the repetition frequency (RF) and the RF linewidth. Here, we compare two monolithically integrated MLLDs. A quantum dot (QD) MLLD with an RF of approx. 50.1 GHz and a quantum well (QW) MLLD with an RF of approx. 51.4 GHz. The tunability of the RF is characterized by sweeping the lasers pump current, temperature, and saturable absorber (SA) reverse voltage. The QW MLLD has a tuning range of 31 MHz with an average RF linewidth of 53 kHz, while the QD MLLD has a smaller tuning range of 26 MHz with a higher average RF linewidth of 172 kHz.

Ultra-High Repetition Rate Terahertz Time-Domain Spectroscopy for Micrometer Layer Thickness Measurement.

Terahertz time-domain spectroscopy systems driven by monolithic mode-locked laser diodes (MLLDs) exhibit bandwidths exceeding 1 THz and a peak dynamic range that can compete with other state-of-the-art systems. Their main difference compared to fiber-laser-driven systems is their ultra-high repetition rate of typically dozens of GHz. This makes them interesting for applications where the length of the terahertz path may not be precisely known and it enables the use of a very short and potentially fast optical delay unit. However, the phase accuracy of the system is limited by the accuracy with which the delay axes of subsequent measurements are synchronized. In this work, we utilize an all-fiber approach that uses the optical signal from the MLLD in a Mach-Zehnder interferometer to generate a reference signal that we use to synchronize the detected terahertz signals. We demonstrate transmission-mode thickness measurements of stacked layers of 17µm thick low-density polyethylene (LDPE) films.

Wideband Beam Steering Concept for Terahertz Time-Domain Spectroscopy: Theoretical Considerations.

Photonic true time delay beam steering on the transmitter side of terahertz time-domain spectroscopy (THz TDS) systems requires many wideband variable optical delay elements and an array of coherently driven emitters operating over a huge bandwidth. We propose driving the THz TDS system with a monolithic mode-locked laser diode (MLLD). This allows us to use integrated optical ring resonators (ORRs) whose periodic group delay spectra are aligned with the spectrum of the MLLD as variable optical delay elements. We show by simulation that a tuning range equal to one round-trip time of the MLLD is sufficient for beam steering to any elevation angle and that the loss introduced by the ORR is less than 0.1 dB. We find that the free spectral ranges (FSRs) of the ORR and the MLLD need to be matched to 0.01 % so that the pulse is not significantly broadened by third-order dispersion. Furthermore, the MLLD needs to be frequency-stabilized to about 100 MHz to prevent significant phase errors in the terahertz signal. We compare different element distributions for the array and show that a distribution according to a Golomb ruler offers both reasonable directivity and no grating lobes from 50 GHz to 1 THz.

Repeatability of material parameter extraction of liquids from transmission terahertz time-domain measurements.

Recently, many research groups worldwide have reported on the THz properties of liquids. Often these parameters, i.e., refractive index and absorption coefficient, are determined using liquids in cuvettes and terahertz time-domain spectroscopy. Here, we discuss the measurement process and determine how repeatable such measurements and the data extraction are using rapeseed oil as a sample. We address system stability, cuvette positioning, cuvette cleaning and cuvette assembly as sources affecting the repeatability. The results show that system stability and cuvette assembly are the most prominent factors limiting the repeatability of the THz measurements. These findings suggest that a single cuvette with precise positioning and thorough cleaning of the cuvette delivers the best discrimination among different liquid samples. Furthermore, when using a single cuvette and measurement systems of similar stability, the repeatability calculated based on several consecutive measurements is a good estimate to tell whether samples can be discriminated.

System-theoretical modeling of terahertz time-domain spectroscopy with ultra-high repetition rate mode-locked lasers.

Terahertz time-domain spectroscopy (THz-TDS) systems based on ultra-high repetition rate mode-locked laser diodes (MLLDs) and semiconductor photomixers show great potential in terms of a wide bandwidth, fast acquisition speed, compactness, and robustness. They come at a much lower total cost than systems using femtosecond fiber lasers. However, to date, there is no adequate mathematical description of THz-TDS using a MLLD. In this paper, we provide a simple formula based on a system-theoretical model that accurately describes the detected terahertz spectrum as a function of the optical amplitude and phase spectrum of the MLLD and the transfer function of the terahertz system. Furthermore, we give a simple yet exact relationship between the optical intensity autocorrelation and the detected terahertz spectrum. We theoretically analyze these results for typical optical spectra of MLLDs to quantify the effect of pulse chirp on the terahertz spectrum. Finally, we confirm the validity of the model with comprehensive experimental results using a single-section and a two-section MLLD in a conventional THz-TDS system.

Terahertz Beam Steering Concept Based on a MEMS-Reconfigurable Reflection Grating.

With an increasing number of applications of terahertz systems in industrial fields and communications, terahertz beamforming and beam steering techniques are required for high-speed, large-area scanning. As a promising means for beam steering, micro-electro-mechanical system (MEMS)-based reflection gratings have been successfully implemented for terahertz beam control. So far, the diffraction grating efficiency is relatively low due to the limited vertical displacement range of the reflectors. In this paper, we propose a design for a reconfigurable MEMS-based reflection grating consisting of multiple subwavelength reflectors which are driven by 5-bit, high-throw electrostatic actuators. We vary the number of the reflectors per grating period and configure the throw of individual reflectors so that the reflection grating is shaped as a blazed grating to steer the terahertz beam with maximum diffraction grating efficiency. Furthermore, we provide a mathematical model for calculating the radiation pattern of the terahertz wave reflected by general reflection gratings consisting of subwavelength reflectors. The calculated and simulated radiation patterns of the designed grating show that we can steer the angle of the terahertz waves in a range of up to ± 56.4 ∘ with a maximum sidelobe level of -10 dB at frequencies from 0.3 THz to 1 THz.

Application of a robotic THz imaging system for sub-surface analysis of ancient human remains.

We used a robotic-based THz imaging system to investigate the sub-surface structure of an artificially mummified ancient Egyptian human left hand. The results obtained are compared to the results of a conventional CT and a micro-CT scan. Using such a robotic THz system promises new insights into the sub-surface structure of human remains. The depth resolution of the THz images exceeds the resolution of a conventional CT scan and is comparable with a micro-CT scan. The advantage of THz measurements over micro-CT scans is the fact that even comparatively large samples, like complete bodies, can be scanned. These would not fit into a conventional micro-CT scanner.

Effect of Atrial Fibrillation and Mitral Valve Gradients on Response to Percutaneous Mitral Valve Repair With the MitraClip System.

Both pre-existing atrial fibrillation (AF) and mitral valve pressure gradients (MVPG) created by MitraClip implantation have demonstrated predictive power for unfavorable outcomes. Therefore, we aimed to assess the impact of MVPG following MitraClip on outcomes in patients with and without AF. A total of 200 patients who underwent MitraClip implantation in our institution were enrolled. Echocardiography was obtained before and after the procedure. The primary endpoint of the study was all-cause mortality 1-year after MitraClip implantation. Secondary end points were clinical improvements in NYHA functional class and reduction in MR severity after MitraClip implantation. Two hundred patients (74 ± 10 years, left ventricular ejection fraction 41% ± 14%, logistic EuroSCORE I 21 ± 15) were enrolled into the final analysis. One hundred twelve patients (56%) had pre-existing AF. One-year all-cause mortality was 17% without any differences between patients with or without pre-existing AF. Comparing postprocedural MVPG of surviving and deceased patients, deceased patients with pre-existing AF exhibited significantly elevated postprocedural MVPG compared with surviving patients without AF (4.8 ± 2.1 mm Hg vs 3.6 ± 1.8 mm Hg; p = 0.010). ROC analysis and Kaplan-Meier survival curves identified significantly reduced survival in AF patients with postprocedural MVPG above 4.0 mm Hg (p = 0.011). After MitraClip, a MVPG above 4.0 mm Hg in patients with pre-existing AF was a significant outcome predictor in univariate and multivariate analysis. In conclusion, we identified a high-risk cohort characterized by postprocedural MVPG above 4.0 mm Hg and pre-existing AF predicting poor long-term outcome.

Enhancing the performance of THz quasi time-domain spectroscopy systems by low duty cycle laser operation.

We investigate the performance of terahertz (THz) quasi time-domain systems (QTDS) driven by electrically pulsed multi-mode laser diodes operating at 659 nm. We show that at the same average output power, a reduced duty cycle considerably increases the obtained bandwidth. In the presented experiment, the high frequency performance is improved by 50 dB/THz. We identify the broadening of the optical spectrum caused by pulsing the laser source to be responsible for the increased THz bandwidth.

Acute reverse annular remodeling during MitraClip® therapy predicts improved clinical outcome in heart failure patients: a 3D echocardiography study.

BACKGROUND: Transcatheter mitral valve repair (TMVR) has been shown to have acute effects on mitral valve geometry in patients with functional mitral regurgitation (FMR). This study investigates the impact of MitraClip® therapy-induced annular remodeling on clinical outcome and mitral regurgitation in heart failure patients. METHODS: TMVR was performed successfully in 45 patients with FMR. In this study, mitral valve datasets were obtained before and directly after MitraClip® implantation using three-dimensional (3D) transesophageal echocardiography, and were analyzed offline retrospectively using dedicated 3D reconstruction software. Patients underwent clinical and echocardiographic evaluation at baseline and after 6 months. At follow-up, the patients were allocated into two groups according to their improvement in New York Heart Association (NYHA) functional class: a Low Responder group with ΔNYHA <1.5 (n = 25); and a High Responder group with ΔNYHA ≥1.5 (n = 20). RESULTS: At 6-month follow-up, data analysis revealed that while mitral regurgitation was reduced significantly in both groups, only the High Responder group had experienced significant downsizing of the 3D circumference (137 ± 14 mm to 126 ± 13 mm; p < 0.01) and the anterior-to-posterior diameter (33 ± 5 mm to 29 ± 4 mm; p < 0.01) of the mitral annulus during the intervention. Furthermore, only the High Responder group with reverse annular remodeling as shown had substantial advances in quality of life (Minnesota living with heart failure questionnaire: 55 ± 10 to 34 ± 14 points; p < 0.01) and functional status (6-min walk distance: 290 ± 104 m to 462 ± 111 m; p = 0.07). CONCLUSION: Our study demonstrates that instantaneous left ventricular annular remodeling during MitraClip® implantation is associated with improved clinical outcome of heart failure patients with functional mitral regurgitation. Trial registration The study was approved by the local ethics committee (Study Number 4497R, Registration ID: 2013121585). TRIAL REGISTRATION: NCT02033811 Retrospectively registered January 9, 2014.

Terahertz quasi time-domain spectroscopy based on telecom technology for 1550 nm.

We present a fiber-coupled terahertz quasi time-domain spectroscopy system driven by a laser with a central wavelength of 1550 nm. By using a commercially available multimode laser diode in combination with state-of-the-art continuous wave antennas, a bandwidth of more than 1.8 THz is achieved. The peak signal-to-noise ratio is around 60 dB. A simulation based on the optical spectrum of the laser diode and the transfer function of the THz path is in agreement with the experimental results. The system is used to extract the refractive index from two different samples and the results indicate that the performance is up to 1.8 THz comparable to a terahertz time-domain spectroscopy system.

Femtosecond semiconductor laser system with resonator-internal dispersion adaptation.

We present a femtosecond laser diode system that is capable of autonomously adjusting itself to compensate for the external dispersion in an arbitrary application. The laser system contains a spatial light modulator inside the cavity which is controlled by an evolutionary algorithm in order to allow for phase and amplitude shaping of the laser emission. The cavity-internal dispersion control is shown to be much more efficient than an external control with a pulse shaper.

Periodic sampling errors in terahertz time-domain measurements.

An extensive investigation of the origin and the impact of periodic sampling errors of terahertz time-domain spectroscopy systems is given. We present experimental findings and compare them to a theoretical model which is developed in this work. Special attention is given to the influence on the extraction of the refractive index from measurements. It can be shown that even distortions of the spectrum at frequencies higher than the used bandwidth can have a significant impact on the extracted refractive index.

Deep sedation Vs. general anesthesia in 232 patients undergoing percutaneous mitral valve repair using the MitraClip® system.

OBJECTIVES: To investigate in a series of 232 patients whether the MitraClip® procedure can be performed safely using deep sedation (DS) without general anesthesia (GA). BACKGROUND: Transcatheter mitral valve repair using the MitraClip® system is a safe and effective therapy for severe mitral regurgitation (MR) in patients who are at high operative risk or are unsuitable for surgery. For these patients, avoidance of GA might be beneficial. METHODS: Between 2011 and 2015, we performed 232 MitraClip® procedures for the treatment of severe MR. Of those, 76 procedures were performed using GA, while the remaining 156 procedures were performed using DS. RESULTS: Age, logistic EuroScore, severity of MR, left and right ventricular function, and renal function did not differ between the groups. The primary combined safety endpoint, which was defined as the occurrence of major adverse cardiac and cerebrovascular events, conversion to surgery, major vascular complications or pneumonia, did not differ between MitraClip® procedures performed using GA and MitraClip® procedures performed using DS. Intraprocedural conversion to GA was required in 2% of the patients in the DS group. There were no differences in procedural success or clinical outcome between the groups at the 3-month follow-up. Preparation time in the catheterization laboratory and intensive care unit (ICU) stay were shorter in the DS group compared to the GA group. CONCLUSION: The MitraClip® implantation performed using DS is as safe and effective as MitraClip® implantation performed using GA. © 2017 Wiley Periodicals, Inc.

Left Atrial and Left Ventricular Function and Remodeling Following Percutaneous Mitral Valve Repair.

BACKGROUND: Mitral regurgitation causes left atrial (LA) and left ventricular (LV) dysfunction, dilatation, and remodeling. Following percutaneous mitral valve repair (PMVR) using the MitraClip® approach, reverse cardiac remodeling is desirable. To date, the influence of PMVR on LA and segmental LV function and remodeling has not been investigated in detail. METHODS: Twenty-six patients who received the MitraClip device were enrolled in an open-label, single-center observational study. Patients underwent clinical assessment, conventional echocardiography and global and segmental longitudinal strain analysis of the left atrium and left ventricle by speckle tracking echocardiography at baseline and at a three-month follow up. RESULTS: PMVR improved both LV systolic function (from 40.5 ± 2.5% to 45.0 ± 2.5%, p = 0.04) and LV global longitudinal strain (from -8.9 ± 0.7% to -10.7 ± 0.9%, p = 0.004). Segmental analysis revealed improved myocardial deformation mainly in the basal (basalseptal -8.9 ± 0.8% to -12.9 ± 0.8%, p = 0.0002; basallateral -7.9 ± 1.1% to -13.9 ± 1.4%, p = 0.0005) and midventricular segments (mid-septal -12.7 ± 0.9% to -14.5 ± 1.1%, p = 0.02; mid-lateral -7.5 ± 0.8% to -10.8 ± 1.2%, p = 0.006). In patients with pre-procedural preserved LA function with sinus rhythm the impact of PMVR revealed an improvement in LA global conduit function (from 10.6 ± 1.2% to 13.9 ± 1.6%, p = 0.003) and global contractile function (from -2.1 ± 0.47% to -3.5 ± 0.5%, p = 0.03). The reversed remodeling was not associated with altered levels of the cardiac biomarkers matrix metalloproteinase 2 (MMP-2) and MMP-9, tissue-inhibitors of MMPs (TIMP-2 and ST-2). CONCLUSIONS: PMVR improves global segmental LV and LA function and leads to a reverse remodeling.

Optimal C-arm angulation during transcatheter aortic valve replacement: Accuracy of a rotational C-arm computed tomography based three dimensional heart model.

AIM: To investigate the accuracy of a rotational C-arm CT-based 3D heart model to predict an optimal C-arm configuration during transcatheter aortic valve replacement (TAVR). METHODS: Rotational C-arm CT (RCT) under rapid ventricular pacing was performed in 57 consecutive patients with severe aortic stenosis as part of the pre-procedural cardiac catheterization. With prototype software each RCT data set was segmented using a 3D heart model. From that the line of perpendicularity curve was obtained that generates a perpendicular view of the aortic annulus according to the right-cusp rule. To evaluate the accuracy of a model-based overlay we compared model- and expert-derived aortic root diameters. RESULTS: For all 57 patients in the RCT cohort diameter measurements were obtained from two independent operators and were compared to the model-based measurements. The inter-observer variability was measured to be in the range of 0°-12.96° of angular C-arm displacement for two independent operators. The model-to-operator agreement was 0°-13.82°. The model-based and expert measurements of aortic root diameters evaluated at the aortic annulus (r = 0.79, P < 0.01), the aortic sinus (r = 0.93, P < 0.01) and the sino-tubular junction (r = 0.92, P < 0.01) correlated on a high level and the Bland-Altman analysis showed good agreement. The interobserver measurements did not show a significant bias. CONCLUSION: Automatic segmentation of the aortic root using an anatomical model can accurately predict an optimal C-arm configuration, potentially simplifying current clinical workflows before and during TAVR.