ABSTRACT
The coronavirus pandemic is one of the most significant public health events in recent history. Currently, no specific treatment is available. Some drugs and cell-based therapy have been tested as alternatives to decrease the disease's symptoms, length of hospital stay, and mortality. We reported the case of a patient with a severe manifestation of COVID-19 in critical condition who did not respond to the standard procedures used, including six liters of O2 supplementation under a nasal catheter and treatment with dexamethasone and enoxaparin in prophylactic dose. The patient was treated with tocilizumab and an advanced therapy product based on umbilical cord-derived mesenchymal stromal cells (UC-MSC). The combination of tocilizumab and UC-MSC proved to be safe, with no adverse effects, and the results of this case report prove to be a promising alternative in the treatment of patients with severe acute respiratory syndrome due to SARS-CoV-2.
Subject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , COVID-19/therapy , Mesenchymal Stem Cell Transplantation , COVID-19/virology , Combined Modality Therapy , Humans , Immunophenotyping , Karyotyping , Mesenchymal Stem Cells/cytology , Mesenchymal Stem Cells/metabolism , Middle Aged , RNA, Viral/analysis , SARS-CoV-2/genetics , SARS-CoV-2/isolation & purification , Thorax/diagnostic imaging , Tomography, X-Ray Computed , Umbilical Cord/cytology , Viral Load , COVID-19 Drug TreatmentABSTRACT
A presença de síndrome febril na UTI é muito frequente nos pacientes gravemente enfermos. A desregulação da temperatura e o não controle eficiente da mesma, somente apresenta-se em casos isolados. Relataremos um caso em que foi utilizado a técnica da hipotermia terapêutica, julgando- se uma emergência médica, pela temperatura corporal que havia atingido 40 graus centígrados. O objetivo da instituição desta terapêutica foi o de exclusivamente ceder a temperatura.
The presence of febrile syndrome is frequent in ICU is very frequent in patients with severe acute disease. The temperature deregulation and not efficient control of it , only presents in isolated clinical cases. We will present a case that it was used the technique of therapeutic hypothermia, considering a medical emergency, the body temperature that has reached 40 degrees centigrade. The aim institution of this therapy was exclusively give in the body temperature.
Subject(s)
Humans , Therapeutics , Body Temperature , Fever , Hypothermia , Intensive Care UnitsABSTRACT
A correção de aneurisma de aorta abdominal tem sido sua principal indicação o implante de endoprótese (EDV) quando a anatomia for favorável. Apresenta infecção em pós-operatório (PO) baixa, mais relacionados a procedimentos complementares. A ocorrência de fístula aorto-entérica é mais complexa, mas frequentemente associada a infecção pós-EDV. Representa um desafio operatório em um paciente muitas vezes debilitado. A antibioticoterapia é utilizada por longo tempo e de largo espectro. Neste trabalho, apresentaremos um caso de fístula aorto-entérica pós implante de EDV e a conduta que foi realizada para o seu tratamento.
The principal indication for repair of abdominal aortic aneurysm is the endovascular approach when the aortic anatomy is favorable. Graft infection has lower incidence, more related to re-intervations after the endovascular approach. It represents an operational challenge in a often debilitated patient. The antibiotic therapy is long and with a broad spectrum. In this work we will present a case with secondary aortic fistulae after endovascular repair and the decisions for the treatment.
