ABSTRACT
The aim of this study was to evaluate the methylation status of three important cancer related genes viz. p16, E-cadherin and hMLH1 promoters and to associate the findings with specific dietary habits in Kashmiris, a culturally distinct population in India, with gastric cancer. The study subjects were divided into three age groups viz. 0-30 yrs (1st), 31-60 yrs (2nd) and 61-90 yrs (3rd). A highly significant association between the intake of local hot salted tea in 2nd (p=0.001) and 3rd (p=0.009) age groups was observed with the promoter hypermethylation of E cadherin. Again a highly significant association between the aberrant methylation of hMLH1 (p=0.000) and p16 (p=0.000) promoters and the intake of local hot salted tea was observed in the 2nd age group of gastric cancer patients. The intake of sun-dried food was also significantly associated with the promoter hypermethylation of E cadherin (p=0.003) and p16 (p=0.015) genes in 3rd age group. The results of the present study suggest a close association between the aberrant methylation of p16, E-cadherin and hMLH1 promoters and the intake of local hot salted tea and sun-dried foods in Kashmiri population.
Subject(s)
Adaptor Proteins, Signal Transducing/genetics , Cadherins/genetics , DNA Methylation , Food, Preserved , Neoplasm Proteins/genetics , Nuclear Proteins/genetics , Promoter Regions, Genetic/genetics , Stomach Neoplasms/genetics , Tea , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , CpG Islands/genetics , Cyclin-Dependent Kinase Inhibitor p16 , DNA, Neoplasm/genetics , Female , Hot Temperature , Humans , India/epidemiology , Infant , Infant, Newborn , Male , Middle Aged , MutL Protein Homolog 1 , Polymerase Chain Reaction , Prognosis , Stomach Neoplasms/epidemiology , Sunlight , Young AdultABSTRACT
Malignant fibrous histiocytoma MFH is an aggressive spindle cell cancer and is the most common soft tissue tumor in the elderly, primarily affecting the extremities. It has high metastatic potential and can spread to various viscera including liver, lung, bone, and brain; however, cardiac metastasis is an extreme rarity. Here, we present a 50-year-old male, diagnosed as pleiomorhphic storiform MFH a of right arm who developed parenchymal pulmonary metastases and a mass lesion in left atrium. Patient had a downhill course and eventually succumbed.