ABSTRACT
A 57-year-old woman with infiltrating ductal carcinoma of the right breast underwent lymph node scintigraphy with Tc-99m-nanocolloid for preoperative sentinel node localization. On planar images, an unusual pattern of lymphatic drainage was observed. We performed a chest SPECT/CT, revealing an interpectoral sentinel node, ie, Rotter's node. The patient underwent radioguided surgery and the sentinel node was located intraoperatively, and found to be disease-free. SPECT/CT fusion techniques have enhanced precision in locating sentinel nodes, enabling the surgeon to shorten surgical times.
Subject(s)
Lymph Nodes/diagnostic imaging , Technetium Tc 99m Aggregated Albumin , Breast Neoplasms/diagnostic imaging , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Carcinoma, Ductal/diagnostic imaging , Carcinoma, Ductal/pathology , Carcinoma, Ductal/surgery , Female , Humans , Lymph Nodes/pathology , Middle Aged , Radiosurgery , Tomography, Emission-Computed, Single-Photon , Tomography, X-Ray ComputedABSTRACT
The common sequence variants that have recently been associated with cancer risk are particular to a single cancer type or at most two. Following up on our genome-wide scan of basal cell carcinoma, we found that rs401681[C] on chromosome 5p15.33 satisfied our threshold for genome-wide significance (OR = 1.25, P = 3.7 x 10(-12)). We tested rs401681 for association with 16 additional cancer types in over 30,000 cancer cases and 45,000 controls and found association with lung cancer (OR = 1.15, P = 7.2 x 10(-8)) and urinary bladder, prostate and cervix cancer (ORs = 1.07-1.31, all P < 4 x 10(-4)). However, rs401681[C] seems to confer protection against cutaneous melanoma (OR = 0.88, P = 8.0 x 10(-4)). Notably, most of these cancer types have a strong environmental component to their risk. Investigation of the region led us to rs2736098[A], which showed stronger association with some cancer types. However, neither variant could fully account for the association of the other. rs2736098 corresponds to A305A in the telomerase reverse transcriptase (TERT) protein and rs401681 is in an intron of the CLPTM1L gene.
Subject(s)
Membrane Proteins/genetics , Neoplasm Proteins/genetics , Neoplasms/genetics , Polymorphism, Single Nucleotide , Telomerase/genetics , Aged , Carcinoma, Basal Cell/genetics , Case-Control Studies , Female , Gene Frequency , Genetic Predisposition to Disease , Genome-Wide Association Study , Humans , Linkage Disequilibrium , Male , Middle Aged , Polymorphism, Single Nucleotide/physiology , Quantitative Trait Loci , Skin Neoplasms/geneticsABSTRACT
We performed baselineTc(99)-MIBI scanning in 43 patients with multiple myeloma (MM) and in 31 with monoclonal gammopathy of unknown significance (MGUS) patients. We identified two groups of MM patients whose actuarial survival correlated with low or high MIBI scores. MGUS patients had normal or very low scores.
