ABSTRACT
A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglyceride level in alloxan diabetic mice.
Subject(s)
Acridines/chemical synthesis , Benzyl Compounds/chemical synthesis , Hypoglycemic Agents/chemical synthesis , Thiazolidinediones/chemical synthesis , Acridines/chemistry , Acridines/pharmacology , Animals , Benzyl Compounds/chemistry , Benzyl Compounds/pharmacology , Blood Glucose/drug effects , Body Weight/drug effects , Diabetes Mellitus, Experimental/blood , Diabetes Mellitus, Experimental/mortality , Drug Evaluation, Preclinical , Female , Hypoglycemic Agents/pharmacology , Male , Mice , Rosiglitazone , Thiazolidinediones/chemistry , Thiazolidinediones/pharmacology , Triglycerides/bloodABSTRACT
Synthesis and physico-chemical properties of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2-thioxo-imidazolidin-4-ones, 5-benzylidene-3-(4-nitro-benzyl)-2-thioxo-imidazolidin-4-ones and 4-acridin-9-ylmethylene-1-benzyl-5-thioxo-imidazolidin-2-ones compounds are described. These thioxo-imidazolidine derivatives were prepared by alkylation and condensation with 4-fluoro-benzaldehyde or nucleophilic Michael addition with cyanoacrylates. The schistosomicidal activity of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2-thioxo-imidazolidin-4-one compounds was evaluated.