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2.
Phys Rev Lett ; 129(22): 222501, 2022 Nov 23.
Article in English | MEDLINE | ID: mdl-36493444

ABSTRACT

The Cryogenic Underground Observatory for Rare Events (CUORE) at Laboratori Nazionali del Gran Sasso of INFN in Italy is an experiment searching for neutrinoless double beta (0νßß) decay. Its main goal is to investigate this decay in ^{130}Te, but its ton-scale mass and low background make CUORE sensitive to other rare processes as well. In this Letter, we present our first results on the search for 0νßß decay of ^{128}Te, the Te isotope with the second highest natural isotopic abundance. We find no evidence for this decay, and using a Bayesian analysis we set a lower limit on the ^{128}Te 0νßß decay half-life of T_{1/2}>3.6×10^{24} yr (90% CI). This represents the most stringent limit on the half-life of this isotope, improving by over a factor of 30 the previous direct search results, and exceeding those from geochemical experiments for the first time.


Subject(s)
Granisetron , Half-Life , Bayes Theorem
3.
East Asia (Piscataway) ; 39(2): 149-160, 2022.
Article in English | MEDLINE | ID: mdl-34493917

ABSTRACT

The aim of the study is to identify the role of the People's Republic of China in the activities of the organisation, based on the Chinese vision of its role in the Shanghai Cooperation Organisation as one of the ideological and philosophical leaders that determine its focus and ideology. In particular, China implements the principle of polycentrism in Eurasia and interstate partnership and promotes the idea of state-regulated economic globalisation. The methodology of this scientific research is based on the analytical method of studying the issues related to the topic of the scientific research. China proceeds from the concept of ensuring full sovereignty by the member states of the organisation, but against the backdrop of low development rates of national economies (up to 2-2.5%) and lack of awareness by countries of their national interests in the region, Chinese business will strengthen its expansion, relying on both the World Trade Organisation rules and using protectionist measures by absorbing ineffective business entities. China is guided by the principles of non-interference in the internal affairs of other states, while maintaining its socio-political model based on the fusion of the communist ideology and the traditional philosophical doctrines of China and the mentality of the country's population, excluding the democracy export policy, denying the desire for undivided hegemony and to rule the world community. This is confirmed by the main key elements of the People's Republic of China's foreign policy, determined by the Chinese leadership.

4.
Phys Rev Lett ; 126(17): 171801, 2021 Apr 30.
Article in English | MEDLINE | ID: mdl-33988435

ABSTRACT

We measured two-neutrino double beta decay of ^{130}Te using an exposure of 300.7 kg yr accumulated with the CUORE detector. Using a Bayesian analysis to fit simulated spectra to experimental data, it was possible to disentangle all the major background sources and precisely measure the two-neutrino contribution. The half-life is in agreement with past measurements with a strongly reduced uncertainty: T_{1/2}^{2ν}=7.71_{-0.06}^{+0.08}(stat)_{-0.15}^{+0.12}(syst)×10^{20} yr. This measurement is the most precise determination of the ^{130}Te 2νßß decay half-life to date.

5.
Phys Rev Lett ; 124(12): 122501, 2020 Mar 27.
Article in English | MEDLINE | ID: mdl-32281829

ABSTRACT

We report new results from the search for neutrinoless double-beta decay in ^{130} Te with the CUORE detector. This search benefits from a fourfold increase in exposure, lower trigger thresholds, and analysis improvements relative to our previous results. We observe a background of (1.38±0.07)×10^{-2} counts/(keV kg yr)) in the 0νßß decay region of interest and, with a total exposure of 372.5 kg yr, we attain a median exclusion sensitivity of 1.7×10^{25} yr. We find no evidence for 0νßß decay and set a 90% credibility interval Bayesian lower limit of 3.2×10^{25} yr on the ^{130} Te half-life for this process. In the hypothesis that 0νßß decay is mediated by light Majorana neutrinos, this results in an upper limit on the effective Majorana mass of 75-350 meV, depending on the nuclear matrix elements used.

6.
Phys Rev Lett ; 120(13): 132501, 2018 Mar 30.
Article in English | MEDLINE | ID: mdl-29694201

ABSTRACT

The CUORE experiment, a ton-scale cryogenic bolometer array, recently began operation at the Laboratori Nazionali del Gran Sasso in Italy. The array represents a significant advancement in this technology, and in this work we apply it for the first time to a high-sensitivity search for a lepton-number-violating process: ^{130}Te neutrinoless double-beta decay. Examining a total TeO_{2} exposure of 86.3 kg yr, characterized by an effective energy resolution of (7.7±0.5) keV FWHM and a background in the region of interest of (0.014±0.002) counts/(keV kg yr), we find no evidence for neutrinoless double-beta decay. Including systematic uncertainties, we place a lower limit on the decay half-life of T_{1/2}^{0ν}(^{130}Te)>1.3×10^{25} yr (90% C.L.); the median statistical sensitivity of this search is 7.0×10^{24} yr. Combining this result with those of two earlier experiments, Cuoricino and CUORE-0, we find T_{1/2}^{0ν}(^{130}Te)>1.5×10^{25} yr (90% C.L.), which is the most stringent limit to date on this decay. Interpreting this result as a limit on the effective Majorana neutrino mass, we find m_{ßß}<(110-520) meV, where the range reflects the nuclear matrix element estimates employed.

7.
Chemosphere ; 145: 480-6, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26694799

ABSTRACT

A proper soil risk assessment needs to estimate the processes that affect the fate and the behaviour of a contaminant, which are influenced by soil biotic and abiotic components. For this reason, the measurement of biomarkers in soil bioindicator organisms, such as earthworms, has recently received increasing attention. In this study, the earthworm Eisenia andrei was used to assess the pollutant-induced stress syndrome after exposure to sublethal concentrations of Cd (10 or 100 µg g(-1)) in OECD soil, after 14 d of exposure. Cadmium bioaccumulation and potential biomarkers such as catalase (CAT), hydrogen peroxide (H2O2), glutathione-S-transferase (GST), malondialdehyde (MDA), phenoloxidase (PO), metallothioneins (MTs) and genotoxic damage were determined. Results suggested that the exposure to 10 and 100 µg g(-1) Cd significantly increased Cd bioaccumulation, MTs and MDA; 100 µg g(-1) Cd contamination evidenced significantly higher values of H2O2 content and PO activity; CAT activity was inhibited at the higher concentration while GST and Comet assay did not show any significant differences from the control. Rank-based biomarker index showed that both different contaminated soils had an effect on the earthworms and allowed to validate the ecotoxicological relevance of this battery of biomarkers for a promising integrated multi-marker approach in soil monitoring and assessment.


Subject(s)
Biomarkers/analysis , Cadmium/toxicity , Ecotoxicology/methods , Environmental Monitoring/methods , Oligochaeta/drug effects , Soil Pollutants/toxicity , Animals , Biomarkers/metabolism , Cadmium/metabolism , Catalase/analysis , Catalase/metabolism , Comet Assay , Glutathione Transferase/analysis , Glutathione Transferase/metabolism , Hydrogen Peroxide/analysis , Malondialdehyde/analysis , Malondialdehyde/metabolism , Metallothionein/analysis , Metallothionein/metabolism , Oligochaeta/genetics , Oligochaeta/metabolism , Soil Pollutants/metabolism
8.
Phys Rev Lett ; 115(10): 102502, 2015 Sep 04.
Article in English | MEDLINE | ID: mdl-26382673

ABSTRACT

We report the results of a search for neutrinoless double-beta decay in a 9.8 kg yr exposure of (130)Te using a bolometric detector array, CUORE-0. The characteristic detector energy resolution and background level in the region of interest are 5.1±0.3 keV FWHM and 0.058±0.004(stat)±0.002(syst)counts/(keV kg yr), respectively. The median 90% C.L. lower-limit half-life sensitivity of the experiment is 2.9×10(24) yr and surpasses the sensitivity of previous searches. We find no evidence for neutrinoless double-beta decay of (130)Te and place a Bayesian lower bound on the decay half-life, T(1/2)(0ν)>2.7×10(24) yr at 90% C.L. Combining CUORE-0 data with the 19.75 kg yr exposure of (130)Te from the Cuoricino experiment we obtain T(1/2)(0ν)>4.0×10(24) yr at 90% C.L. (Bayesian), the most stringent limit to date on this half-life. Using a range of nuclear matrix element estimates we interpret this as a limit on the effective Majorana neutrino mass, m(ßß)<270-760 meV.

9.
Phys Rev Lett ; 109(7): 070801, 2012 Aug 17.
Article in English | MEDLINE | ID: mdl-23006352

ABSTRACT

We report the measurement of the time of flight of ∼17 GeV ν(µ) on the CNGS baseline (732 km) with the Large Volume Detector (LVD) at the Gran Sasso Laboratory. The CERN-SPS accelerator has been operated from May 10th to May 24th 2012, with a tightly bunched-beam structure to allow the velocity of neutrinos to be accurately measured on an event-by-event basis. LVD has detected 48 neutrino events, associated with the beam, with a high absolute time accuracy. These events allow us to establish the following limit on the difference between the neutrino speed and the light velocity: -3.8 × 10(-6) < (v(ν)-c)/c < 3.1 × 10(-6) (at 99% C.L.). This value is an order of magnitude lower than previous direct measurements.

10.
Phys Rev Lett ; 101(11): 112003, 2008 Sep 12.
Article in English | MEDLINE | ID: mdl-18851276

ABSTRACT

Inclusive K_{S};{0}K_{S};{0} production in ep collisions at the DESY ep collider HERA was studied with the ZEUS detector using an integrated luminosity of 0.5 fb;{-1}. Enhancements in the mass spectrum were observed and are attributed to the production of f_{2}(1270)/a_{2};{0}(1320), f_{2};{'}(1525) and f_{0}(1710). Masses and widths were obtained using a fit which takes into account theoretical predictions based on SU(3) symmetry arguments, and are consistent with the Particle Data Group values. The f_{0}(1710) state, which has a mass consistent with a glueball candidate, was observed with a statistical significance of 5 standard deviations. However, if this state is the same as that seen in gammagamma-->K_{S};{0}K_{S};{0}, it is unlikely to be a pure glueball state.

11.
Res Vet Sci ; 79(3): 225-32, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16054892

ABSTRACT

Steroid receptor expression was assessed by immunohistochemistry in neoplastic, hyperplastic/dysplastic, and normal mammary tissue samples removed from 68 queens and 47 bitches, using monoclonal antibodies against human oestrogen-alpha (ER) and progesterone receptors (PR). Mammary lesions were classified according to World Health Organization (WHO) criteria, and all animals with invasive carcinomas were clinically followed for 2 years. Stromal and/or lymphatic invasion and histological grading were also recorded. In both species, ER expression was significantly higher in healthy tissues, hyperplastic/dysplastic lesions, and benign tumours than in carcinomas. The loss of ER expression was more marked in feline than in canine carcinomas. In queens, PR expression increased in dysplastic lesions and "in situ" carcinomas and decreased in invasive carcinomas, even if parts of these tumours were still PR-positive. In bitches no significant variation in PR expression was observed between normal tissue, dysplasias, and benign neoplasms, but was significantly lower in carcinomas. In both species ER and PR expression in invasive carcinomas did not correlate either with histological parameters or overall survival time. This study demonstrates several differences in steroid hormone dependency between the two species. The percentage of PR-positive feline carcinomas suggests a possible role of progesterone in promoting early tumour cell growth in queens. The low percentage of ER-positive invasive carcinomas further demonstrated the aggressive phenotype and behaviour of feline mammary tumours.


Subject(s)
Cat Diseases/metabolism , Dog Diseases/metabolism , Fibrocystic Breast Disease/metabolism , Mammary Glands, Animal/metabolism , Mammary Neoplasms, Animal/metabolism , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolism , Animals , Cat Diseases/pathology , Cats , Dog Diseases/pathology , Dogs , Female , Fibrocystic Breast Disease/pathology , Fibrocystic Breast Disease/veterinary , Gene Expression Regulation , Immunohistochemistry/veterinary , Mammary Glands, Animal/cytology , Mammary Glands, Animal/pathology , Mammary Neoplasms, Animal/pathology
12.
Vaccine ; 23(7): 910-4, 2005 Jan 04.
Article in English | MEDLINE | ID: mdl-15603892

ABSTRACT

Although the secondary transmission of hepatitis A virus (HAV) infection is preventable through vaccination, it is not known whether the vaccination of household contacts is feasible. To this end, we conducted a prospective cohort study among the household contacts, 40 years of age or less, of all persons infected with primary HAV infection (index cases) and admitted to eight hospitals in southern Italy within 7 days of onset. Household contacts were vaccinated, and serum samples were taken at vaccination and after 14 and 45 days. Secondary cases were defined as those with IgM seroconversion occurring at least two weeks after enrollment. Coprimary cases were those assumed to have had the same exposure as the index case. Susceptible cases were those who were negative for both IgG and IgM. A total of 495 household contacts participated (acceptance rate of 65%); 65% were vaccinated within 4 days of admission of the index case and 95% within 7 days. At enrollment, 196 (39.6%) household contacts were immune (IgG-positive serum). During follow-up, 19 (3.8%) were IgM-positive: 13 (2.6%) were coprimary cases and 6 (1.2%; 95% CI: 0.2-3.2) secondary cases (5 identified at 14 days from vaccination and 1 at 45 days). Of the 241 susceptible cases, 192 (79.7%) had developed IgG antibodies at 14 days and only 3 (1.2%) did not develop IgG antibodies at 45 days. The 65% acceptance rate and the finding that 95% of the participating household contacts were vaccinated within 7 days of the index case's hospitalization indicate that timely vaccination is indeed feasible. The necessity of returning for the collection of blood samples probably decreased the acceptance rate.


Subject(s)
Hepatitis A Virus, Human/immunology , Hepatitis A/prevention & control , Viral Hepatitis Vaccines/therapeutic use , Adolescent , Adult , Child , Child, Preschool , Feasibility Studies , Female , Follow-Up Studies , Hepatitis A/immunology , Humans , Male , Prospective Studies , Viral Hepatitis Vaccines/immunology
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