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2.
Nat Commun ; 8: 15451, 2017 05 16.
Article in English | MEDLINE | ID: mdl-28508897

ABSTRACT

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.


Subject(s)
Biomphalaria/genetics , Biomphalaria/parasitology , Genome , Schistosomiasis mansoni/transmission , Animal Communication , Animals , Biomphalaria/immunology , DNA Transposable Elements , Evolution, Molecular , Fresh Water , Gene Expression Regulation , Host-Parasite Interactions , Pheromones , Proteome , Schistosoma mansoni , Sequence Analysis, DNA , Stress, Physiological
3.
J Insect Sci ; 10: 41, 2010.
Article in English | MEDLINE | ID: mdl-20572793

ABSTRACT

Suppressive subtractive hybridization was used to evaluate the differential expression of midgut genes of feral populations of Aedes aegypti (Diptera: Culicidae) from Colombia that are naturally refractory or susceptible to Dengue-2 virus infection. A total of 165 differentially expressed sequence tags (ESTs) were identified in the subtracted libraries. The analysis showed a higher number of differentially expressed genes in the susceptible Ae. aegypti individuals than the refractory mosquitoes. The functional annotation of ESTs revealed a broad response in the susceptible library that included immune molecules, metabolic molecules and transcription factors. In the refractory strain, there was the presence of a trypsin inhibitor gene, which could play a role in the infection. These results serve as a template for more detailed studies aiming to characterize the genetic components of refractoriness, which in turn can be used to devise new approaches to combat transmission of dengue fever.


Subject(s)
Aedes/metabolism , Aedes/virology , Dengue Virus/physiology , Digestive System/metabolism , Gene Expression Regulation/physiology , Animals , Expressed Sequence Tags , Gene Expression Profiling , Gene Library
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