ABSTRACT
OBJECTIVE: The diagnosis of SARS-CoV-2 infection is crucial for medical and public health reasons, to allow the best treatment of cases and the best control of the pandemic. Serology testing allows for the detection of asymptomatic infections and 19-COVID cases once the virus has been cleared. We analyzed the usefulness of the SARS-CoV-2 rapid test of Autobio and tried to correlate its pattern with the severity of COVID19 infection. METHODS: We analyzed the accuracy and clinical usefulness of a point-of-care IgM and/or IgG test for SARS-CoV-2 in 35 COVID-19 patients [12 (34.3%) mild-moderate and 23 (65.7%) severe-critical] admitted to a field hospital in Madrid, as well as in 5 controls. RESULTS: The mean time from the first day of symptoms to the antibody test was 28 days (SD: 8.7), similar according to the severity of the disease. All patients with SARS-CoV-2 PCR+ showed the corresponding IgG positivity, while these results were negative in all control individuals. A total of 26 (74%) cases also presented with positive IgM, 19 (83%) were severe-critical cases and 7 (58%) were mild-moderate cases. The IgM response lasted longer in the severe critical cases (mean: 29.7 days; SD: 8.4) compared to the moderate cases (mean: 21.2 days; SD: 2.0).. CONCLUSIONS: Rapid serology tests are useful for the diagnosis of patients with COVID-19 (mainly IgG detection) and may also be correlated with the severity of the infection (based on IgM detection).
Subject(s)
Antibodies, Viral/blood , Betacoronavirus/immunology , Clinical Laboratory Techniques/methods , Coronavirus Infections/diagnosis , Pneumonia, Viral/diagnosis , Point-of-Care Testing , Adult , Aged , Asymptomatic Infections , COVID-19 , COVID-19 Testing , Coronavirus Infections/virology , Cross-Sectional Studies , Female , Humans , Immunoassay/methods , Immunoglobulin G/blood , Immunoglobulin M/blood , Male , Middle Aged , Pandemics , Pneumonia, Viral/virology , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2 , Sensitivity and Specificity , Severity of Illness Index , Symptom Assessment/statistics & numerical data , Time FactorsABSTRACT
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Subject(s)
Humans , HIV-1 , Patient Compliance , HIV Infections , Anti-HIV Agents , Antiretroviral Therapy, Highly Active , Pharmaceutical PreparationsABSTRACT
We report a 24-years-old woman who presented with thoracic pain after coughing. Physical exam revealed no abnormalities except pain after pressing under blade-bone area. A rib radiography and CT of the thorax showed a lonely osteolytic lesion inside eleventh left costal arch without affecting others tissues. There were no more osteolytic lesions at other levels and the histopathological study of a resection-biopsy of the lesion was diagnosed as Langerhans' cell granulomatosis. This is an uncommon disease which diagnosis can only be made through histopathological study of suspected lesions.
Subject(s)
Histiocytosis, Langerhans-Cell/diagnosis , Osteolysis/etiology , Ribs , Adult , Female , Histiocytosis, Langerhans-Cell/complications , Humans , Osteolysis/diagnosisABSTRACT
Mujer de 24 años de edad sin antecedentes personales de interés, que consultó por un dolor en región subescapular tras un acceso de tos. En la exploración física no había hallazgos, excepto el dolor a la palpación en la región subescapular. La radiografía de la parrilla costal objetivó una lesión lítica en el undécimo arco costal izquierdo que se confirmó en una TAC de tórax, en la que no había afectación de partes blandas. En el estudio general no se objetivaron otras lesiones líticas a otros niveles ni causa de la lesión, por lo que se realizó una biopsia-excisión, cuyo estudio anatomopatológico fue de Granulomatosis de células de Langerhans unifocal. Es ésta una enfermedad infrecuente, en la que sólo tras el estudio anatomopatológico puede establecerse el diagnóstico (AU)
