ABSTRACT
BACKGROUND: Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate. OBJECTIVE: The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there have been both favorable and unfavorable outcomes documented. METHODS: We performed a systematic review of 116 GMF cases previously described in the literature. RESULTS: In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months. CONCLUSION: GMF is an aggressive form of MF. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.
Subject(s)
Mycosis Fungoides , Skin Neoplasms , Humans , Mycosis Fungoides/pathology , Skin Neoplasms/pathology , Skin Neoplasms/secondary , Lung Neoplasms/pathology , Prognosis , Disease ProgressionABSTRACT
OBJECTIVE: Determine effects on respiratory health of firefighters attending a catastrophic wildfire. METHODS: Within the Alberta Administrative Health Database, we identified five community-based controls for each firefighter in a cohort of 1234 deployed to the 2016 Fort McMurray fire. Spirometry records were identified and a stratified sample assessed clinically. We estimated PM2.5 particles exposure. RESULTS: Firefighters had an increased risk of asthma consultation post-fire (OR new onset asthmaâ=â2.56; 95%CI 1.75 to 3.74). Spirometry showed decreased FEV1 and FVC with increasing exposure. In the clinical assessment, 20% had a positive MCT and 21% BWT. Those with ongoing fire-related symptoms had a higher concurrence of positive MCT and BWT (ORâ=â4.35; 95%CI 1.11 to 17.12). Lower diffusion capacity related to higher exposure. CONCLUSIONS: Massive exposures during a wildfire are associated with non-resolving airways damage.
Subject(s)
Firefighters , Fires , Occupational Exposure , Wildfires , Alberta/epidemiology , Cohort Studies , Humans , Occupational Exposure/adverse effects , Occupational Exposure/analysisSubject(s)
Airway Obstruction/etiology , Bronchial Diseases/diagnostic imaging , Dyspnea/etiology , Histiocytosis, Non-Langerhans-Cell/diagnostic imaging , Tomography, X-Ray Computed , Tracheal Stenosis/diagnostic imaging , Adult , Airway Obstruction/diagnostic imaging , Bronchoscopy , Diagnosis, Differential , Dyspnea/diagnostic imaging , Humans , Male , RecurrenceABSTRACT
OBJECTIVE: To review the contrast-enhanced CT findings in surgically proven traumatic aortic injury (TAI). MATERIALS AND METHODS: We searched the trauma registries of three academic medical centres from 1994 to 2000 and found 34 patients with surgically proven TAI that received pre-operative contrast-enhanced chest CT. Two chest radiologists recorded by consensus the size and location of direct (pseudoaneurysm, intimal flap) and indirect (mediastinal haematoma) findings of TAI. The imaging findings were correlated with surgical reports. RESULTS: Direct findings of aortic injury (pseudoaneurysm or intimal flap) were seen on contrast enhanced CT in all patients and confirmed at surgery. Specifically, a pseudoaneurysm was seen in 33 (97%), presenting either as a focal bulge in 22 (65%) or as more diffuse aneurysmal enlargement in 11 (32%). An intimal flap was identified in 31 cases (91%). A periaortic haematoma was seen in 31 cases (91%). In the three patients without periaortic haematoma, the only indications of aortic injury were a focal pseudoaneurysm in two (6%) and an intimal flap in one (3%). CONCLUSION: In this series of surgically proven TAI, direct findings of aortic injury were seen in all cases. Aortic tear occurred without mediastinal haematoma in 9% (3/34) of patients.