ABSTRACT
INTRODUCTION: We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients. METHODS: Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil. RESULTS: Oral lesions, mainly pseudomembranous, were significantly related to higher levels of immunosuppression. Of 45 Candida isolates, 66.7% were C. albicans. Most of the isolates were susceptible to the antifungal drugs tested. CONCLUSIONS: Oral lesions were associated with higher immunosuppression levels. Lower susceptibility to antifungals by non-albicans isolates supports the importance of surveillance studies using susceptibility tests to aid in the treatment.
Subject(s)
AIDS-Related Opportunistic Infections/diagnosis , Antifungal Agents/pharmacology , Candida/drug effects , Candidiasis, Oral/diagnosis , AIDS-Related Opportunistic Infections/microbiology , Adult , Amphotericin B/pharmacology , Brazil , Candida/classification , Candida/isolation & purification , Candidiasis, Oral/microbiology , Drug Resistance, Microbial , Female , Fluconazole/pharmacology , Humans , Itraconazole/pharmacology , Male , Microbial Sensitivity Tests , Middle Aged , Mycological Typing Techniques , Young AdultABSTRACT
Abstract INTRODUCTION We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients. METHODS: Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil. RESULTS: Oral lesions, mainly pseudomembranous, were significantly related to higher levels of immunosuppression. Of 45 Candida isolates, 66.7% were C. albicans. Most of the isolates were susceptible to the antifungal drugs tested. CONCLUSIONS: Oral lesions were associated with higher immunosuppression levels. Lower susceptibility to antifungals by non-albicans isolates supports the importance of surveillance studies using susceptibility tests to aid in the treatment.
