ABSTRACT
Capnocytophaga canimorsus is a common Gram-negative anaerobic bacterium from the oral flora of dogs, typically transmitted to humans by dog bites. We report a case of C. canimorsus meningitis where there was (on presentation) no apparent predisposing risk factor and in whom we used 16S rRNA PCR gene sequencing to identify the pathogen quickly and to switch to appropriate antibiotic therapy. Physicians should be aware of potential C. canimorsus meningitis if conventional cerebrospinal fluid bacterial culture is negative but Gram staining identifies bacteria, especially in patients with a recent dog bite or known immunodeficiency.
Subject(s)
Gram-Negative Bacterial Infections/diagnosis , Meningitis, Bacterial/diagnosis , Meningitis, Bacterial/microbiology , RNA, Bacterial/analysis , RNA, Ribosomal, 16S/analysis , Animals , Capnocytophaga , Dogs , Gram-Negative Bacterial Infections/complications , Humans , Male , Middle Aged , Polymerase Chain ReactionSubject(s)
Pneumocephalus/diagnostic imaging , Skull Fractures/diagnostic imaging , Tomography, X-Ray Computed , Accidents, Traffic , Aged , Follow-Up Studies , Glasgow Coma Scale , Humans , Male , Maxillary Fractures/diagnostic imaging , Orbital Fractures/diagnostic imaging , Skull Fracture, Basilar/diagnostic imaging , Temporal Bone/diagnostic imaging , Temporal Bone/injuries , Zygomatic Fractures/diagnostic imagingABSTRACT
This is the first report that describes the clinical and histological findings in a patient suffering from pure congenital fibre type disproportion (CFTD), who had two biopsies with an interval of 16 years. Additionally, we compared the clinical signs and symptoms of the present case to those of 35 CFTD cases reviewed from the literature. From this we conclude that smallness of type I fibre diameter is not a characteristic feature during the course of pure CFTD. This suggests that CFTD is a time-locked diagnosis.