ABSTRACT
Mucoadhesive buccal patch is a promising dosage form for a successful oral drug delivery, which provides unique advantages for various applications such as treatment of periodontal disease and postdental surgery disorders. The aim of this study is to synthesize a novel multifunctional mucoadhesive buccal patch in a multilayer reservoir design for therapeutic applications. The patches were fabricated through simultaneous electrospinning of chitosan/poly(vinylalcohol) (PVA)/ibuprofen and electrospraying of phenylalanine amino acid nanotubes (PhNTs) containing metronidazole into the electrospun mats through a layer-by-layer process. An electrospun poly(caprolactone) (PCL) was used as an impermeable backing layer to protect the mucoadhesive component from tongue movement and drug loss. Buccal patches were characterized using scanning electron microscopy (SEM) and field emission scanning electron microscopy (FESEM) and also evaluated in terms of physicomechanical parameters such as pH, weight, thickness, tensile strength, folding endurance, and mucoadhesive properties. The swelling index of the patches was examined with respect to the PVA/chitosan ratio. The effect of genipin addition to the electrospinning solution was also studied on mucoadhesive and swelling properties. The cell viability of buccal patches was assessed by methylthiazolydiphenyl-tetrazolium bromide test on L929 fibroblast cell line. The patch with an optimal amount of mucoadhesive polymers (PVA/chitosan 80:20) and crosslinking agent (0.05 g) indicated an ideal hemostatic activity along with antibacterial properties against Streptococcus mutans bacteria. The synthesized multifunctional mucoadhesive patch with a novel composition and design has a great potential for oral therapeutic applications.
Subject(s)
Administration, Buccal , Drug Delivery Systems , Tissue Adhesives , Animals , Cheek , Chitosan , Cross-Linking Reagents , Ibuprofen/administration & dosage , Iridoids/chemistry , Metronidazole/administration & dosage , Metronidazole/chemistry , Mice , Microscopy, Electron, Scanning , Nanotubes , Phenylalanine/chemistry , Polyvinyl Alcohol , Streptococcus mutans/drug effects , Tensile StrengthABSTRACT
This paper deals with obtaining aromatherapic textiles via applying stimuli-responsive poly N-isopropyl acryl amide (PNIPAAm) /chitosan (PNCS) nano hydrogels containing cinnamon oil on cotton fabric and looks into the treated fabric characteristics as an antibacterial and temperature/pH responsive fabric. The semi-batch surfactant-free dispersion polymerization method was proposed to the synthesis of PNCS nano particles. The incorporation of modified ß -cyclodextrin ( ß -CD) into the PNCS nanohydrogel was performed in order to prepare a hydrophobic(cinnamon oil) carrier embedded in stimuli-responsive nanohydrogel. The ß -CD postloading process of cinnamon oil in to the hydrogel nano particles was performed via ultrasonic bath and exhaustion methods. The antibacterial activity of the treated fabrics at different temperatures demonstrated the preparing new functional bio-antibacterial fabrics with temperature responsiveness.
Subject(s)
Acrylic Resins/chemistry , Aromatherapy/methods , Hydrogels/chemistry , Nanocomposites/chemistry , Oils, Volatile/administration & dosage , Oils, Volatile/chemistry , Perfume/chemical synthesis , Cotton Fiber , Delayed-Action Preparations/administration & dosage , Delayed-Action Preparations/chemical synthesis , Materials Testing , Nanocomposites/ultrastructure , Surface Properties , TextilesABSTRACT
In this study, the effect of using folic acid on the in situ synthesis process of nanostructures has been investigated. Folic acid, as a biotemplate for synthesis of Cu2 O/ZnO, was used to improve the reducing and stabilizing the ability of cotton fabric and avoid agglomeration of the particles. Scanning electron microscopy images revealed that using folic acid caused the formation of particles with smaller sizes on the cotton fabric and X-ray diffraction confirmed the same crystalline pattern of nanoparticles in comparison with the previous synthesis process. The effect of using this biotemplate on different properties of treated fabrics including UV-protection effect, hydrophilicity, crease recovery angle, softness, thickness and mechanical properties has been evaluated. The folic acid had a great influence on UV-protection effect, in synthesis procedure, decreasing the droplet absorption time, bending length and improving the wrinkle resistance and mechanical properties. Interestingly, the higher tensile strength of the treated cotton fabrics proved the incorporation of nanoparticles into the cotton fibers. An in situ, green and rapid method can be provided by using folic acid for the synthesis of the nanostructures with controlled size.