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Safety, feasibility and preliminary efficacy of single agent combretastatin A1 diphosphate (OXi4503) in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes.
Cogle, Christopher R; Collins, Bradley; Turner, Daniel; Pettiford, Leslie C; Bossé, Raphael; Hawkins, Kimberly E; Beachamp, Zackary; Wise, Elizabeth; Cline, Christina; May, William S; Moreb, Jan S; Hsu, Jack; Hiemenz, John; Brown, Randall; Norkin, Maxim; Wingard, John R; Uckun, Fatih.
Br J Haematol ; 189(5): e211-e213, 2020 06.
Article in English | MEDLINE | ID: mdl-32236943

Subject(s)
Antineoplastic Agents/therapeutic use , Diphosphates/therapeutic use , Leukemia, Myeloid, Acute/drug therapy , Myelodysplastic Syndromes/drug therapy , Prodrugs/therapeutic use , Salvage Therapy , Stilbenes/therapeutic use , Adult , Aged , Antineoplastic Agents/administration & dosage , Antineoplastic Agents/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cytarabine/administration & dosage , Diphosphates/administration & dosage , Diphosphates/adverse effects , Drug Resistance, Neoplasm , Drug Synergism , Feasibility Studies , Female , Fibrin Fibrinogen Degradation Products/analysis , Hemorrhage/chemically induced , Humans , Leukemia, Myeloid, Acute/blood , Male , Middle Aged , Myelodysplastic Syndromes/blood , Prodrugs/administration & dosage , Prodrugs/adverse effects , Respiratory Distress Syndrome/chemically induced , Stilbenes/administration & dosage , Stilbenes/adverse effects , Treatment Outcome , Young Adult
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