Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline.

CLINICAL QUESTION: What are the benefits and harms of thyroid hormones for adults with subclinical hypothyroidism (SCH)? This guideline was triggered by a recent systematic review of randomised controlled trials, which could alter practice. CURRENT PRACTICE: Current guidelines tend to recommend thyroid hormones for adults with thyroid stimulating hormone (TSH) levels >10 mIU/L and for people with lower TSH values who are young, symptomatic, or have specific indications for prescribing. RECOMMENDATION: The guideline panel issues a strong recommendation against thyroid hormones in adults with SCH (elevated TSH levels and normal free T4 (thyroxine) levels). It does not apply to women who are trying to become pregnant or patients with TSH >20 mIU/L. It may not apply to patients with severe symptoms or young adults (such as those ≤30 years old). HOW THIS GUIDELINE WAS CREATED: A guideline panel including patients, clinicians, and methodologists produced this recommendation in adherence with standards for trustworthy guidelines using the GRADE approach. THE EVIDENCE: The systematic review included 21 trials with 2192 participants. For adults with SCH, thyroid hormones consistently demonstrate no clinically relevant benefits for quality of life or thyroid related symptoms, including depressive symptoms, fatigue, and body mass index (moderate to high quality evidence). Thyroid hormones may have little or no effect on cardiovascular events or mortality (low quality evidence), but harms were measured in only one trial with few events at two years' follow-up. UNDERSTANDING THE RECOMMENDATION: The panel concluded that almost all adults with SCH would not benefit from treatment with thyroid hormones. Other factors in the strong recommendation include the burden of lifelong management and uncertainty on potential harms. Instead, clinicians should monitor the progression or resolution of the thyroid dysfunction in these adults. Recommendations are made actionable for clinicians and their patients through visual overviews. These provide the relative and absolute benefits and harms of thyroid hormones in multilayered evidence summaries and decision aids available in MAGIC (https://app.magicapp.org/) to support shared decisions and adaptation of this guideline.

Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline

What are the benefits and harms of thyroid hormones for adults with subclinical hypothyroidism (SCH)? This guideline was triggered by a recent systematic review of randomised controlled trials, which could alter practice. Current guidelines tend to recommend thyroid hormones for adults with thyroid stimulating hormone (TSH) levels >10 mIU/L and for people with lower TSH values who are young, symptomatic, or have specific indications for prescribing. The guideline panel issues a strong recommendation against thyroid hormones in adults with SCH (elevated TSH levels and normal free T4 (thyroxine) levels). It does not apply to women who are trying tobecome pregnant or patients with TSH >20 mIU/L. It may not apply to patients with severe symptoms or youngadults (such as those ≤30 years old).

Safety of bevacizumab in patients with malignant gliomas: a systematic review.

Angiogenesis has recently become a major target for the development of new antineoplastic drugs. The most serious adverse events linked to angiogenesis inhibitors are venous or arterial thromboembolism and haemorrhage. Thus, there is need to define with more certainty the impact of these new drugs in terms of adverse effects in neurological patients. The aim of the study is to assess the risk of venous thromboembolism (VTE) and bleeding in patients with malignant gliomas treated with bevacizumab with or without concomitant anticoagulant therapy. A review of published literature was performed in Medline, from which 476 records were identified. A total of 27 full-text articles, including retrospective analyses, retrospective reviews, and open label trials, were assessed for eligibility. The investigated drugs included bevacizumab alone, bevacizumab plus chemotherapy with/without concomitant radiation therapy; only two articles dealt with bevacizumab in association with anticoagulant treatment. A total of 2,208 patients with malignant gliomas, were identified and included in the analysis. From data it appears that patients receiving bevacizumab had a major risk of developing VTE that increased when bevacizumab is associated with radio-chemotherapy (4.27 vs 7.46 %). Regarding bleeding, data showed that patients treated with anticoagulant had a significantly increased risk of severe central nervous system (CNS) bleeding compared to patients not receiving anticoagulant therapy (0.6 vs 8.2 %). The use of bevacizumab combined with chemo-radiotherapy seems to be associated with a higher risk for VTE compared to patients receiving antiangiogenic therapy alone. The associated use of anticoagulants and bevacizumab far increases the risk of developing CNS and non-CNS bleeding higher than grade 3, compared to patients receiving bevacizumab alone.

Search for a low-mass standard model Higgs boson in the ττ decay channel in pp collisions at sqrt[s]=1.96 TeV.

We report on a search for the standard model Higgs boson decaying into pairs of τ leptons in pp collisions produced by the Tevatron at sqrt[s]=1.96 TeV. The analyzed data sample was recorded by the CDFII detector and corresponds to an integrated luminosity of 6.0 fb(-1). The search is performed in the final state with one τ decaying leptonically and the second one identified through its semihadronic decay. Since no significant excess is observed, a 95% credibility level upper limit on the production cross section times branching ratio to the ττ final state is set for hypothetical Higgs boson masses between 100 and 150 GeV/c2. For a Higgs boson of 120 GeV/c2 the observed (expected) limit is 14.6 (15.3) the predicted value.

Precise measurement of the W-boson mass with the CDF II detector.

We have measured the W-boson mass M(W) using data corresponding to 2.2 fb(-1) of integrated luminosity collected in pp collisions at sqrt[s] = 1.96 TeV with the CDF II detector at the Fermilab Tevatron collider. Samples consisting of 470,126 W → eν candidates and 624,708 W → µν candidates yield the measurement M(W) = 80,387 ± 12(stat.) ± 15(syst.) = 80,387 ± 19 MeV/c2. This is the most precise measurement of the W-boson mass to date and significantly exceeds the precision of all previous measurements combined.

Measurements of the angular distributions in the decays B→K(*)µ(+)µ(-) at CDF.

We report an indirect search for nonstandard model physics using the flavor-changing neutral current decays B→K(*)µ(+)µ(-). We reconstruct the decays and measure their angular distributions, as a function of q(2)=M(µµ)(2)c(2), where M(µµ) is the dimuon mass, in pp¯ collisions at √s=1.96 TeV using a data sample corresponding to an integrated luminosity of 6.8 fb(-1). The transverse polarization asymmetry A(T)(2) and the time-reversal-odd charge-and-parity asymmetry A(im) are measured for the first time, together with the K* longitudinal polarization fraction F(L) and the muon forward-backward asymmetry A(FB) for the decays B(0)→K(*0)µ(+)µ(-) and B(+)→K(*+)µ(+)µ(-). The B→K*µ(+)µ(-) forward-backward asymmetry in the most sensitive kinematic regime, 1≤q(2)<6 GeV(2)/c(2), is measured to be A(FB)=0.29(-0.23)(+0.20)(stat)±0.07(syst), the most precise result to date. No deviations from the standard model predictions are observed.

Search for a Higgs boson in the diphoton final state in pp collisions at sqrt[s]=1.96 TeV.

A search for a narrow Higgs boson resonance in the diphoton mass spectrum is presented based on data corresponding to 7.0 fb{-1} of integrated luminosity from pp collisions at sqrt[s]=1.96 TeV collected by the CDF experiment. No evidence of such a resonance is observed, and upper limits are set on the cross section times branching ratio of the resonant state as a function of Higgs boson mass. The limits are interpreted in the context of the standard model and one fermiophobic benchmark model where the data exclude fermiophobic Higgs bosons with masses below 114 GeV/c{2} at a 95% Bayesian credibility level.

Search for B(s)(0) → µ+ µ- and B(0) → µ+ µ- decays with CDF II.

A search has been performed for B(s)(0) → µ+ µ- and B(0) → µ+ µ- decays using 7 fb(-1) of integrated luminosity collected by the CDF II detector at the Fermilab Tevatron collider. The observed number of B(0) candidates is consistent with background-only expectations and yields an upper limit on the branching fraction of B(B(0) → µ+ µ-) < 6.0 × 10(-9) at 95% confidence level. We observe an excess of B(s)(0) candidates. The probability that the background processes alone could produce such an excess or larger is 0.27%. The probability that the combination of background and the expected standard model rate of B(s)(0) → µ+ µ- could produce such an excess or larger is 1.9%. These data are used to determine B(B(s)(0)→ µ+ µ-) = (1.8(-0.9) (+1.1)) × 10(-8) and provide an upper limit of B(B(s)(0) → µ+ µ-) < 4.0 × 10(-8) at 95% confidence level.

Search for New T' particles in final states with large jet multiplicities and missing transverse energy in p p collisions at sqrt[s] = 1.96 TeV.

We present a search for a new particle T' decaying to a top quark via T' → t + X, where X goes undetected. We use a data sample corresponding to 5.7 fb(-1) of integrated luminosity of p p collisions with sqrt[s] = 1.96 TeV, collected at Fermilab Tevatron by the CDF II detector. Our search for pair production of T' is focused on the hadronic decay channel, pp → T'T' → tt + XX → bqq b qq + XX. We interpret our results in terms of a model where T' is an exotic fourth generation quark and X is a dark matter particle. The data are consistent with standard model expectations. We set a limit on the generic production of T'T' → tt + XX, excluding the fourth generation exotic quarks T' at 95% confidence level up to m(T') = 400 GeV/c(2) for m(X) ≤ 70 GeV/c(2).

Observation of the baryonic flavor-changing neutral current decay Λb(0)â†’Λµ+µ-.

We report the first observation of the baryonic flavor-changing neutral current decay Λ(b)(0)â†’Λµ(+)µ(-) with 24 signal events and a statistical significance of 5.8 Gaussian standard deviations. This measurement uses a pp collisions data sample corresponding to 6.8 fb(-1) at √s = 1.96 TeV collected by the CDF II detector at the Tevatron collider. The total and differential branching ratios for Λ(b)(0)â†’Λµ(+)µ(-) are measured. We find B(Λ(b)(0)â†’Λµ(+)µ(-))=[1.73 ± 0.42(stat) ± (syst)] × 10(-6). We also report the first measurement of the differential branching ratio of B(s)(0)→ϕµ(+)µ(-), using 49 signal events. In addition, we report branching ratios for B(+)→K(+)µ(+)µ(-), B(0)→K(0)µ(+)µ(-), and B→K(*)(892)µ(+)µ(-) decays.

Top-quark mass measurement using events with missing transverse energy and jets at CDF.

We present a measurement of the top-quark mass using a sample of t ̄t events in 5.7 fb(-1) of integrated luminosity from p ̄p collisions at the Fermilab Tevatron with √s=1.96 TeV and collected by the CDF II Detector. We select events having large missing transverse energy, and four, five, or six jets with at least one jet tagged as coming from a b quark, and reject events with identified charged leptons. This analysis considers events from the semileptonic t ̄t decay channel, including events that contain tau leptons. The measurement is based on a multidimensional template method. We fit the data to signal templates of varying top-quark masses and background templates, and measure a top-quark mass of M(top)=172.32±2.4(stat)±1.0(syst) GeV/c(2).

Search for new physics in high pT like-sign dilepton events at CDF II.

We present a search for new physics in events with two high pT leptons of the same electric charge, using data with an integrated luminosity of 6.1 fb(-1). The observed data are consistent with standard model predictions. We set 95% C.L. lower limits on the mass of doubly charged scalars decaying to like-sign dileptons, m(H±±) > 190-245 GeV/c(2), assuming 100% BR to ee, µµ or eµ.

Observation of the Ξ(b)(0) baryon.

The observation of the bottom, strange baryon Ξ(b)(0) through the decay chain Ξ(b)(0)→Ξ(c)(+)π-, where ΞΞ(c)(+)→Ξ- π+ π+, Ξ-→Λπ-, and Λ→pπ-, is reported by using data corresponding to an integrated luminosity of 4.2 fb(-1) from pp collisions at square root(s)=1.96 TeV recorded with the Collider Detector at Fermilab. A signal of 25.3(-5.4)(+5.6) candidates is observed whose probability of arising from a background fluctuation is 3.6×10(-12), corresponding to 6.8 gaussian standard deviations. The Ξ(b)(0) mass is measured to be 5787.8±5.0(stat)±1.3(syst) MeV/c2. In addition, the Ξ(b)- baryon is observed through the process Ξ(b)-→Ξ(c)(0)π-, where Ξ(c)(0)→Ξ- π+, Ξ-→Λπ-, and Λ→pπ-.

Measurement of the cross section for prompt isolated diphoton production in pp collisions at square root(s) = 1.96 TeV.

This Letter reports a measurement of the cross section of prompt isolated photon pair production in pp collisions at a total energy square root(s)=1.96 TeV using data of 5.36 fb(-1) integrated luminosity collected with the CDF II detector at the Fermilab Tevatron. The measured cross section, differential in basic kinematic variables, is compared with three perturbative QCD predictions, a leading order parton shower calculation and two next-to-leading order calculations. The next-to-leading order calculations reproduce most aspects of the data. By including photon radiation from quarks before and after hard scattering, the parton shower prediction becomes competitive with the next-to-leading order predictions.

Search for a very light CP-odd Higgs boson in top quark decays from pp collisions at sqrt(s)]=1.96 TeV.

We present the results of a search for a very light CP-odd Higgs boson a(1)(0) originating from top quark decays t → H(±)b → W(±(*)) a(1)(0)b, and subsequently decaying into τ+ τ-. Using a data sample corresponding to an integrated luminosity of 2.7 fb(-1) collected by the CDF II detector in pp collisions at 1.96 TeV, we perform a search for events containing a lepton, three or more jets, and an additional isolated track with transverse momentum in the range 3 to 20 GeV/c. Observed events are consistent with background sources, and 95% C.L. limits are set on the branching ratio of t → H(±)b for various masses of H(±) and a(1)(0).

First search for multijet resonances in sqrt(s) = 1.96 TeV pp collisions.

We present the first model independent search for three-jet hadronic resonances within multijet events in sqrt(s) = 1.96 TeV pp collisions at the Fermilab Tevatron using the CDF II detector. Pair production of supersymmetric gluinos and squarks with hadronic R-parity violating decays is employed as an example of a new physics benchmark for this signature. Selection criteria based on the kinematic properties of an ensemble of jet combinations within each event help to extract signal from copious QCD background. No significant excess outside the top quark mass window is observed in data with an integrated luminosity of 3.2 fb(-1). We place 95% confidence level limits on the production cross section σ(pp → XX')×BR(gg → 3 jet + 3 jet) where X, X' = g, q, or q, with q, q → g + jet, as a function of gluino mass, in the range of 77 GeV/c2 to 240 GeV/c2.

Limits on anomalous trilinear gauge couplings in Zγ events from pp¯ collisions at √s=1.96 TeV.

Using Zγ candidate events collected by the CDF detector at the Tevatron Collider, we search for potential anomalous (non-standard-model) couplings between the Z boson and the photon. Zγ couplings vanish at tree level and are heavily suppressed at higher orders; hence any evidence of couplings indicates new physics. Measurements are performed using data corresponding to an integrated luminosity of 4.9 fb(-1) in the Z→νν¯ decay channel and 5.1 fb(-1) in the Z→l(+)l(-) (l=µ, e) decay channels. The combination of these measurements provides the most stringent limits to date on Zγ trilinear gauge couplings. Using an energy scale of Λ=1.5 TeV to allow for a direct comparison with previous measurements, we find limits on the CP-conserving parameters that describe Zγ couplings to be |h(3)(γ,Z)|<0.022 and |h(4)(γ,Z)|<0.0009. These results are consistent with standard model predictions.

Search for new dielectron resonances and Randall-Sundrum gravitons at the collider detector at Fermilab.

A search for new dielectron-mass resonances using data recorded by the CDF II detector and corresponding to an integrated luminosity of 5.7 fb(-1) is presented. No significant excess over the expected standard model prediction is observed. In this data set, an event with the highest dielectron mass ever observed (960 GeV/c(2)) was recorded. The results are interpreted in the Randall-Sundrum (RS) model. Combined with the 5.4 fb(-1) diphoton analysis, the RS-graviton lower-mass limit for the coupling k/M¯(Pl)=0.1 is 1058 GeV/c(2), making it the strongest limit to date.

First measurement of the angular coefficients of Drell-Yan e(+)e(-) pairs in the Z mass region from pp¯ collisions at √s=1.96 TeV.

We report on the first measurement of the angular distributions of final state electrons in pp¯ → γ*/Z → e(+)e(-) + X events produced in the Z boson mass region at √s1.96 TeV. The data sample collected by the CDF II detector for this result corresponds to 2.1 fb(-1) of integrated luminosity. The angular distributions are studied as a function of the transverse momentum of the electron-positron pair and show good agreement with the Lam-Tung relation, consistent with a spin-1 description of the gluon, and demonstrate that, at high values of the transverse momentum, Z bosons are produced via quark-antiquark annihilation and quark-gluon Compton processes.

Invariant mass distribution of jet pairs produced in association with a W boson in pp collisions at sqrt[s]=1.96 TeV.

We report a study of the invariant mass distribution of jet pairs produced in association with a W boson using data collected with the CDF detector which correspond to an integrated luminosity of 4.3 fb(-1). The observed distribution has an excess in the 120-160 GeV/c(2) mass range which is not described by current theoretical predictions within the statistical and systematic uncertainties. In this Letter, we report studies of the properties of this excess.