1.
IARC Sci Publ
; (125): 229-44, 1994.
Article
in English
| MEDLINE
| ID: mdl-7806315
Subject(s)
Carcinogens/metabolism , Carcinogens/toxicity , DNA Adducts/biosynthesis , DNA/drug effects , DNA/metabolism , Environmental Pollutants/metabolism , Environmental Pollutants/toxicity , Mutagens/metabolism , Mutagens/toxicity , Nitro Compounds/metabolism , Nitro Compounds/toxicity , Polycyclic Compounds/metabolism , Polycyclic Compounds/toxicity , Animals , Carcinogens/pharmacokinetics , Environmental Pollutants/pharmacokinetics , Humans , Mutagens/pharmacokinetics , Nitro Compounds/pharmacokinetics , Polycyclic Compounds/pharmacokinetics
2.
IARC Sci Publ
; (89): 175-80, 1988.
Article
in English
| MEDLINE
| ID: mdl-3198200
ABSTRACT
A linear relationship was observed between the administered dose and DNA adduct levels in the livers and bladders of BALB/c mice fed the carcinogen, 2-acetylaminofluorene (2-AAF), continuously for one month. A similar linear correlation was found between the probit of the liver tumour incidence and the log of the liver DNA adduct levels; however, because there is a no-observable-effect level for bladder tumour induction, the relationship between the probit of the bladder tumour incidence and bladder DNA adduct levels was not linear. These data suggest that the relationship between DNA adduct formation and tumour incidence may be tissue specific.