[Human sera as a source of anti-OF antibodies for the typing of group-A streptococci]. / Chelovecheskie syvorotki kak istochnik anti-OF-antitel dlia tipirovaniia streptokokkov gruppy A.

For typing group A streptococci anti-OF rabbit or guinea-pig sera are usually used in the Al-apoproteinase neutralization test. Still in view of the fact that the technology of the preparation of anti-OF sera with the use of laboratory animals is labor consuming and demands great expense, the use of human donor sera is expedient. A good basis for it is created by a wide spread of streptococcal diseases. At the same time it is impossible to provide a full set of anti-OF sera by the efforts of one laboratory in a single geographical region due to the absence of some types in a given population; for this reason the international bank of sera from donors having antibodies to OF(+) of group A streptococci has been created.

[The OF characteristics of streptococci group A and immunity to streptococcal infection based on the results of OF and anti-OF tests]. / OF-kharakteristika streptokokkov gruppy A i immunitet k streptokokkovoi infektsii po rezul'tatam OF- i anti-OF-testov.

The influence of the OF activity of group A streptococci on their specific pathogenic properties has been shown, which is manifested by increased virulence of these streptococci for children of younger age groups and by a two times higher isolation rate of OF+ strains in tonsillitis than in scarlet fever. The possibility of the indirect evaluation of the content of anti-M-antibodies by the results of the anti-OF test has been revealed, which permits using this test instead of the bactericidal test, more complicated, in the study of immunity to infection induced by group A OF+ streptococci. Among the main methods of laboratory support of epidemiological surveillance on streptococcal infection, the introduction of the highly discriminating OF typing and the anti-OF test into practical use is recommended.

[OF- and anti-OF test systems in microbiological and epidemiologic practice]. / OF- i anti-OF-test-sistemy v mikrobiologicheskoi i épidemiologi- cheskoi praktike.

The possibilities of group A streptococcus typing are opened up, the microorganism being the causative agent of a highly prevalent infectious disease. The first Soviet-made kit of immune anti-OF sera for typing OF-positive group A streptococci have been prepared. A possibility of preparing a human donor kit of anti-OF sera is discussed.