The use of nimodipine (Nimotop-Bayer) in patients with chronic ischemic cerebral vasculopathies. Twenty-eight case reports.

Nimodipine therapy (30 mg x 3/die) was commenced in twenty-eight patients affected by chronic ischemic cerebral vasculopathies and continued for the 90 days in order to evaluate drug efficacy. Clinical controls were carried out 4, 8 and 12 weeks after the start of therapy using Doppler, ultrasound and neurological tests (the letter based on the SCAG neurological scale). Hemodynamic and hematochemical parameters were also monitored and controlled.

[A point about obstructive non-neoplastic pathology of the duodeno-biliary-pancreatic junction]. / Il punto sulla patologia ostruente non neoplastica del giunto duodeno-bilio-pancreatico.

Various benign pathological conditions of Oddi's sphincter may give origin to clinical manifestations due to hindrances to biliary flow into the duodenum; the hypertonic dyskinesia, proper, odditis and fibrosclerotic dystrophies. Such forms develop very big problems from a diagnostic and therapeutical point of view, even if an adequate therapy permits in most cases to reach definite results. Therapy in inflammatory forms (odditis) must be first of all of medical type; only when these are changing into fibrosclerotic forms or are manifest in an acute way it is meet to proceed surgically on the sphincter. The action on the sphincter, either by means of endoscopy or surgery, is performed with caution in the forms of hypertonic dyskinesia (only when such forms are going on and have had a long duration, or even resistant to any pharmacological therapy) because of the high percentage of painful recurrences. The cutting of Oddi's sphincter is on the contrary the first therapeutical choice in the fibrosclerotic forms, with immediate success on the symptoms and the results in the long run are optimal.

[384 papillosphincterostomy operations. Indications, technic, results and long-term control]. / 384 interventi di papillosfinterostomia. Indicazioni, tecnica, risultati e controlli a distanza.

The immediate and long-term results of 384 papillosphincterostomy operations carried out between 1969 and 1979 are presented and discussed. After defining the operation exactly, indications for it are illustrated, i.e.: VP lithiasis, fibrosclerotic odditis, Oddian functional pathology and other pathologies. Special attention is paid to diagnostic techniques. After commenting on surgical techniques, the results obtained in the immediate postoperative course are examined and it is pointed out that complications specific to the type of operation occurred in 1.5% of cases, with a mortality of 1.3% and an incidence of acute pancreatitis of 0.3% (3 cases of which 1 fatal). 162 patients (42%) were followed up between 10 years and 3 months after operation. Follow-up showed the absence of late after-effects and as well as the advantages of effecting an extensive incisura at the Oddian sphincter.