Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters











Database
Language
Publication year range
1.
Pediatr Hematol Oncol ; 39(1): 62-67, 2022 Feb.
Article in English | MEDLINE | ID: mdl-33988076

ABSTRACT

This case report presents the first reported pediatric case of primary classical nodular sclerosing Hodgkin Lymphoma (HL) with pineal gland involvement, presenting without CNS symptoms, which completely resolved after 2 cycles of chemotherapy. The 12 year-old male first presented with a right inguinal mass and external iliac lymphadenopathy accompanied by B symptoms. He was diagnosed with stage IV B classical HL, and as part of the staging work-up, a full-body PET/CT scan was performed. In addition to the right inguinal mass, the PET/CT demonstrated increased FDG uptake at the pineal gland along with level II lymph nodes. The patient was treated with ABVE-PC chemotherapy (Doxorubicin, Bleomycin, Vincristine, Etoposide, Prednisone, and Cyclophosphamide) as per standard arm of AHOD1331 COG protocol for newly diagnosed high-risk HL patients, which resolved the pineal mass after 2 cycles without requiring radiation therapy. Following 5 cycles, a full-body PET/CT showed no brain or neck activity, along with decreased size and activity of the right groin mass. To our knowledge, there are no other documented cases of primary HL with specific pineal involvement, and no cases that lack CNS symptoms altogether like this one did. Additionally, this is the third published pediatric case of primary CNS-HL, both of the previous cases were treated with radiotherapy and presented with CNS symptoms. Thus, this case demonstrates the importance of ordering a full-body PET/CT as part of the initial HL work-up and provides evidence that chemotherapy alone is a treatment option for some patients with primary intracranial HL.


Subject(s)
Hodgkin Disease , Pineal Gland , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Child , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Etoposide/therapeutic use , Hodgkin Disease/diagnostic imaging , Hodgkin Disease/drug therapy , Humans , Male , Pineal Gland/diagnostic imaging , Positron Emission Tomography Computed Tomography , Prednisone/therapeutic use , Treatment Outcome , Vinblastine/therapeutic use , Vincristine/therapeutic use
3.
AJR Am J Roentgenol ; 195(3 Suppl): S9-11, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20729413

ABSTRACT

The educational objectives for this self-assessment module are for the participant to exercise, self-assess, and improve his or her understanding of the hyperintensity of the basal ganglia and cortex on FLAIR and diffusion-weighted imaging and the key imaging characteristics of various causes of the hyperintensity of the basal ganglia and cortex.


Subject(s)
Basal Ganglia/pathology , Brain Diseases/diagnosis , Magnetic Resonance Imaging/methods , Brain Diseases/etiology , Brain Diseases/pathology , Diagnosis, Differential , Diffusion Magnetic Resonance Imaging , Humans , Medical History Taking
SELECTION OF CITATIONS
SEARCH DETAIL