Cardiac autonomic regulation during submaximal exercise in women with fibromyalgia.

Fibromyalgia (FM) patients present impaired cardiac autonomic regulation during maximal exercise; however, it is unknown whether these alterations also manifest during submaximal exercise. The aim of this study was to compare the on-transient heart rate (HR) response and HR variability during a constant-load submaximal cycling exercise between FM and control (CON) women. Ten women with FM (age: 45.2±9.3 years) and 10 age-matched CON women (age: 48.4±6.1 years) performed a 15-min cycling exercise, with the work rate fixed at 50% of the individual peak power output attained in a maximal graded exercise test. The time intervals between consecutive heartbeats were recorded regularly during the exercise for subsequent analysis of on-transient HR response and HR variability indices. The on-transient HR time constant was similar (P=0.83) between the FM (41.0±14.1 sec) and CON (42.2±10.4 sec). During the 5-10 and 10-15 min of exercise, HR variability indices indicating sympathetic and parasympathetic activities were similar (P>0.05) between FM and CON groups. In conclusion, women with FM presented a normal cardiac autonomic response to submaximal cycling exercise. These findings have clinical relevance, as submaximal exercises are commonly prescribed for FM patients.

Time-Motion and Technical-Tactical Aspects of Glory World Series Matches in the Male Middle-Heavy-Weight Category.

PURPOSE: To characterize the time structure of K1 kickboxing matches of Glory World Series (Glory) and to determine potential differences between winners and losers. METHODS: Seventeen matches of Glory 2019 (17 first rounds, 13 second rounds, and 8 third rounds) were video-analyzed to quantify (1) the time expended in high- and low-intensity activity and pauses, (2) the number and pattern of attacks, and (3) the number of effective attacks. Fighters were professional male athletes (age 27.9 [2.7] y) of the middle-weight category (85 kg). The number and the pattern of attacks and the number of effective attacks were compared between winners and losers. RESULTS: The mean times expended in high- and low-intensity activity and pauses were 234.6 (133.9) seconds, 97.4 (60.1) seconds, and 36.0 (19.9) seconds, respectively, resulting in an effort-to-pause ratio of ∼1.8:1. Compared with losers, winners presented (1) a greater number of attacks in the second round (P = .004) and entire match (P = .009), (2) a greater number of attacks containing 3 attacks in sequence in the second round (P = .001) and attacks containing >3 attacks in the third round (P = .049), and (3) a greater number of effective attacks in the second round (P = .011) and entire match (P = .008). CONCLUSIONS: The findings of the present study indicate that K1 kickboxing in Glory matches presents a ∼1.8:1 effort-to-pause ratio and that winners perform more attacks, effective attacks, and attacks in sequence. These data provide useful insights to improve the training specificity of kickboxing athletes.

Effects of Acute Ingestion of Guarana (Paullinia Cupana) on Soccer Player Performance: A Randomized, Cross-over, Placebo-Controlled Study.

OBJECTIVE: To investigate the acute effects of ingesting a beverage containing guarana (Paullinia cupana) seed powder on performance during field tests related to physical capacities that are determinants of soccer performance, such as lower limb power, sprint, agility, and the capacity to carry out intermittent exercise. METHODS: The study was conducted using a randomized, crossover, and counterbalanced design, with a beverage containing guarana or placebo administered in a double-blind manner. Twenty-seven under-17 soccer players of a professional soccer club performed a battery of tests 60 min after the ingestion of guarana (3 g of the fruit seed powder) or placebo. Trials were performed with a 7-day washout period. The battery of tests included a countermovement jump test, sprints of 10 and 20 m, an Illinois agility test, and a Yo-Yo Intermittent Recovery Test level 1 (YYIR1). RESULTS: Guarana ingestion did not improve countermovement jump, sprints, or agility (p > 0.05). However, guarana ingestion increased the distance covered in the YYIR1, compared with placebo ingestion (p = 0.01). CONCLUSION: Acute ingestion of guarana improves the capacity to perform intermittent exercise in soccer players but seems to be ineffective to improve lower limb power, sprint, and agility.

The blood serum metabolome profile after different phases of a 4-km cycling time trial: Secondary analysis of a randomized controlled trial.

It has been assumed that exercise intensity variation throughout a cycling time trial (TT) occurs in alignment of various metabolic changes to prevent premature task failure. However, this assumption is based on target metabolite responses, which limits our understanding of the complex interconnection of metabolic responses during exercise. The current study characterized the metabolomic profile, an untargeted metabolic analysis, after specific phases of a cycling 4-km TT. Eleven male cyclists performed three separated TTs in a crossover counterbalanced design, which were interrupted at the end of the fast-start (FS, 600 ± 205 m), even-pace (EP, 3600 ± 190 m), or end-spurt (ES, 4000 m) phases. Blood samples were taken before any exercise and 5 min after exercise cessation, and the metabolomic profile characterization was performed using Nuclear Magnetic Resonance metabolomics. Power output (PO) was also continually recorded. There were higher PO values during the FS and ES compared to the EP (all p < 0.05), which were accompanied by distinct metabolomic profiles. FS showed high metabolite expression in TCA cycle and its related pathways (e.g., glutamate, citric acid, and valine metabolism); whereas, the EP elicited changes associated with antioxidant effects and oxygen delivery adjustment. Finally, ES was related to pathways involved in NAD turnover and serotonin metabolism. These findings suggest that the specific phases of a cycling TT are accompanied by distinct metabolomic profiles, providing novel insights regarding the relevance of specific metabolic pathways on the process of exercise intensity regulation.

Caffeine, but Not Creatine, Improves Anaerobic Power Without Altering Anaerobic Capacity in Healthy Men During a Wingate Anaerobic Test.

There is a lack of evidence on the additional benefits of combining caffeine (CAF) and creatine (CRE) supplementation on anaerobic power and capacity. Thus, the aim of the present study was to test the effects of combined and isolated supplementation of CAF and CRE on anaerobic power and capacity. Twenty-four healthy men performed a baseline Wingate anaerobic test and were then allocated into a CRE (n = 12) or placebo (PLA; n = 12) group. The CRE group ingested 20 g/day of CRE for 8 days, while the PLA group ingested 20 g/day of maltodextrin for the same period. On the sixth and eighth days of the loading period, both groups performed a Wingate anaerobic test 1 hr after either CAF (5 mg/kg of body mass; CRE + CAF and PLA + CAF conditions) or PLA (5 mg/kg of body mass of cellulose; CRE + PLA and PLA + PLA conditions) ingestion. After the loading period, changes in body mass were greater (p < .05) in the CRE (+0.87 ± 0.23 kg) than in the PLA group (+0.13 ± 0.27 kg). In both groups, peak power was higher (p = .01) in the CAF (1,033.4 ± 209.3 W) than in the PLA trial (1,003.3 ± 204.4 W), but mean power was not different between PLA and CAF trials (p > .05). In conclusion, CAF, but not CRE ingestion, increases anaerobic power. Conversely, neither CRE nor CAF has an effect on anaerobic capacity.

Use of Inter-Effort Recovery Hypoxia as a New Approach to Improve Anaerobic Capacity and Time to Exhaustion.

Putti, Germano Marcolino, Gabriel Peinado Costa, Matheus Silva Norberto, Carlos Dellavechia de Carvalho, Rômulo Cássio de Moraes Bertuzzi, and Marcelo Papoti. Use of inter-effort recovery hypoxia as a new approach to improve anaerobic capacity and time to exhaustion. High Alt Med Biol. 25:68-76, 2024. Background: Although adding hypoxia to high-intensity training may offer some benefits, a significant problem of this training model is the diminished quality of the training session when performing efforts in hypoxia. The purpose of this study was to investigate the effects of training and tapering combined with inter-effort recovery hypoxia (IEH) on anaerobic capacity, as estimated by alternative maximum accumulated oxygen deficit (MAODALT) and time to exhaustion (TTE). Methods: Twenty-four amateur runners performed, for 5 weeks, 3 sessions per week of training consisted of ten 1-minute bouts at 120% (weeks 1-3) and 130% (weeks 4 and 5) of maximum velocity (VMAX) obtained in graded exercise test, separated by a 2-minute interval in IEH (IEH, n = 11, FIO2 = 0.136) or normoxia (NOR, n = 13, fraction of inspired oxygen = 0.209). Before training, after training, and after 1 week of tapering, a graded exercise test and a maximal effort to exhaustion at 120% of VMAX were performed to determine TTE and MAODALT. The results were analyzed using generalized linear mixed models, and a clinical analysis was also realized by the smallest worthwhile change. Results: MAODALT increased only in IEH after training (0.8 ± 0.5 eq.lO2) and tapering (0.8 ± 0.5 eq.lO2), with time x group interaction. TTE increased for the pooled groups after taper (23 ± 11 seconds) and only for IEH alone (29 ± 16 seconds). Clinical analysis revealed a small size increase for NOR and a moderate size increase for IEH. Conclusions: Although the effects should be investigated in other populations, it can be concluded that IEH is a promising model for improving anaerobic performance and capacity. World Health Organization Universal Trial Number: U1111-1295-9954. University's ethics committee registration number: CAAE: 32220020.0.0000.5659.

Can plyometric training change the pacing behaviour during 10-km running?

The effects of plyometric training (PT) on middle- and long-distance running performances are well established. However, its influence on pacing behaviour is still unclear. The aim of this study was to evaluate the effects of PT on pacing behaviour. In addition, verify whether the adaptations induced by PT would change ratings of perceived exertion (RPE) and/or affective feelings during the race. Twenty-eight male runners were assigned to two groups: control (C) and PT. PT held two weekly PT sessions for eight weeks. Drop jump (DJ) performance, 10-km running performance, pacing behaviour, RPE and affective feelings, VO2peak, ventilatory thresholds (VT1 and VT2), peak treadmill speed (PTS), and running economy (RE) were measured. For group comparisons, a mixed model analysis for repeated measures, effect size (ES) and 90% confidence interval (90% CI) were calculated for all dependent variables. Significant differences pre-to-post was observed for PT group in DP (7.2%; p ≤ 0.01; ES = 0.56 (0.28-0.85)) and RE (4.5%; p ≤ 0.05; ES = -0.52 ((-0.73 to -0.31)) without changes in pacing behaviour. While PT was effective for improving DJ and RE, there is no evidence that pacing behaviour, RPE or affective feelings are directly affected by these adaptations during a 10-km time trial run.

Can Hypoxia Alter the Anaerobic Capacity Measured by a Single Exhaustive Exercise?

The present study aimed to compare the MAODALT in situations of hypoxia and normoxia to confirm the method validity. Seventeen healthy and physically active men participated in this study, aged 25.2±3.2 years. All participants underwent four days of evaluation. The first day was performed a body composition test, an incremental test to exhaustion to determine the maximum oxygen uptake, familiarizing the hypoxia (H) and normoxia (N) situation and the equipment used. On the second, third and fourth days, supramaximal efforts were performed until exhaustion at 110% of maximum oxygen uptake, in a situation of hypoxia (FIO2=14.0%) and normoxia (FIO2=20.9%). The anaerobic capacity was considered the sum of energy supply of the alactic and lactic systens. The absolute or relative anaerobic capacity values were not different (H=3.9±1.1 L, N=3.8±0.9 L, p=0.69), similarly no differences were found for the alactic contribution (H=1.7±0.5 L, N=1.5±0.5 L, p=0.30) and lactic contribution (H=2.3±0.9 L, N=2.3±0.7 L, p=0.85). It can be concluded that the anaerobic capacity measured by a single exhaustive effort is not altered by hypoxia.

Caffeine reverts loss of muscular performance during the early-follicular phase in resistance-trained naturally menstruating women.

The aim of this study was to compare the effects of caffeine ingestion on muscular performance during the early-follicular and mid-luteal phases of the menstrual cycle. Fourteen resistance-trained naturally menstruating women performed countermovement jump (CMJ), maximal voluntary isometric contraction (MVIC), one-repetition maximum (1-RM), and repetitions-to-failure (RF) at 80% of 1-RM in the half-squat exercise, in early-follicular and mid-luteal phases, after placebo or caffeine ingestion. The early-follicular and mid-luteal phases were identified via calendar-based counting method. The MVIC was lower in the early-follicular than mid-luteal phase (-6.2 ± 15.2 N, p < 0.05) and higher with caffeine than placebo ingestion regardless of the menstrual cycle phase (+16.8 ± 26.7 N, p < 0.05). The magnitude of gains (supplement x phase interaction, p < 0.026) in 1-RM, CMJ, and RF with caffeine ingestion was higher in the early-follicular (+16.6 ± 7.1 kg, +2.5 ± 1.6 cm, and +4.5 ± 2.6 repetitions, respectively) than in the mid-luteal phase (+7.7 ± 4.8 kg, +1.5 ± 2.0 cm, and +2.4 ± 3.1 repetitions, respectively). In conclusion, the greater ergogenic effect of caffeine during the early-follicular phase supports its use to mitigate the decline in muscular performance in this phase of the menstrual cycle.

Caffeine ingestion increases endurance performance of trained male cyclists when riding against a virtual opponent without altering muscle fatigue.

PURPOSE: Caffeine improves cycling time trial (TT) performance; however, it is unknown whether caffeine is ergogenic when competing against other riders. The aim of this study was to investigate whether caffeine improves performance during a 4-km cycling TT when riding against a virtual opponent, and whether it is associated with increased muscle activation and at the expense of greater end-exercise central and peripheral fatigue. METHODS: Using a randomized, crossover, and double-blind design, eleven well-trained cyclists completed a 4-km cycling TT alone without supplementation (CON), or against a virtual opponent after ingestion of placebo (OP-PLA) or caffeine (5 mg.kg-1, OP-CAF). Central and peripheral fatigue were quantified via the pre- to post-exercise decrease in voluntary activation and potentiated twitch force, respectively. Muscle activation was continually measured during the trial via electromyography activity. RESULTS: Compared to CON, OP-PLA improved 4-km cycling TT performance (P = 0.018), and OP-CAF further improved performance when compared to OP-PLA (P = 0.050). Muscle activation was higher in OP-PLA and OP-CAF than in CON throughout the trial (P = 0.003). The pre- to post-exercise reductions in voluntary activation and potentiated twitch force were, however, similar between experimental conditions (P > 0.05). Compared to CON, OP-PLA increased the rating of perceived exertion during the first 2 km, but caffeine blunted this increase with no difference between the OP-CAF and CON conditions. CONCLUSIONS: Caffeine is ergogenic when riding against a virtual opponent, but this is not due to greater muscle activation or at the expense of greater end-exercise central or peripheral fatigue.

Effects of air pollution exposure on inflammatory and endurance performance in recreationally trained cyclists adapted to traffic-related air pollution.

The aim of the present study was to analyze the effects of traffic-related air pollution (TRAP) on markers of inflammatory, neuroplasticity, and endurance performance-related parameters in recreationally trained cyclists who were adapted to TRAP during a 50-km cycling time trial (50-km cycling TT). Ten male cyclists performed a 50-km cycling TT inside an environmental chamber located in downtown Sao Paulo (Brazil), under TRAP or filtered air conditions. Blood samples were obtained before and after the 50-km cycling TT to measure markers of inflammatory [interleukin-6 (IL-6), C-reactive protein (CRP), interleukin-10 (IL-10), intercellular adhesion molecule-1 (ICAM-1)] and neuroplasticity [brain-derived neurotrophic factor (BDNF)]. Rating of perceived exertion (RPE), heart rate (HR), and power output (PO) were measured throughout the 50-km cycling TT. There were no significant differences between experimental conditions for responses of IL-6, CRP, and IL-10 (P > 0.05). When compared with exercise-induced changes in filtered air condition, TRAP provoked greater exercise-induced increase in BDNF levels (TRAP = 3.3 ± 2.4-fold change; Filtered = 1.3 ± 0.5-fold change; P = 0.04) and lower exercise-induced increase in ICAM-1 (Filtered = 1.1 ± 0.1-fold change; TRAP = 1.0 ± 0.1-fold change; P = 0.01). The endurance performance-related parameters (RPE, HR, PO, and time to complete the 50-km cycling TT) were not different between TRAP and filtered air conditions (P > 0.05). These findings suggest that the potential negative impacts of exposure to pollution on inflammatory, neuroplasticity, and performance-related parameters do not occur in recreationally trained cyclists who are adapted to TRAP.

Caffeine alters the breathing pattern during high-intensity whole-body exercise in healthy men.

PURPOSE: The current study investigated the effect of caffeine on the breathing pattern during a high-intensity whole-body exercise. METHODS: Using a randomized, crossover, counterbalanced, and double-blind design, twelve healthy men ingested either 5 mg.kg-1 of caffeine or cellulose (placebo) one hour before performing a high-intensity whole-body exercise (i.e., work rate corresponding to 80% of the difference between the gas exchange threshold and maximal oxygen uptake) until the limit of tolerance. Ventilatory and metabolic responses were recorded throughout the trial and at task failure. RESULTS: Caffeine ingestion increased time to task failure in relation to the placebo (368.1 ± 49.6 s vs. 328.5 ± 56.6 s, p = 0.005). Caffeine also increased tidal volume and inspiratory time throughout the exercise (p < 0.05). Compared to task failure with placebo, task failure with caffeine intake was marked by higher (p < 0.05) minute ventilation (134.8 ± 16.4 vs. 147.6 ± 18.2 L.min-1), the ventilatory equivalent of oxygen consumption (37.8 ± 4.2 vs. 41.7 ± 5.5 units), and respiratory exchange ratio (1.12 ± 0.10 vs. 1.19 ± 0.11 units). CONCLUSION: In conclusion, ingestion of caffeine alters the breathing pattern by increasing tidal volume and lengthening the inspiratory phase of the respiratory cycle. These findings suggest that caffeine affects the ventilatory system, which may account, in part, for its ergogenic effects during high-intensity whole-body exercises.

Airflow restriction mask induces greater central fatigue after a non-exhaustive high-intensity interval exercise.

The airflow restriction mask (ARM) is a practical and inexpensive device for respiratory muscle training. Wearing an ARM has recently been combined with high-intensity interval exercise (HIIE), but its effect on neuromuscular fatigue is unknown. The present study investigated the effects of ARM wearing on neuromuscular fatigue after an HIIE session. Fourteen healthy men performed two HIIE sessions (4 × 4 min at 90% HRmax , 3 min recovery at 70% HRmax ) with or without an ARM. Neuromuscular fatigue was quantified via pre- to post-HIIE changes in maximal voluntary contraction (MVC), voluntary activation (VA, central fatigue), and potentialized evoked twitch force at 100, 10, and 1 Hz (peripheral fatigue). Blood pH and lactate were measured before and after the HIIE session, while HR, SpO2 , dyspnea, physical sensation of effort (P-RPE), and Task Effort and Awareness (TEA) were recorded every bout. The exercise-induced decrease in MVC was higher (p < 0.05) in the ARM (-28 ± 12%) than in the Control condition (-20 ± 11%). The VA decreased (p < 0.05) in the ARM (-11 ± 11%) but not in the control condition (-4 ± 5%, p > 0.05). Pre- to post-HIIE declines in evoked twitch at 100, 10, and 1 Hz were similar (p > 0.05) between ARM and control conditions (ARM: -18 ± 10, -43 ± 11 and -38 ± 12%; Control: -18 ± 14, -43 ± 12 and -37 ± 17%). When compared with the control, the HIIE bout wearing ARM was marked by higher heart rate, plasma lactate concentration, dyspnea, P-RPE and TEA, as well as lower SpO2 and blood pH. In conclusion, ARM increases perceptual and physiological stress during a HIIE, which may lead to a greater post-exercise central fatigue.

Sprint Interval Exercise Performance in Vegans.

OBJECTIVE: The impact of a vegan diet on sprint interval exercise performance is unknown. Thus, the purpose of the present study was to compare performance during a sprint interval exercise between omnivores and vegans. METHODS: Nine healthy omnivores (4 men and 5 women) and nine healthy vegans (4 men and 5 women), with similar levels of daily physical activity, performed four bouts (5-min rest between bouts) of a 30-s all-out sprint exercise on a cycle ergometer. Peak power, mean power, fatigue index, and time to reach maximal power output in each bout were recorded. RESULTS: There was a higher peak power in bouts 1 and 2 compared with bouts 3 and 4 (p < 0.02), and a higher mean power in bout 1 compared with bouts 2, 3 and 4 (p < 0.02). However, for all bouts, there were no significant difference between omnivores and vegans in peak power (7.60 ± 1.55 vs. 8.16 ± 1.27, 7.52 ± 1.6 vs 7.61 ± 0.73, 7.00 ± 1.44 vs. 7.00 ± 1.05 and 6.95 ± 1.42 vs. 6.49 ± 0.90 W.kg-1, all p > 0.05) and in mean power (5.35 ± 0.93 vs. 5.69 ± 0.84, 5.10 ± 0.88 vs. 5.21 ± 0.49, 4.79 ± 0.81 vs. 4.79 ± 0.45 and 4.81 ± 0.81 vs. 4.69 ± 0.47 W.kg-1, all p > 0.05). Fatigue index and time to reach maximal power output were not affected by diet or bouts (all p > 0.05). CONCLUSIONS: These findings indicate that a vegan diet does not compromise sprint interval exercise performance.

Distinct pacing profiles result in similar perceptual responses and neuromuscular fatigue development: Why different "roads" finish at the same line?

The current study analysed the effect of distinct pacing profiles (i.e. U, J, and inverted J) in the perceptual responses and neuromuscular fatigue (NMF) development following a 4-km cycling time trial (TT). Twenty-one cyclists with similar training status were allocated into three different groups based on their pacing profile spontaneously adopted during TT. Rating of perceived exertion (RPE), oxygen uptake (⩒O2) and heart rate (HR) were continuously recorded. NMF was assessed by using isometric maximal voluntary contractions (IMVC), while the central [i.e. voluntary activation (VA)] and peripheral fatigue of knee extensors [i.e. peak torque of potentiated twitches (TwPt)] were evaluated using electrically evoked contractions performed pre and 2 min after the TT. TT performance was not different amongst pacing profiles (U = 377 ± 20 s; J = 392 ± 23 s; J-i = 381 ± 20 s) (all P > 0.05). RPE, ⩒O2 and HR increased similarly throughout the TT regardless the pacing strategy (all P > 0.05). Similarly, IMVC (U = -9.9 ± 8.8; J = -9.6 ± 4.5%; J-i = -13.8 ± 11.3%), VA (U = -2.3 ± 1.7%; J = -5.4 ± 2.2%; J-i = -6.4 ± 4.5%) and TwPt (U = -32.5 ± 12.0%; J = -29.5 ± 8.0%; J-i = -33.6 ± 13.6%) were similar amongst pacing profiles (all P > 0.05). Therefore, endurance athletes with similar training status showed the same perceived responses and NMF development regardless the pacing profile spontaneously adopted. It was suggested that these responses occurred in order to preserve a similar rate of change in systemic responses (i.e. RPE, ⩒O2 and HR) and NMF development, ultimately resulting in same TT performance. HighlightsDifferent pacing profiles resulted in the same performance in a 4-km cycling time trial.The similar performance might be due to achievement of the same sensory tolerance limit.There was no difference for perceptual, metabolic and neuromuscular fatigue responses.

Acute Caffeine Intake Reduces Perceived Exertion But Not Muscle Pain during Moderate Intensity Cycling Exercise in Women with Fibromyalgia.

OBJECTIVE: Exacerbated perceived exertion and muscle pain responses during exercise might limit physical activity practice in fibromyalgia patients. Thus, nutritional strategies that can reduce perceived exertion and muscle pain during exercise in fibromyalgia patients would be useful. The purpose of this study was to investigate the effects of acute caffeine intake on the perceptions of exertion and muscle pain during a moderate intensity exercise in women with fibromyalgia. METHOD: Using a randomized, double-blinded, placebo-controlled and crossover experimental design, eleven sedentary women diagnosed with fibromyalgia (age: 44.6 ± 10.5 years; body mass index: 28.5 ± 4.5 kg.m-2) ingested a capsule containing either caffeine (5 mg per kg of body mass) or cellulose (placebo), 60 minutes before performing a 30-minute constant-load cycling exercise, with work rate fixed at 50% of their individual peak workload attained in an incremental exercise test. Ratings of perceived leg muscle pain and perceived exertion were assessed every 5 minutes of exercise. RESULTS: The perceived leg muscle pain was similar (F(1,10) = 1.18, p = 0.30, ŋ2 = 0.11) between caffeine (2.1 ± 1.2 arbitrary units) and placebo conditions (2.2 ± 0.9 arbitrary units). The perceived exertion, however, was on average 8 ± 6% lower (F(1,10) = 12.13; p = 0.006; ŋ2 = 0.55) during exercise in the caffeine condition (12.4 ± 1.3 arbitrary units) than in the placebo condition (13.1 ± 1.1 arbitrary units). CONCLUSIONS: These findings indicate that acute caffeine intake could be an attractive strategy to attenuate the exacerbated perceived exertion of fibromyalgia patients during moderate intensity exercise.

Air pollution and high-intensity interval exercise: Implications to anti-inflammatory balance, metabolome and cardiovascular responses.

High-intensity interval exercise (HIIE) is an effective non-pharmacological tool for improving physiological responses related to health. When HIIE is performed in urban centers, however, the exerciser is exposed to traffic-related air pollution (TRAP), which is associated with metabolic, anti-inflammatory imbalance and cardiovascular diseases. This paradoxical combination has the potential for conflicting health effects. Thus, the aim of this study was to determine the effects of HIIE performed in TRAP exposure on serum cytokines, non-target metabolomics and cardiovascular parameters. Fifteen participants performed HIIE in a chamber capable to deliver filtered air (FA condition) or non-filtered air (TRAP condition) from a polluted site adjacent to the exposure chamber. Non-target blood serum metabolomics, blood serum cytokines and blood pressure analyses were collected in both FA and TRAP conditions at baseline, 10 min after exercise, and 1 h after exercise. The TRAP increased IL-6 concentration by 1.7 times 1 h after exercise (p < 0.01) and did not change the anti-inflammatory balance (IL-10/TNF-α ratio). In contrast, FA led to an increase in IL-10 and IL-10/TNF-α ratio (p < 0.01), by 2.1 and 2.3 times, respectively. The enrichment analysis showed incomplete fatty acid metabolism under the TRAP condition (p < 0.05) 10 min after exercise. There was also an overactivity of ketone body metabolism (p < 0.05) at 10 min and at 1 h after exercise with TRAP. Exercise-induced acute decrease in systolic blood pressure (SBP) was not observed at 10 min and impaired at 1 h after exercise (p < 0.05). These findings reveal that TRAP potentially attenuates health benefits often related to HIIE. For instance, the anti-inflammatory balance was impaired, accompanied by accumulation of metabolites related to energy supply and reduction to exercise-induced decrease in SBP.

Traffic-related air pollution and endurance exercise: Characterizing non-targeted serum metabolomics profiling.

Although the exposure to traffic-related air pollution (TRAP) has emerged as one of main problem worldwide to inhabitants' health in urban centers, its impact on metabolic responses during exercise is poorly understood. The aim of study was to characterize the profile of non-target serum metabolomics during prolonged exercise performed under TRAP conditions. Ten healthy men completed two 90 min constant-load cycling trials under conditions of either TRAP or filtered air. Experimental trials were performed in a chamber located on an avenue with a high volume of vehicle traffic. Blood samples were taken at 30 min, 60 min, and 90 min of exercise. Based on Nuclear Magnetic Resonance metabolomics, the non-target analysis was used to assess the metabolic profile. Twelve, 16 and 18 metabolites were identified as discriminants. These were: at 30 min of exercise, the coefficient of determination (R2) 0.98, the predictive relevance, (Q2) 0.12, and the area under the curve (AUC) 0.91. After 60 min of exercise: (R2: 0.99, Q2: 0.09, AUC: 0.94); and at 90 min of exercise (R2: 0.91, Q2: <0.01, AUC: 0.89), respectively. The discriminant metabolites were then considered for the target analysis, which demonstrated that the metabolic pathways of glycine and serine metabolism (p = 0.03) had been altered under TRAP conditions at 30 min of exercise; arginine and proline metabolism (p = 0.04) at 60 min of exercise; and glycolysis (p = 0.05) at 90 min of exercise. The present results suggest that exposure to TRAP during prolonged exercise leads to a significant change in metabolomics, characterized by a transitional pattern and lastly, impairs the glucose metabolism.

MBboard: Validity and Reliability of a New Tool Developed to Evaluate Specific Strength in Rock Climbers.

In the present study, we analysed the validity and reliability of a new tool designed to assist the measurement of maximal upper-limb strength in rock climbers in a specific way, named MBboard. The MBboard consists of an artificial small climbing hold affixed to a wooden board, which is connected to any cable-motion strength equipment to determine the maximum dynamic strength (MBboard-1RM). Ten male rock climbers (Rock Climbing Group, RCG = 10) and ten physically active men (Control Group, CG = 10) performed, on three separate occasions, a familiarization session with procedures adopted during MBboard-1RM testing and two experimental trials (i.e., test and retest) to determine the construct validity and reliability of the MBboard during unilateral seated cable row exercise. In the first trial, the electromyographic activity (EMG) was recorded from the flexor digitorum superficialis. The self-reported climbing ability was also recorded. The RCG had superior performance (i.e. 37.5%) and EMG activity (i.e. 51%) in MBboard-1RM testing when compared with the CG (p < 0.05). There was a significant correlation between the MBboard-1RM results and climbing ability (r > 0.72, p < 0.05). Intraclass correlation coefficient analysis revealed good reliability within trials (ICC > 0.79, p < 0.05). These findings suggest that the MBboard is a valid and reliable tool to assess rock climbing-specific maximal strength. The validity of MBboard-1RM appears to be related to the finger flexor muscles activation, probably reflecting the specific adaptations resulting from long-term practice of this sport discipline.

Caffeine during High-Intensity Whole-Body Exercise: An Integrative Approach beyond the Central Nervous System.

Caffeine is one of the most consumed ergogenic aids around the world. Many studies support the ergogenic effect of caffeine over a large spectrum of exercise types. While the stimulatory effect of caffeine on the central nervous system is the well-accepted mechanism explaining improvements in exercise performance during high-intensity whole-body exercise, in which other physiological systems such as pulmonary, cardiovascular, and muscular systems are maximally activated, a direct effect of caffeine on such systems cannot be ignored. A better understanding of the effects of caffeine on multiple physiological systems during high-intensity whole-body exercise might help to expand its use in different sporting contexts (e.g., competitions in different environments, such as altitude) or even assist the treatment of some diseases (e.g., chronic obstructive pulmonary disease). In the present narrative review, we explore the potential effects of caffeine on the pulmonary, cardiovascular, and muscular systems, and describe how such alterations may interact and thus contribute to the ergogenic effects of caffeine during high-intensity whole-body exercise. This integrative approach provides insights regarding how caffeine influences endurance performance and may drive further studies exploring its mechanisms of action in a broader perspective.