ABSTRACT
In article described research the results of the prevalence of the genetic polymorphism of the gene Methylentetrahydrofolatereductase C677T (MTHFR) in 130 patients with pseudarthrosis of long bones and in those with consolidated fractures. The incidence of allele-T among patients with pseudarthrosis was 1.4 times higher than among those with consolidated fractures. Pathological genotype MTHFR 677-TT was associated with the development avital types of pseudarthrosis and increase the proportion of people with hyperhomocysteinemia, high content of inflammatory mediators and development refracture.
Subject(s)
Hyperhomocysteinemia/enzymology , Inflammation Mediators/blood , Methylenetetrahydrofolate Reductase (NADPH2)/genetics , Polymorphism, Genetic , Pseudarthrosis/enzymology , Tibial Fractures/enzymology , Adult , C-Reactive Protein/immunology , Female , Fracture Healing/genetics , Fracture Healing/physiology , Gene Frequency , Heterozygote , Hip Fractures/enzymology , Hip Fractures/epidemiology , Homocysteine/blood , Homozygote , Humans , Hyperhomocysteinemia/complications , Hyperhomocysteinemia/epidemiology , Hyperhomocysteinemia/immunology , Inflammation Mediators/immunology , Interleukin-6/blood , Interleukin-6/immunology , Male , Pseudarthrosis/complications , Pseudarthrosis/epidemiology , Pseudarthrosis/immunology , Tibial Fractures/complications , Tibial Fractures/epidemiology , Tibial Fractures/immunologyABSTRACT
In article described research of frequency of endothelial dysfunction in 153 patients with pseudarthrosis of long bones and in individuals with consolidated fractures. The reparative regeneration are associated by structural and functional disorders of the central and peripheral vessels as endothelial dysfunction, thickening of the intima-media, prevails at hypoplastic and atrophic types bone nonunion, neurotrofic syndrome and refractures. Endothelial function was significantly dependent on the levels of homocysteine, total cholesterol and interleukin-6 in serum.
Subject(s)
Endothelium, Vascular/physiopathology , Hyperhomocysteinemia/metabolism , Hyperhomocysteinemia/physiopathology , Pseudarthrosis/metabolism , Pseudarthrosis/physiopathology , Adult , Cholesterol/blood , Endothelium, Vascular/pathology , Female , Homocysteine/blood , Humans , Hyperhomocysteinemia/complications , Hyperhomocysteinemia/pathology , Interleukin-6/blood , Male , Osteogenesis/physiology , Pseudarthrosis/complications , Pseudarthrosis/pathology , Tunica Media/pathology , Tunica Media/physiopathologyABSTRACT
In article described research of the metabolic status and bone mineral density in 153 patients with with pseudarthrosis of long bones, in individuals with consolidated fractures and healthy people. The violations of reparative osteogenesis at hyperhomocysteinemia are accompanied by disturbances of the functional state of bone tissue, inhibition of biosynthetic and increased destruction processes, reduced bone mineral density in the formation of osteopenia and osteoporosis. The degree and direction of change of bone depends on the type of violation of reparative osteogenesis.
Subject(s)
Bone Diseases, Metabolic/blood , Bone and Bones/metabolism , Fractures, Bone/blood , Hyperhomocysteinemia/blood , Osteoporosis/blood , Pseudarthrosis/blood , Adult , Bone Diseases, Metabolic/diagnostic imaging , Bone Diseases, Metabolic/pathology , Bone and Bones/diagnostic imaging , Bone and Bones/pathology , Cartilage Oligomeric Matrix Protein/blood , Case-Control Studies , Collagen/blood , Female , Fractures, Bone/diagnostic imaging , Fractures, Bone/pathology , Glycosaminoglycans/blood , Humans , Hydroxyproline/blood , Hyperhomocysteinemia/complications , Hyperhomocysteinemia/diagnostic imaging , Hyperhomocysteinemia/pathology , Male , Osteocalcin/blood , Osteoporosis/diagnostic imaging , Osteoporosis/pathology , Peptide Fragments/blood , Pseudarthrosis/complications , Pseudarthrosis/diagnostic imaging , Pseudarthrosis/pathology , Pyrimidine Dimers/blood , UltrasonographyABSTRACT
The author presents in the article the results of treatment patients with fibula stump syndrome. Some aspects of pathogenesis of development of this form of amputation pain after amputation were clarified by the author in the article as well as clinical and morphological disease criteria. Differential assessment of efficiency of conservative treatment and surgery depending on the severity of pain syndrome has been carried out.