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1.
Environ Monit Assess ; 195(4): 515, 2023 Mar 28.
Article in English | MEDLINE | ID: mdl-36976412

ABSTRACT

A dense network of rain gauges and considerably large variability of the southwest monsoon precipitation across the country make India a suitable test-bed to evaluate any satellite-based precipitation product. In this paper, three real-time infrared-only precipitation products derived from the INSAT-3D satellite namely, INSAT Multispectral Rainfall (IMR), Corrected IMR (IMC) and Hydro-Estimator (HEM) and three rain gauge-adjusted Global Precipitation Measurement (GPM)-based multi-satellite precipitation products namely, Integrated Multi-satellitE Retrievals for GPM (IMERG), Global Satellite Mapping of Precipitation (GSMaP) and an Indian merged satellite-gauge product (INMSG) have been evaluated over India at a daily timescale for the southwest monsoon seasons of 2020 and 2021. An evaluation against rain gauge-based gridded reference dataset shows noticeable reduction of bias in IMC product over IMR, primarily over the orographic regions. However, INSAT-3D infrared-only precipitation retrieval algorithms have limitations in shallow and convective precipitation estimation. Among rain gauge-adjusted multi-satellite products, INMSG is shown to be the best product in the monsoon precipitation estimation over India due to use of rather larger number of rain gauges than IMERG and GSMaP products. All satellite-derived precipitation products, i.e. infrared-only and gauge-adjusted multi-satellite products underestimate heavy monsoon precipitation by 50-70%. The bias decomposition analysis indicates that a simple statistical bias correction would considerably improve the performance of the INSAT-3D precipitation products over the central India, but the same might not work over the west coast due to rather larger contributions of both positive and negative hit bias components. Although rain gauge-adjusted multi-satellite precipitation products show very small or negligible total biases in the monsoon precipitation estimation, positive and negative hit bias components are considerable over the west coast and central India. Furthermore, rain gauge-adjusted multi-satellite precipitation products underestimate very heavy to extremely heavy precipitation with larger magnitudes than the INSAT-3D derived precipitation products over the central India. Among the rain gauge-adjusted multi-satellite precipitation products, INMSG has smaller bias and error than IMERG and GSMaP products for very heavy to extremely heavy monsoon precipitation over the west coast and central India. Preliminary results of this study would be useful for end users in choosing a better precipitation product for real-time and research applications as well as for algorithm developers in further improving these products.


Subject(s)
Cyclonic Storms , Environmental Monitoring , Environmental Monitoring/methods , Rain , Seasons , India
2.
J Environ Public Health ; 2018: 7973519, 2018.
Article in English | MEDLINE | ID: mdl-30515228

ABSTRACT

Background: Ahmedabad implemented South Asia's first heat action plan (HAP) after a 2010 heatwave. This study evaluates the HAP's impact on all-cause mortality in 2014-2015 relative to a 2007-2010 baseline. Methods: We analyzed daily maximum temperature (T max)-mortality relationships before and after HAP. We estimated rate ratios (RRs) for daily mortality using distributed lag nonlinear models and mortality incidence rates (IRs) for HAP warning days, comparing pre- and post-HAP periods, and calculated incidence rate ratios (IRRs). We estimated the number of deaths avoided after HAP implementation using pre- and post-HAP IRs. Results: The maximum pre-HAP RR was 2.34 (95%CI 1.98-2.76) at 47°C (lag 0), and the maximum post-HAP RR was 1.25 (1.02-1.53) estimated at 47°C (lag 0). Post-to-pre-HAP nonlagged mortality IRR for T max over 40°C was 0.95 (0.73-1.22) and 0.73 (0.29-1.81) for T max over 45°C. An estimated 1,190 (95%CI 162-2,218) average annualized deaths were avoided in the post-HAP period. Conclusion: Extreme heat and HAP warnings after implementation were associated with decreased summertime all-cause mortality rates, with largest declines at highest temperatures. Ahmedabad's plan can serve as a guide for other cities attempting to increase resilience to extreme heat.


Subject(s)
Climate Change , Extreme Heat/adverse effects , Mortality , Cities , Humans , India , Pilot Projects , Seasons
3.
Arch Orthop Trauma Surg ; 132(6): 875-81, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22526193

ABSTRACT

BACKGROUND: Since the introduction of mobile bearing total knee designs nearly 30 years back, many studies have been done to evaluate its long-term result. Comparison with fixed bearing designs has been done in the past, but the studies were confounded by variables such as disease, surgeon, bone quality, pain tolerance, etc. We attempt to eliminate these variables in this study. METHODS: A total of 50 patients who had bilateral arthritis of the knee with similar deformity and pre-operative range of motion on both sides agreed to have one knee replaced with mobile bearing total knee design (PFC-RP) and the other with a fixed bearing design (PFC Sigma) were prospectively evaluated. Comparative analysis of both the designs was done at a mean follow-up of 40 months, minimizing patient, surgeon and observer related bias. Clinical and radiographic outcome, survival and complication rates were compared. RESULTS: At a mean follow-up of 40 months (range 36-47 months), no benefit of mobile bearing (PFC-RP) over fixed bearing design (PFC Sigma) could be demonstrated with respect to Knee Society scores, pain scores, range of flexion, subject preference or patello-femoral complication rates. Radiographs showed no difference in prosthetic alignment. No patient required a revision surgery till last follow-up. CONCLUSIONS: Our study demonstrated no advantage of the mobile-bearing arthroplasty over fixed bearing arthroplasty with regard to clinical results at short-term follow-up. However, longer follow-up is necessary to confirm whether these results are sustained.


Subject(s)
Arthroplasty, Replacement, Knee/methods , Osteoarthritis, Knee/surgery , Aged , Chi-Square Distribution , Female , Follow-Up Studies , Humans , Male , Middle Aged , Osteoarthritis, Knee/diagnostic imaging , Pain Measurement , Postoperative Complications , Prospective Studies , Radiography , Range of Motion, Articular , Survival Rate , Treatment Outcome , Weight-Bearing
4.
Arch Orthop Trauma Surg ; 128(4): 355-62, 2008 Apr.
Article in English | MEDLINE | ID: mdl-17457595

ABSTRACT

INTRODUCTION: Cementless femoral revision has become increasingly popular because the cementless implants provide the potential for long-term biologic implant fixation. The IOTA interlocking femoral stem is a hydroxyapatite-coated stem with the option of interlocking the stem distally. The aim of the current study was to evaluate the short-term results of IOTA interlocking stem. MATERIALS AND METHODS: We retrospectively reviewed the results of 18 total hip arthroplasties in 17 patients performed between July 2002 and 2004 using the IOTA interlocking stem. In-patient records were retrieved and in addition to demographic data the indication for revision, the preoperative and postoperative Harris Hip scores, need for allografts were noted. The bone deficiency was classified based on the AAOS classification. Intraoperative complications and problems if any were retrieved from the authors' operative notes. Radiographs at the final follow up were evaluated by the criteria described by Engh et al. (Clin Orthop 257:107-128, 1990) RESULTS: Average age at the time of revision was 57 years. Preoperatively five femora showed type I deficiency, type II deficiency was seen in three, type III in nine and type IV deficiency in one femur. In five hips the calcar replacing prosthesis was implanted to manage the proximal calcar defect, in one hip allograft was used to reconstruct the calcar. One patient sustained intraoperative fracture of the shaft of the femur while implanting the trial prosthesis and one patient had a perforation of the posterior cortex of femur while trying to remove the cement. The mean follow up period was 33.5 months (range 27-45 months). The mean preoperative Harris Hip score was 36 (range 23-50), which improved to 77 (range 68-92) at the time of final follow up. None of the stems required revision and at minimum 27 months follow up, bony ingrowth was noted in 83.33% of the stems. CONCLUSION: IOTA interlocking stem has shown promising short-term results for femoral revisions. The advantages are initial axial and rotational stability and consistent bony in growth owing to hydroxyapatite coating. Intraoperative fracture is a potential drawback because of the straight nature of the stem. The calcar replacing option of the stem is especially useful in patients with deficient calcar as a substitute for the allograft.


Subject(s)
Hip Prosthesis , Adult , Aged , Arthroplasty, Replacement, Hip , Biocompatible Materials/therapeutic use , Durapatite/therapeutic use , Female , Humans , Male , Middle Aged , Prosthesis Design , Reoperation , Retrospective Studies , Treatment Outcome
5.
J Orthop Surg (Hong Kong) ; 15(2): 174-6, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17709856

ABSTRACT

PURPOSE: To assess the results of treatment for flexion-type supracondylar humeral fracture in children. METHODS: The treatment of 14 children with flexion-type supracondylar humeral fracture was reviewed. Severity was classified according to the Gartland system for extension-type fractures. Type-I fractures were treated with immobilisation in an extension cast. For type-II and -III fractures, closed reduction was first attempted followed by percutaneous pinning. If closed reduction failed, open reduction and internal fixation was performed. RESULTS: Patients were followed up for at least one year (range, 14-36 months). Treatment results were excellent in 7 patients, good in 4, fair in 3, and poor in none. Patients were pain-free and satisfied and none suffered any activity restriction. CONCLUSION: Closed reduction and percutaneous pinning is a good treatment option for type-II and -III flexion-type supracondylar humeral fractures.


Subject(s)
Bone Nails , Casts, Surgical , Fracture Fixation/instrumentation , Humeral Fractures/therapy , Child , Child, Preschool , Elbow Joint/diagnostic imaging , Elbow Joint/physiopathology , Female , Follow-Up Studies , Humans , Humeral Fractures/diagnostic imaging , Humeral Fractures/physiopathology , Male , Patient Satisfaction , Radiography , Range of Motion, Articular , Treatment Outcome
6.
Indian J Orthop ; 41(1): 57-61, 2007 Jan.
Article in English | MEDLINE | ID: mdl-21124684

ABSTRACT

OBJECTIVE: To compare the results of endoscopic carpal tunnel release (CTR) with open CTR in patients with idiopathic Carpal tunnel syndrome (CTS). MATERIALS AND METHODS: Seventy-one patients with CTS were enrolled in a prospective randomized study from May 2003 to December 2005. All patients had clinical signs or symptoms and electro-diagnostic findings consistent with carpal tunnel syndrome and had not responded to nonoperative management. Sixty-one cases were available for follow-up. Endoscopic CTR was performed in 30 CTS patients and open CTR was performed in 31 wrists (30 patients). Various parameters were evaluated, including each patient's symptom amelioration, complications, operation time, time needed to resume normal lifestyle and the frequency of revision surgery. All the patients were followed up for six months. RESULTS: During the initial months after surgery, the patients treated with the endoscopic method were better symptomatically and functionally. Local wound problems in terms of scarring or scar tenderness were significantly more pronounced in patients undergoing open CTR compared to patients undergoing endoscopic CTR. Average delay to return to normal activity was appreciably less in group undergoing endoscopic CTR. No significant difference was observed between the endoscopic CTR group and open CTR group in regard to symptom amelioration, electromyographic testing and complications at the end of six months. CONCLUSION: Short-term results were better with the endoscopic method as there was no scar tenderness. Results at six months were comparable in both groups.

7.
Clin Orthop Relat Res ; 451: 87-95, 2006 Oct.
Article in English | MEDLINE | ID: mdl-16906096

ABSTRACT

We compared the results of total knee arthroplasties in patients with stiff or ankylosed knees. We retrospectively reviewed 90 total knee arthroplasties in 52 patients with minimum 2 years followup who had less than a 50 degrees arc of flexion preoperatively. Preoperative and intraoperative data were retrieved from a computerized database. Patients were followed for an average of 6.5 years at an outpatient department. Knee Society knee scores improved from 34.6 points preoperatively to 89.5 points postoperatively in the stiff knees and from 47 points preoperatively to 75 points postoperatively in the ankylosed knees. The arc of flexion improved from 35 degrees -69 degrees preoperatively to 1 degrees -94 degrees postoperatively in the stiff knees and from 0 degrees to 3 degrees -77 degrees in the ankylosed knees. There were major complications in four of the 26 ankylosed knees and in two of the 64 stiff knees. The data suggest results of total knee arthroplasty are better in patients with stiff knees than in patients with ankylosed knees.


Subject(s)
Ankylosis/physiopathology , Ankylosis/surgery , Arthritis/physiopathology , Arthritis/surgery , Arthroplasty, Replacement, Knee , Range of Motion, Articular/physiology , Adult , Aged , Female , Follow-Up Studies , Humans , Male , Middle Aged , Recovery of Function/physiology , Retrospective Studies , Treatment Outcome
9.
J Orthop Surg (Hong Kong) ; 14(1): 81-3, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16598094

ABSTRACT

Eosinophilic granuloma is the most common and benign form of a rare proliferative disorder: Langerhans' cell histiocytosis. Spinal involvement is rare and only 15 adult cases have been reported. We present an unusual variant of eosinophilic granuloma in a 25-year-old woman with radiological evidence of vertebra plana. Plain radiography, magnetic resonance imaging, bone scan, and blood tests were carried out, and a specimen was taken from L4 using computed tomography-guided biopsy. Gram staining, acid fast bacillus smear, bacterial and fungal cultures were negative. Histological examination of the biopsy showed features of eosinophilic granuloma with aggregates of Langerhans histiocytes. The patient was treated with low-grade radiotherapy at 150 cGy per day for 7 days. She was asymptomatic at one-year follow-up although the radiological picture was unchanged.


Subject(s)
Eosinophilic Granuloma/diagnosis , Spinal Diseases/diagnosis , Adult , Eosinophilic Granuloma/pathology , Female , Humans , Lumbar Vertebrae/diagnostic imaging , Lumbar Vertebrae/pathology , Magnetic Resonance Imaging , Radiography , Spinal Diseases/pathology
10.
J Bone Joint Surg Br ; 88(3): 298-303, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16498000

ABSTRACT

We compared the safety and outcome of one-stage bilateral total hip arthroplasty with those of a two-stage procedure during different admissions in a prospective, randomised controlled trial in an Asian population. Of 168 patients included in the study, 83 had a single- and 85 a two-stage procedure. Most of the patients (59.9%) suffered from inflammatory arthritis. The intra-operative complications, early systemic complications, the operating time, positioning of the components, the functional score, restoration of limb length and survival rates at 96 months were similar in the two groups. The total estimated blood loss was significantly lower in patients undergoing a one-stage procedure than in patients who had a two-stage procedure, but the transfusion requirements were significantly higher in the former group (p=0.001). The hospital stay was significantly shorter in the one-stage group, 7.25 days (sd 1.30; 5 to 20) compared with 10 days (sd 1.65; 8 to 24) in the two-stage group (p=0.023). We believe that a one-stage procedure is safe and appropriate in our population.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Hip Joint/surgery , Adult , Blood Loss, Surgical , Blood Transfusion , Female , Hip Dislocation/etiology , Hip Dislocation/surgery , Hip Joint/diagnostic imaging , Hip Prosthesis , Humans , Intraoperative Complications/surgery , Length of Stay , Male , Middle Aged , Postoperative Complications/etiology , Prospective Studies , Radiography , Treatment Outcome , Walking
11.
J Orthop Surg (Hong Kong) ; 13(3): 303-6, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16365497

ABSTRACT

Bilateral simultaneous anterior dislocation of the shoulders with bilateral 3-part fracture of the proximal humeri is unusual. A 42-year-old man presented with pain and restriction of movement on both shoulders. He was injured by a heavy object falling over his back while he was leaning forward holding an overhead bar. His arms were abducted and externally rotated. The injury was not correctly diagnosed, and the patient was treated with repeated manipulations and splintage for 2 weeks. Radiological examination revealed bilateral anterior dislocation of the shoulders with displaced 3-part fractures of the proximal humeri involving the shaft, greater tuberosity, and head. The patient was treated with open reduction and internal fixation through a deltopectoral approach using multiple Kirschner wires. The shoulders were kept immobilised for 3 weeks until the removal of the wires. The patient was able to resume work 3 months after surgery. He had an excellent and comfortable range of motion in both shoulders at one-year follow-up.


Subject(s)
Shoulder Dislocation/surgery , Shoulder Fractures/surgery , Adult , Bone Wires , Diagnostic Errors , Humans , Male , Physical Therapy Modalities , Range of Motion, Articular , Shoulder Dislocation/diagnosis , Shoulder Fractures/diagnosis
12.
J Bone Joint Surg Br ; 87(11): 1549-52, 2005 Nov.
Article in English | MEDLINE | ID: mdl-16260678

ABSTRACT

We present seven patients with recurrent haemarthroses after total knee arthroplasty, caused by an inherent platelet function defect. These patients developed painful knee swelling, persistent bleeding and/or wound breakdown, a platelet factor 3 availability defect being identified in all cases. Surgical exploration, with joint debridement, lavage and synovectomy, was performed in four patients who did not improve with conservative therapy. Histopathological examination of synovium revealed a focal synovial reaction with histiocytic infiltration, and occasional foreign-body giant cells. One patient required an early revision because of aseptic loosening of their tibial component. The condition was treated by single-donor platelet transfusions with good results. The diagnosis, management, and relevance of this disorder are discussed.


Subject(s)
Arthroplasty, Replacement, Knee/adverse effects , Hemarthrosis/etiology , Platelet Factor 3/physiology , Aged , Blood Platelets/physiology , Female , Hemarthrosis/blood , Humans , Male , Middle Aged , Prosthesis Failure , Recurrence , Reoperation
13.
J Bone Joint Surg Am ; 87(10): 2290-6, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16203896

ABSTRACT

BACKGROUND: Durable long-term independent results with the Low Contact Stress rotating-platform (mobile-bearing) and the Insall Burstein-II (fixed-bearing) total knee prostheses have been reported, but no studies describing either the mid-term or long-term results and comparing the two prostheses are available, to our knowledge. METHODS: Thirty-two patients who had bilateral arthritis of the knee with similar deformity and preoperative range of motion on both sides and who agreed to have one knee replaced with a mobile-bearing total knee design and the other with a fixed-bearing design were prospectively evaluated. Comparative analysis of both designs was done at a mean follow-up period of six years, minimizing patient, surgeon, and observer-related bias. Clinical and radiographic outcome, survival, and complication rates were compared. RESULTS: Patients with osteoarthritis had better function scores and range of motion compared with patients with rheumatoid arthritis. However, with the numbers available, no benefit of mobile-bearing over fixed-bearing designs could be demonstrated with respect to Knee Society scores, range of flexion, subject preference, or patellofemoral complication rates. Radiographs showed no difference in prosthetic alignment. Two knees with a mobile-bearing prosthesis required a reoperation: one had an early revision because of bearing dislocation and another required conversion to an arthrodesis to treat a deep infection. CONCLUSIONS: We found no advantage of the mobile-bearing arthroplasty over the fixed-bearing arthroplasty with regard to the clinical results at mid-term follow-up. The risk of bearing subluxation and dislocation in knees with the mobile-bearing prosthesis is a cause for concern and may necessitate early revision. LEVEL OF EVIDENCE: Therapeutic Level II.


Subject(s)
Arthritis, Rheumatoid/surgery , Arthroplasty, Replacement, Knee/instrumentation , Knee Prosthesis , Osteoarthritis, Knee/surgery , Postoperative Complications , Adult , Aged , Arthroplasty, Replacement, Knee/adverse effects , Female , Follow-Up Studies , Humans , Joint Instability/etiology , Male , Middle Aged , Treatment Outcome , Weight-Bearing
16.
Knee ; 11(1): 7-8, 2004 Feb.
Article in English | MEDLINE | ID: mdl-14967320

ABSTRACT

All the described tests for the detection of anterior cruciate ligament (ACL) tear are passive tests. For obese or muscular built patients these tests are cumbersome and often unsuitable. We describe for the first time a new method, the 'Delhi active test', by which a torn ACL can be detected irrespective of the size or build of the patient. The results of this test are reproducible and the diagnostic accuracy is comparable with other tests. We suggest that the 'Delhi active test' be used as one of the routine clinical methods to detect the torn ACL.


Subject(s)
Anterior Cruciate Ligament Injuries , Joint Instability/diagnosis , Knee Injuries/diagnosis , Knee Joint/pathology , Range of Motion, Articular , Anterior Cruciate Ligament/pathology , Anterior Cruciate Ligament/physiopathology , Humans , Joint Instability/physiopathology , Knee Injuries/physiopathology , Knee Joint/physiopathology , Range of Motion, Articular/physiology , Reproducibility of Results
17.
J Arthroplasty ; 18(8): 1016-22, 2003 Dec.
Article in English | MEDLINE | ID: mdl-14658106

ABSTRACT

Low-contact-stress (LCS) rotating-platform knee arthroplasties in 31 consecutive patients with 50 deformed knees were evaluated at a mean follow-up of 4.5 years (range, 4-6 years). Overall results were good in 72% of 22 osteoarthritic knees and 71.4% of 28 rheumatoid knees. None of the knees showed any change in component position and alignment, osteolysis, or cement-bone radiolucency during follow-up. LCS prosthesis takes care of some rotational component mismatch. Complications included 2% dislocation, 4% anteroposterior instability, and 10% subluxation of the rotating platform. The overall reoperation rate of 10% was significantly higher than reported for the fixed bearing series, and we feel that LCS prosthesis is unsuitable for severely deformed knees.


Subject(s)
Arthritis, Rheumatoid/surgery , Arthroplasty, Replacement, Knee , Knee Prosthesis , Osteoarthritis, Knee/surgery , Arthritis, Rheumatoid/diagnostic imaging , Female , Humans , Male , Middle Aged , Prosthesis Design , Radiography , Reoperation , Rotation , Treatment Outcome
18.
J Orthop Surg (Hong Kong) ; 11(1): 90-3, 2003 Jun.
Article in English | MEDLINE | ID: mdl-12810978

ABSTRACT

Desmoplastic fibroma is a rare benign tumour of bone. Diagnosis is not easy and is often made by excluding other tumours. Histopathological diagnosis of this tumour is also sometimes not easy. The treatment modalities for this tumour are non-uniform and often controversial. In the present case surgical options were left aside because the patient did not consent to surgery, so radiotherapy was used, with success at 3-year follow-up. This case is presented here along with a review of relevant literature.


Subject(s)
Bone Neoplasms/radiotherapy , Fibroma, Desmoplastic/radiotherapy , Adult , Female , Humans
19.
Injury ; 33(6): 517-22, 2002 Jul.
Article in English | MEDLINE | ID: mdl-12098550

ABSTRACT

We reviewed 44 children with a widely displaced supracondylar fracture of the humerus (Gartland grade III) treated with primary open reduction and cross pinning. The average age was 8 years and the mean delay in presentation was 34 h. Comminution of the medial supracondylar pillar was seen in 57% of the cases. After treatment, the range of the elbow motion was restricted in eight patients. Cubitus varus was not seen. There was no deep infection or myositis ossificans. Post-operatively, five children had a temporary nerve palsy. According to Flynns' criteria, 42 patients had a satisfactory outcome.


Subject(s)
Fracture Fixation/methods , Humeral Fractures/surgery , Adolescent , Bone Nails , Bone Wires , Child , Elbow Joint/physiopathology , Female , Follow-Up Studies , Fractures, Comminuted/surgery , Humans , Humeral Fractures/diagnostic imaging , Male , Radiography , Range of Motion, Articular , Treatment Outcome
20.
Arch Orthop Trauma Surg ; 121(3): 152-7, 2001.
Article in English | MEDLINE | ID: mdl-11262781

ABSTRACT

Twenty-one affected elbows in 14 known hemophilic patients undergoing treatment at the Hemophilia Clinic of our institution between 1994 and 1997 were evaluated using the clinical evaluation score of the Orthopaedic Advisory Committee of the World Federation of Hemophilia and radiological examination using the Pettersson score. The mean age of patients was 16.2 years (range 10-25 years), and all patients except 1 had severe hemophilia with factor VIII levels less than 1% of normal. The mean duration of disease at the time of presentation was 12.8 years. The mean clinical score was 6, while the mean radiological score was 4.9. There was a positive correlation between the clinical and radiological scores (P < 0.0001). However, the clinical and radiological scores did not correlate with either duration of disease or joint bleeding score. Two new radiological signs of obliteration of the capitello-lateral epicondyle groove with rounding off of the lateral aspect of the distal humerus and lipping of the medial trochlear surface were also recognized in hemophilic arthropathy of the elbow.


Subject(s)
Elbow Joint/diagnostic imaging , Hemarthrosis/etiology , Hemophilia A/complications , Adolescent , Adult , Child , Elbow Joint/physiopathology , Female , Hemarthrosis/diagnosis , Hemophilia A/diagnosis , Hemophilia A/therapy , Humans , Male , Pain Measurement , Radiography , Range of Motion, Articular/physiology , Risk Assessment , Sensitivity and Specificity , Severity of Illness Index
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