Zinc tetrafluoroborate Catalyzed Stereo- and Regioselective O-Glycosylation for the Direct Synthesis of ß-Glycosides from Armed O­Glycosyl Trichloroacetimidates.

Efficient stereo and regio-selective O-glycosylation methods remain essential to capacitate the studies of sugars and sugar derivatives in various disciplines. In this work, we demonstrated an operationally simple and cost-effective strategy for the synthesis of 1,2-trans glycosides by the activation of armed O-glycosyl trichloroacetimidates donor using zinc tetrafluoroborate. This mild, transition metal-free, and scalable approach allowed stereo- and regioselective synthesis of ß-glycosides with a wide range of acceptors containing various protecting groups/functionalities. This method is exemplified by synthesizing a branched tri-saccharide fragment related to the cell wall O-polysaccharide of E.Coli O27.

Total Synthesis of 6-Deoxy-l-talose Containing a Pentasaccharide Repeating Unit of Acinetobacter baumannii K11 Capsular Polysaccharides.

Herein, we report a concise synthetic approach for the first total synthesis of a pentasaccharide repeating unit of Acinetobacter baumannii K11 capsular polysaccharides containing a rare sugar 6-deoxy-l-talose. The pentasaccharide was synthesized in a convergent manner using a [3 + 2] block glycosylation strategy. During this synthetic strive, we used a 2,2,2-trichloroethoxycarbonyl (Troc)-protected monosaccharide unit to achieve a high yield during the glycosylation to synthesize a trisaccharide, and chemoselective deprotection of the Troc group from the trisaccharide was carried out under a mild, pH-neutral condition, keeping the O-glycosidic bond, azido, and acid/base sensitive group intact. A thiotolylglycoside disaccharide donor containing 6-deoxy-l-talose was synthesized for the first time by the armed-disarmed glycosylation method between two thiotolylglycosides.