Postoperative Effect Observation and Clinical Study of Dahuang Zhechong Pills from Jingui Yaolue in Treating Patients with Early-to-Mid Prostate Cancer Undergoing Radical Resection.

Objective: To explore the effect of applying Dahuang Zhechong pills (DHZCP) from Jingui Yaolue to patients with early-to-mid prostate cancer undergoing radical resection and carry out a theoretical clinical study of traditional Chinese medicine (TCM) to verify the effect of DHZCP formula under the guidance of TCM theory. Methods: The clinical data of 98 patients with early-to-mid prostate cancer undergoing radical resection treated in our hospital (July 2014 to July 2016) were selected for the retrospective analysis, and the patients were divided into group A (n = 49, routine hormonal therapy) and group B (n = 49, routine hormonal therapy plus DHZCP) according to the double blind method, so as to compare the trauma symptoms, cancer recurrence rate, etc., after treatment between the two groups. Results: Compared with group A, group B obtained significantly higher total effective rate of complication treatment at different time points (P < 0.05), significantly lower mean HAMA score after treatment (P < 0.05), and significantly lower total recurrence rate (P < 0.05). The "congestion" theory in Chapter VI On Pulse, Symptom Complex and Treatment of Arthralgia Due to Stagnation of Blood and Consumptive Diseases of Jingui Yaolue was the theoretical basis for postoperative effect observation of DHZCP in treating prostate cancer. Combining with the onset theory of congestion, personally, the author believed that cancer is caused by congestion disease formed by the extravasated blood in the human body, and with the passing of time, the intermingled deficiency, blood stasis, and toxicity lead to the qualitative change of endogenous cancer toxicity and develop into consumptive congestion disease, making it the core pathogenesis of cancer. And DHZCP had good preventive and treatment effect. Conclusion: DHZCP is an effective drug for improving postoperative complications of early-to-mid prostate cancer, reducing the biological recurrence rate and clinical recurrence rate, and improving mental status. The formula treats both deficiency and excess, combines tonification with purgation, and dispels exogenous pathogen without damaging body resistance, which is a profound formula based on TCM theory to treat "congestion," "congestion disease," and "consumptive congestion disease." Using this theory to guide clinical syndrome differentiation and treatment and modifying the dosage and usage can play an important role in TCM preventive treatment of cancers, early, middle, and late treatment, and clinical prevention of other chronic diseases.

A randomised controlled study: the effects of internal sphincterotomy of the anus on defecation disorders in patients with outlet obstructive and mixed constipation.

BACKGROUND: This study sought to investigate the effects of internal sphincterotomy of the anus in the treatment of defecation disorders in patients with outlet obstructive and mixed constipation. METHODS: This study included 250 patients, who met the Rome III criteria for functional defecation disorder-associated constipation and were admitted to the Proctology Department in the People's Hospital of Dazu District between July 2014 and June 2016. The patients were randomly divided into the traditional medical treatment group (n=125) and the surgical treatment group (n=125), and received traditional treatment and internal anal sphincterotomy, respectively. All patient clinical data were retrospectively analyzed. Indices relating to anorectal pressure, electromyographic indices of abdominal muscles, sleep quality, anxiety and depression, defecography and anal healing before and after treatment were measured, and the effects of the different treatment modalities on defecation disorders were analyzed. RESULTS: The total treatment effective rate was significantly higher in the surgical treatment group than in the traditional treatment group (P<0.05). The Constipation Scoring System scores at time points 1, 2 and 3 were significantly lower in the surgical treatment group than in the traditional treatment group (P<0.001). After treatment, the Hospital Anxiety and Depression Scale and Pittsburg Sleep Quality Index scores were significantly lower in the surgical treatment group than in the traditional treatment group (P<0.001). After treatment, the rectal resting pressure and 10SR were significantly lower in the surgical treatment group than in the traditional treatment group (P<0.001). After treatment, the negative conversion rate of the balloon expulsion test was significantly higher in the surgical treatment group than in the traditional treatment group (P<0.05), while the rectocele, perineum descending distance, and anorectal angle of the efforts phase were significantly lower in the surgical treatment group than in the traditional treatment group (P<0.001). CONCLUSIONS: Internal anal sphincterotomy can significantly relieve defecation disorders and clinical symptoms, improve sleep quality, eliminate psychological disorders, and promote patient recovery. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2100048818.