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Chem Commun (Camb)
; 57(26): 3235-3238, 2021 Apr 04.
Article
in English
| MEDLINE
| ID: mdl-33646236
ABSTRACT
We demonstrated that a synthetic ligand NA, which selectively binds to a 5'-CAG-3'/5'-CAG-3' triad, induced repeat contractions during DNA polymerase-mediated primer extension through the CAG repeat template. A thorough capillary electrophoresis and sequencing analysis revealed that the d(CAG)20 template gave shortened nascent strands mainly containing 3-6 CTG units in the presence of NA.